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- Hattori, Fumiyuki, et al. Show all 7 Authors
- Biomaterials 2018 v.161 pp. 270-278
- angiogenesis; binding capacity; collagen; endothelial cells; evolution; medicine; myocardial infarction; myocardium; therapeutics; vascular endothelial growth factors
- ... To enhance the therapeutic effect of growth factors, a powerful strategy is to direct their localization to damaged sites. To treat skin wounds and myocardial infarction, we selected vascular endothelial growth factor (VEGF) carrying binding affinity to collagen. A simple conjugation of a reported collagen-binding sequence and VEGF did not increase the collagen-binding affinity, indicating that th ...
- Hattori, Fumiyuki, et al. Show all 20 Authors
- Biochemical and biophysical research communications 2015 v.464 no.4 pp. 1000-1007
- cardiomyocytes; cell movement; early development; fluorescence; gene expression; gene expression regulation; image analysis; mice; mitosis; organogenesis; phase transition; regulator genes
- ... The precise assemblage of several types of cardiac precursors controls heart organogenesis. The cardiac precursors show dynamic movement during early development and then form the complicated heart structure. However, cardiomyocyte movements inside the newly organized mammalian heart remain unclear. We previously established the method of ex vivo time-lapse imaging of the murine heart to study car ...