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- Haumer, Alexander, et al. Show all 7 Authors
- Biomaterials 2019 v.192 pp. 118-127
- adipose tissue; bone formation; bone substitutes; bones; cartilage; endothelial cells; engineering; histology; pellets; rats; surgery
- ... Large and complex bone defects represent challenging clinical scenarios, typically requiring autologous vascularized bone transplants. In order to bypass the numerous associated limitations, here we aimed at ectopically prefabricating a bone graft surrogate with vascular pedicle.A hollow cylinder of devitalized cancellous bone was used to define the space of a large bone substitute. This space was ...
- Haumer, Alexander, et al. Show all 10 Authors
- Biomaterials 2018 v.171 pp. 219-229
- bone formation; bone marrow; cartilage; chondrocytes; chondrogenesis; encapsulation; engineering; humans; hydrogels; mesenchymal stromal cells; mice; models; nose; polyethylene glycol
- ... Despite the various reported approaches to generate osteochondral composites by combination of different cell types and materials, engineering of templates with the capacity to autonomously and orderly develop into cartilage-bone bi-layered structures remains an open challenge. Here, we hypothesized that the embedding of cells inducible to endochondral ossification (i.e. bone marrow derived mesenc ...