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- Henderson, Steven, et al. Show all 28 Authors
- Cell 2019 v.177 no.3 pp. 622-638.e22
- DNA repair; accelerated aging; amino acids; evolution; longevity; mice; mutants; phenotype; solar radiation
- ... DNA repair has been hypothesized to be a longevity determinant, but the evidence for it is based largely on accelerated aging phenotypes of DNA repair mutants. Here, using a panel of 18 rodent species with diverse lifespans, we show that more robust DNA double-strand break (DSB) repair, but not nucleotide excision repair (NER), coevolves with longevity. Evolution of NER, unlike DSB, is shaped prim ...
- Henderson, Steven T., et al. Show all 4 Authors
- Plant reproduction 2013 v.26 no.2 pp. 113-123
- Hieracium; Pilosella; apomixis; backcrossing; embryogenesis; endosperm; fruits; genes; genetic techniques and protocols; genotype; loci; meiosis; mutants; ovules; penetrance; pollination; progeny; quantitative traits; seeds
- ... In apomictic Hieracium subgenus Pilosella species, embryo sacs develop in ovules without meiosis. Embryo and endosperm formation then occur without fertilization, producing seeds with a maternal genotype encased in a fruit (achene). Genetic analyses in H. praealtum indicate a dominant locus (LOA) controls meiotic avoidance, and another dominant locus (LOP) controls both fertilization-independent e ...