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1. Sensitivity of white sturgeon and rainbow trout to waterborne copper exposure: a comparative study of copper-induced disruption of sodium homeostasis

Author:
Hecker, Markus,   et al.   ; Shekh, Kamran; Alcaraz, Alper James; Niyogi, Som;     Show all 4 Authors
Source:
Aquatic toxicology 2019
ISSN:
0166-445X
Subject:
Acipenser transmontanus; Oncorhynchus mykiss; acute exposure; bioaccumulation; comparative study; copper; homeostasis; juveniles; lethal concentration 50; sodium; toxicity
Abstract:
... Recent studies have demonstrated that white sturgeon are more sensitive to acute exposure to Cu than rainbow trout (Oncorhynchus mykiss), especially during early life-stages. However, the physiological mechanisms underlying this difference in sensitivity to Cu is not known. In the present study, we first confirmed the higher sensitivity (lower 96 h LC50 values) of white sturgeon to Cu at three dif ...
DOI:
10.1016/j.aquatox.2019.105283

2. Species and life-stage specific differences in cadmium accumulation and cadmium induced oxidative stress, metallothionein and heat shock protein responses in white sturgeon and rainbow trout

Author:
Hecker, Markus,   et al.   ; Shekh, Kamran; Tang, Song; Kodzhahinchev, Vladimir; Niyogi, Som;     Show all 5 Authors
Source:
The Science of the total environment 2019 v.673 pp. 318-326
ISSN:
0048-9697
Subject:
Acipenser transmontanus; Oncorhynchus mykiss; antioxidant activity; biomarkers; cadmium; environmental assessment; genes; heat shock proteins; metallothionein; oxidative stress; risk assessment process; toxicity; toxicology; trout
Abstract:
... Understanding the mechanistic basis of differences in the sensitivity of fishes to metals is important for developing informed ecological risk assessment approaches for metals. Whole body metal accumulation, metallothionein induction, oxidative stress and associated antioxidant response, as well as heat shock proteins (mainly HSP70) are known to play important roles in determining the toxicity of ...
DOI:
10.1016/j.scitotenv.2019.04.083

3. Effects of selenium on benthic macroinvertebrates and fathead minnow (Pimephales promelas) in a boreal lake ecosystem

Author:
Hecker, Markus,   et al.   ; Graves, Stephanie D.; Liber, Karsten; Palace, Vince; Doig, Lorne E.; Janz, David M.;     Show all 6 Authors
Source:
Ecotoxicology and environmental safety 2019 v.182 pp. 109354
ISSN:
0147-6513
Subject:
Chironomidae; Gammaridae; Pimephales promelas; aquatic ecosystems; aquatic invertebrates; biomass; condition factor; exposure duration; females; fish; food availability; lakes; macroinvertebrates; risk; risk assessment; selenites; selenium; sexual maturity; sustainable development; toxicity; trophic levels; Ontario
Abstract:
... Selenium (Se) is a contaminant of concern in many aquatic ecosystems due to its narrow range between essentiality and toxicity in oviparous (yolk-bearing) vertebrates. The objective of the present study was to determine the effects of Se, experimentally added to in situ limnocorrals as selenite, on invertebrate communities and fathead minnow (Pimephales promelas) at environmentally realistic Se co ...
DOI:
10.1016/j.ecoenv.2019.06.037

4. In ovo exposure of fathead minnow (Pimephales promelas) to selenomethionine via maternal transfer and embryo microinjection: A comparative study

Author:
Hecker, Markus,   et al.   ; Lane, Taylor; Green, Derek; Bluhm, Kerstin; Raes, Katherine; Janz, David M.; Liber, Karsten;     Show all 7 Authors
Source:
Aquatic toxicology 2019
ISSN:
0166-445X
Subject:
Pimephales promelas; anthropogenic activities; aquatic ecosystems; bioaccumulation; breeding; comparative study; developmental stages; diet; dose response; early development; exposure pathways; fecundity; females; freshwater; indigenous species; males; minnows; models; oviposition; selenium; selenomethionine; teratogenicity; toxicology
Abstract:
... Selenium (Se) is an essential trace element of concern that is known to contaminate aquatic ecosystems as a consequence of releases from anthropogenic activities. Selenium is of particular toxicological concern for egg-laying vertebrates as they bioaccumulate Se through the diet and deposit excess Se to embryo-offspring via maternal transfer, a process which has been shown to result in significant ...
DOI:
10.1016/j.aquatox.2019.105299

5. Distribution of Experimentally Added Selenium in a Boreal Lake Ecosystem

Author:
Hecker, Markus,   et al.   ; Graves, Stephanie D.; Liber, Karsten; Palace, Vince; Doig, Lorne E.; Janz, David M.;     Show all 6 Authors
Source:
Environmental toxicology and chemistry 2019 v.38 no.9 pp. 1954-1966
ISSN:
0730-7268
Subject:
Chironomidae; Gammaridae; Pimephales promelas; United States Environmental Protection Agency; anthropogenic activities; aquatic environment; benthic organisms; ecosystems; eggs; exposure duration; females; lakes; macroinvertebrates; minnows; periphyton; sediments; selenites; selenium; sexual maturity; water; zooplankton; Ontario
Abstract:
... Human activities have increased the release of selenium (Se) to aquatic environments, but information about the trophic transfer dynamics of Se in Canadian boreal lake systems is limited. In the present study, Se was added as selenite to limnocorrals (2‐m‐diameter, 3000‐L in situ enclosures) in a boreal lake in northwestern Ontario to reach nominal concentrations of 1 and 10 µg Se/L in triplicate ...
DOI:
10.1002/etc.4508

6. Investigating the Role of Ionoregulatory Processes in the Species- and Life-Stage-Specific Differences in Sensitivity of Rainbow Trout and White Sturgeon to Cadmium

Author:
Hecker, Markus,   et al.   ; Shekh, Kamran; Tang, Song; Niyogi, Som;     Show all 4 Authors
Source:
Environmental science & technology 2018 v.52 no.21 pp. 12868-12876
ISSN:
1520-5851
Subject:
Acipenser transmontanus; Oncorhynchus mykiss; acute exposure; cadmium; calcium; homeostasis; juveniles; larvae; lethal concentration 50; sturgeon; trout
Abstract:
... There are huge variations in life-stage- and species-specific sensitivities among the fishes to the exposure with metals; however, the physiological mechanisms underlying these differences are not well understood to date. This study revealed significant life-stage-specific (larval, swim-up, and juvenile) and species-specific differences between two evolutionary distant species of fishes, rainbow t ...
DOI:
10.1021/acs.est.8b04828

7. A Cross-species Quantitative Adverse Outcome Pathway for Activation of the Aryl Hydrocarbon Receptor Leading to Early Life Stage Mortality in Birds and Fishes

Author:
Hecker, Markus,   et al.   ; Doering, Jon A.; Wiseman, Steve; Giesy, John P.;     Show all 4 Authors
Source:
Environmental science & technology 2018 v.52 no.13 pp. 7524-7533
ISSN:
1520-5851
Subject:
adverse effects; adverse outcome pathways; birds; developmental stages; dose response; environmental science; fish; mortality; regression analysis; transcriptional activation
Abstract:
... Dioxin-like compounds (DLCs) elicit adverse effects through activation of the aryl hydrocarbon receptor (AHR). Prior investigations demonstrated that sensitivity to activation of AHR1 in an in vitro AHR transactivation assay is predictive of early life stage mortality among birds. The present study investigated the link between sensitivity to activation of AHR1s and AHR2s and early life stage mort ...
DOI:
10.1021/acs.est.8b01438

8. Intrafollicular thyroid hormone staining in whole-mount zebrafish (Danio rerio) embryos for the detection of thyroid hormone synthesis disruption

Author:
Hecker, Markus,   et al.   ; Rehberger, Kristina; Baumann, Lisa; Braunbeck, Thomas;     Show all 4 Authors
Source:
Fish physiology and biochemistry 2018 v.44 no.3 pp. 997-1010
ISSN:
0920-1742
Subject:
Danio rerio; aorta; embryo (animal); endocrine-disrupting chemicals; fluorescence; larvae; propylthiouracil; protocols; staining; triiodothyronine; vertebrates
Abstract:
... Endocrine-disrupting chemicals are known to impact multiple hormonal axes of vertebrates, among which the thyroid system is crucial for multiple developmental and physiological processes. Thus, the present study focused on the semi-quantitative visualization of intrafollicular triiodothyronine (T3) and thyroxin (T4) in zebrafish embryos as a potential test system for the detection of disrupted thy ...
DOI:
10.1007/s10695-018-0488-y

9. Shape-dependent toxicity of alumina nanoparticles in rat astrocytes

Author:
Hecker, Markus,   et al.   ; Dong, Li; Tang, Song; Deng, Fuchang; Gong, Yufeng; Zhao, Kangfeng; Zhou, Jianjun; Liang, Donghai; Fang, Jianlong; Giesy, John P.; Bai, Xuetao; Zhang, Hongwei;     Show all 12 Authors
Source:
The Science of the total environment 2019 v.690 pp. 158-166
ISSN:
0048-9697
Subject:
aluminum oxide; amino acids; apoptosis; astrocytes; cerebral cortex; cytotoxicity; dose response; humans; inflammation; interleukin-1beta; interleukin-2; interleukin-6; lipids; metabolism; metabolome; metabolomics; nanoparticles; nanorods; neurotoxicity; physicochemical properties; purines; pyrimidines; rats; stress response; wildlife
Abstract:
... Nanosized alumina (Al2O3-NPs), a widely used nanoparticle in numerous commercial applications, is released into environment posing a threat to the health of wildlife and humans. Recent research has revealed essential roles of physicochemical properties of nanoparticles in determining their toxicity potencies. However, influence of shape on neurotoxicity induced by heterogeneous Al2O3-NPs remains u ...
DOI:
10.1016/j.scitotenv.2019.06.532

10. Acid mine drainage affects the diversity and metal resistance gene profile of sediment bacterial community along a river

Author:
Hecker, Markus,   et al.   ; Zhang, Xiaohui; Tang, Song; Wang, Mao; Sun, Weimin; Xie, Yuwei; Peng, Hui; Zhong, Aimin; Liu, Hongling; Zhang, Xiaowei; Yu, Hongxia; Giesy, John P.;     Show all 12 Authors
Source:
Chemosphere 2019 v.217 pp. 790-799
ISSN:
0045-6535
Subject:
Halomonas; Planococcaceae; acid mine drainage; arsenic; bacterial communities; byproducts; cadmium; community structure; copper; high-throughput nucleotide sequencing; lead; lotic systems; metal tolerance; mining; pH; pollution; resistance genes; rivers; salinity; sediments; sulfates
Abstract:
... Acid mine drainage (AMD) is one of the most hazardous byproducts of some types of mining. However, research on how AMD affects the bacterial community structure of downstream riverine ecosystems and the distribution of metal resistance genes (MRGs) along pollution gradient is limited. Comprehensive geochemical and high-throughput next-generation sequencing analyses can be integrated to characteriz ...
DOI:
10.1016/j.chemosphere.2018.10.210

11. Sensitive mass spectrometric assay for determination of 15-deoxy-Δ12,14-prostaglandin J2 and its application in human plasma samples of patients with diabetes

Author:
Hecker, Markus,   et al.   ; Morgenstern, Jakob; Fleming, Thomas; Kadiyska, Ivelina; Brings, Sebastian; Groener, JanBenedikt; Nawroth, Peter; Brune, Maik;     Show all 8 Authors
Source:
Analytical and bioanalytical chemistry 2018 v.410 no.2 pp. 521-528
ISSN:
1618-2642
Subject:
C-reactive protein; Food and Drug Administration; anti-inflammatory activity; biomarkers; cardiovascular diseases; diabetes; ethyl acetate; humans; inflammation; liquid-liquid extraction; mass spectrometry; methanol; neoplasms; patients; prostaglandins; urine
Abstract:
... The determination of individual prostaglandins (PG) in humans is mainly performed in urine samples. The quantification of PGs in human plasma could improve the understanding of particular PG species under various physiological and pathological conditions. 15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂ (15d-PGJ₂) is a dehydrated downstream product of PGD₂ and is of high interest due to its recently discovered an ...
DOI:
10.1007/s00216-017-0748-1
PubMed:
29143878
PubMed Central:
PMC5750338

12. Expression stability and selection of optimal reference genes for gene expression normalization in early life stage rainbow trout exposed to cadmium and copper

Author:
Hecker, Markus,   et al.   ; Shekh, Kamran; Tang, Song; Niyogi, Som;     Show all 4 Authors
Source:
Aquatic toxicology 2017 v.190 pp. 217-227
ISSN:
0166-445X
Subject:
ribosomal RNA; developmental stages; fish; hypoxanthine; DNA-directed RNA polymerase; DNA; cadmium; gene expression; ribosomal proteins; actin; geometry; tissues; NADP-glucose-6-phosphate dehydrogenase; copper; transcription (genetics); glyceraldehyde-3-phosphate dehydrogenase; acute exposure; algorithms; quantitative polymerase chain reaction; Oncorhynchus mykiss; reverse transcriptase polymerase chain reaction; gills; essential genes
Abstract:
... Gene expression analysis represents a powerful approach to characterize the specific mechanisms by which contaminants interact with organisms. One of the key considerations when conducting gene expression analyses using quantitative real-time reverse transcription-polymerase chain reaction (qPCR) is the selection of appropriate reference genes, which is often overlooked. Specifically, to reach mea ...
DOI:
10.1016/j.aquatox.2017.07.009

13. Effects of chronic exposure to dietary selenomethionine on the physiological stress response in juvenile white sturgeon (Acipenser transmontanus)

Author:
Hecker, Markus,   et al.   ; Patterson, Sarah; Zee, Jenna; Wiseman, Steve;     Show all 4 Authors
Source:
Aquatic toxicology 2017 v.186 pp. 77-86
ISSN:
0166-445X
Subject:
Acipenser transmontanus; acute exposure; adverse effects; bioaccumulation; blood glucose; blood plasma; chronic exposure; cortisol; cortisone; dietary exposure; energy; energy metabolism; exposure scenario; fish; genes; glucocorticoid receptors; glucose; glycogen; juveniles; lactic acid; lifestyle; liver; long term effects; longevity; muscles; quantitative polymerase chain reaction; selenium; selenomethionine; stress response; toxic substances; toxicity
Abstract:
... Selenium (Se) is an essential micronutrient, but at low concentrations can be toxic to aquatic organisms. Selenomethionine (SeMeth) is the primary dietary form of Se aquatic organisms are exposed to and is an environmental concern because it persists and bioaccumulates. White sturgeon (WS) might be particularly susceptible to bioaccumulative toxicants, such as SeMeth, due to their longevity and be ...
DOI:
10.1016/j.aquatox.2017.02.003

14. Factors associated with blooms of cyanobacteria in a large shallow lake, China

Author:
Hecker, Markus,   et al.   ; Li, Di; Wu, Naicheng; Tang, Song; Su, Guanyong; Li, Xuwen; Zhang, Yong; Wang, Guoxiang; Zhang, Junyi; Liu, Hongling; Giesy, John P.; Yu, Hongxia;     Show all 12 Authors
Source:
Environmental sciences Europe 2018 v.30 no.1 pp. 27
ISSN:
2190-4707
Subject:
Chlorophyta; Microcystis; arsenic; biochemical oxygen demand; community structure; drinking water; ecosystems; eutrophication; freshwater; lakes; metals; microcystin-LR; nitrogen content; pH; phosphorus; phytoplankton; primary productivity; public health; species diversity; spring; surface water; temperature; water quality; China
Abstract:
... BACKGROUND: Eutrophication of freshwater systems can result in blooms of phytoplankton, in many cases cyanobacteria. This can lead to shifts in structure and functions of phytoplankton communities adversely affecting the quality of drinking water sources, which in turn impairs public health. Relationships between structures of phytoplankton communities and concentrations of the toxicant, microcyst ...
DOI:
10.1186/s12302-018-0152-2
PubMed:
30148024
PubMed Central:
PMC6096964

15. Multiple biomarker responses in caged benthic gastropods Bellamya aeruginosa after in situ exposure to Taihu Lake in China

Author:
Hecker, Markus,   et al.   ; Li, Qian; Wang, Meng; Duan, Lei; Qiu, Yanling; Ma, Taowu; Chen, Ling; Breitholtz, Magnus; Bergman, Åke; Zhao, Jianfu; Wu, Lingling;     Show all 11 Authors
Source:
Environmental sciences Europe 2018 v.30 no.1 pp. 34
ISSN:
2190-4707
Subject:
Bellamya aeruginosa; DDE (pesticide); arsenic; bioactive properties; biomarkers; biotransformation; catalase; chemical analysis; copper; environmental monitoring; exposure duration; freshwater; freshwater ecosystems; hepatopancreas; lakes; lipid peroxidation; nickel; pollutants; pollution; polybrominated diphenyl ethers; polychlorinated biphenyls; reactive oxygen species; sediments; snails; superoxide dismutase; Canada; China
Abstract:
... BACKGROUND: Freshwater sediments have been recognized as a long-term sink and potential source for environmental pollutants released into the aquatic ecosystems. In this study, the sediment quality of Taihu Lake, which is susceptible to anthropogenic contamination, was assessed by a combination of chemical analytical and biological end points. Specifically, the snail Bellamya aeruginosa was caged ...
DOI:
10.1186/s12302-018-0164-y

16. Genomic instability in adult men involved in processing electronic waste in Northern China

Author:
Hecker, Markus,   et al.   ; Wang, Yan; Sun, Xiaohui; Fang, Lianying; Li, Keqiu; Yang, Ping; Du, Liqing; Ji, Kaihua; Wang, Jinhan; Liu, Qiang; Xu, Chang; Li, Guang; Giesy, John P.;     Show all 13 Authors
Source:
Environment international 2018 v.117 pp. 69-81
ISSN:
0160-4120
Subject:
DNA; DNA damage; adults; blood serum; burning; calcium; chromosome aberrations; comet assay; cytokinesis; electronic wastes; electronics; gene expression; genes; genomics; glutathione; lead; lymphocytes; magnesium; males; malondialdehyde; men; messenger RNA; oxidative stress; polychlorinated biphenyls; recycling; risk; spermatozoa; superoxide dismutase; trace elements; tumor suppressor proteins; waste disposal; China
Abstract:
... Managing and recycling electronic waste (e-waste), while useful and necessary, has resulted in significant contamination of several environments in China. The area around Tianjin, China has become one of the world's largest e-waste disposal centers, where electronics are processed by manually disassembly or burning, which can result in serious exposure of workers to a multitude of toxicants.The pr ...
DOI:
10.1016/j.envint.2018.04.027

17. Combining High-Throughput Sequencing of sedaDNA and Traditional Paleolimnological Techniques To Infer Historical Trends in Cyanobacterial Communities

Author:
Hecker, Markus,   et al.   ; Tse, Timothy J.; Doig, Lorne E.; Tang, Song; Zhang, Xiaohui; Sun, Weimin; Wiseman, Steve B.; Feng, Cindy Xin; Liu, Hongling; Giesy, John P.; Jones, Paul D.;     Show all 11 Authors
Source:
Environmental science & technology 2018 v.52 no.12 pp. 6842-6853
ISSN:
1520-5851
Subject:
Bacillariophyceae; DNA; anthropogenic activities; climate change; community structure; correlation; environmental quality; genes; high-throughput nucleotide sequencing; lakes; microbial communities; microcystins; monitoring; nutrients; paleoecology; pigments; ribosomal RNA; sediments; sterols; toxicity; Great Plains region
Abstract:
... Freshwaters worldwide are under increasing pressure from anthropogenic activities and changing climate. Unfortunately, many inland waters lack sufficient long-term monitoring to assess environmental trends. Analysis of sedimentary ancient DNA (sedaDNA) is emerging as a means to reconstruct the past occurrence of microbial communities of inland waters. The purpose of this study was to assess a comb ...
DOI:
10.1021/acs.est.7b06386

18. Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos

Author:
Hecker, Markus,   et al.   ; Hausen, Jonas; Otte, Jens C.; Legradi, Jessica; Yang, Lixin; Strähle, Uwe; Fenske, Martina; Tang, Song; Hammers-Wirtz, Monika; Hollert, Henner; Keiter, Steffen H.; Ottermanns, Richard;     Show all 12 Authors
Source:
Environmental science and pollution research international 2018 v.25 no.5 pp. 4023-4036
ISSN:
0944-1344
Subject:
Danio rerio; aroclors; chlorpyrifos; computer software; ecotoxicology; genes; methylmercury compounds; pollutants; pollution; sediments; transcriptome; transcriptomics
Abstract:
... In ecotoxicology, transcriptomics is an effective way to detect gene expression changes in response to environmental pollutants. Such changes can be used to identify contaminants or contaminant classes and can be applied as early warning signals for pollution. To do so, it is important to distinguish contaminant-specific transcriptomic changes from genetic alterations due to general stress. Here w ...
DOI:
10.1007/s11356-017-8977-6

19. In vitro tools for the toxicological evaluation of sediments and dredged materials: intra- and inter-laboratory comparisons of chemical and bioanalytical methods

Author:
Hecker, Markus,   et al.   ; Eichbaum, Kathrin; Brinkmann, Markus; Nuesser, Leonie; Gembé, Carolin; Ohlig, Marina; Buchinger, Sebastian; Reifferscheid, Georg; Giesy, John P.; Hollert, Henner;     Show all 10 Authors
Source:
Environmental science and pollution research international 2018 v.25 no.5 pp. 4037-4050
ISSN:
0944-1344
Subject:
batteries; bioassays; cell lines; detection limit; dredged materials; guidelines; mass spectrometry; risk assessors; rivers; screening; toxicity; toxicity testing
Abstract:
... The implementation of in vitro bioassays for the screening of dioxin-like compounds (DLCs) into management guidelines of dredged material is of increasing interest to regulators and risk assessors. This study reports on an intra- and inter-laboratory comparison study between four independent laboratories. A bioassay battery consisting of RTL-W1 (7-ethoxy-resorufin-O-deethylase; EROD), H4IIE (micro ...
DOI:
10.1007/s11356-017-0094-z

20. Adverse health effects and histological changes in white sturgeon (Acipenser transmontanus) exposed to dietary selenomethionine

Author:
Hecker, Markus,   et al.   ; Zee, Jenna; Patterson, Sarah; Gagnon, Danielle;     Show all 4 Authors
Source:
Environmental toxicology and chemistry 2016 v.35 no.7 pp. 1741-1750
ISSN:
0730-7268
Subject:
Acipenser transmontanus; adverse effects; aquatic environment; diet study techniques; dose response; edema; energy; environmental fate; food choices; hepatosomatic index; histology; juveniles; life history; liver; muscles; selenium; selenomethionine; sturgeon; toxicity; wildlife
Abstract:
... It has been shown that selenium (Se) released to the aquatic environment can have devastating effects on local wildlife. White sturgeon (Acipenser transmontanus) have a life history particularly susceptible to contaminants, and their protection is of interest as they are culturally and economically important, and many populations are classified as endangered. During the present 72‐d dietary study, ...
DOI:
10.1002/etc.3320