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- Heo, Seok-Jin, et al. Show all 8 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.32 pp. E2977
- DNA; DNA methylation; antibodies; breast neoplasms; cytidine deaminase; cytosine; epigenetics; epithelial cells; gene expression; genes; genomic islands; mammary glands; metastasis; models; morphogenesis; neoplasm cells; somatic cells; transcription factors
- ... Activation-induced cytidine deaminase (AID), which functions in antibody diversification, is also expressed in a variety of germ and somatic cells. Evidence that AID promotes DNA demethylation in epigenetic reprogramming phenomena, and that it is induced by inflammatory signals, led us to investigate its role in the epithelial–mesenchymal transition (EMT), a critical process in normal morphogenesi ...
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