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- Henning, R.H., et al. Show all 6 Authors
- Biochimica et biophysica acta 2016 v.1860 no.11 pp. 2521-2528
- apoptosis; brain; cold shock proteins; cooling; glutamic acid; head; hypothermia; ischemia; mitochondria; neurons; neuroprotective effect; oxidative stress; stroke; surgery; translation (genetics); unfolded protein response
- ... Targeted temperature management (TTM) is the induced cooling of the entire body or specific organs to help prevent ischemia and reperfusion (I/R) injury, as may occur during major surgery, cardiac resuscitation, traumatic brain injury and stroke. Ischemia and reperfusion induce neuronal damage by mitochondrial dysfunction and oxidative injury, ER stress, neuronal excitotoxicity, and a neuroinflamm ...
- Henning, R.H., et al. Show all 8 Authors
- Veterinary immunology and immunopathology 2010 v.136 no.3-4 pp. 319-323
- hibernation; immune system; adaptation; immunosuppression (physiological); squirrels; Spermophilus; blood cells; phenotype; lymphocyte count; thrombocytes; granulocytes; monocytes; leukopenia; thrombocytopenia; temporal variation; thermoregulation
- ... Hibernation is a unique natural model to study large and specific modulation in numbers of leukocytes and thrombocytes, with potential relevance for medical application. Hibernating animals cycle through cold (torpor) and warm (arousal) phases. Previous research demonstrated clearance of leukocytes and thrombocytes from the circulation during torpor, but did not provide information regarding the t ...