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1. Abnormal growth induced by expression of HBsAg in the secretion pathway of S. cerevisiae pep4 mutants

Author:
Chen, D.C.; Chuang, L.T.; Chen, W.; Kuo, T.
Source:
Current genetics 1995 v.27 no.3 pp. 201-206
ISSN:
0172-8083
Subject:
Hepatitis B virus,   etc   ; Saccharomyces cerevisiae; cytotoxicity; structural genes; gene transfer; genetic transformation; protein secretion; mutants; proteinases; ammonium sulfate; nutrient availability; recombinant DNA; viral antigens;     Show all 13 Subjects
Abstract:
... The toxicity of HBsAg in the secretion pathway of pep4 strains can be progressively reduced in modified SD media containing lower concentrations of ammonium sulphate. A procedure, combining a reduction of ammonium sulphate concentration in SD media with the disruption of the PEP4 gene of the host strain, was developed to enrich transformants which are not inhibited by HBsAg expressed in the secret ...
DOI:
10.1007/BF00326149
PubMed:
7736602

2. A broadly reactive monoclonal antibody detects multiple genotypes of hepatitis B virus X protein

Author:
Wei, Lili; Shen, Zhongliang; Zhao, Xue; Wu, Yanxin; Liu, Wei; Zhang, Junqi; Xie, Youhua; Liu, Jing
Source:
Archives of virology 2014 v.159 no.10 pp. 2731-2735
ISSN:
0304-8608
Subject:
Hepatitis B virus,   etc   ; cultured cells; fluorescent antibody technique; gene overexpression; genome; genotype; hepatocytes; immunoblotting; monoclonal antibodies; plasmids; proteins;     Show all 11 Subjects
Abstract:
... A highly specific and broadly reactive monoclonal antibody against hepatitis B virus X (HBx) protein was developed that detected, in both immunoblotting and immunofluorescence, HBx proteins of seven of the eight currently known genotypes of HBV, which were overexpressed in cultured cells. Evaluation of HBx expression levels in cultured hepatocytes using this monoclonal antibody showed that cells t ...
DOI:
10.1007/s00705-014-2111-6
PubMed:
24838854

3. A capacitive biosensor based on an interdigitated electrode with nanoislands

Author:
Jung, Ha-Wook; Chang, Young Wook; Lee, Ga-yeon; Cho, Sungbo; Kang, Min-Jung; Pyun, Jae-Chul
Source:
Analytica chimica acta 2014 v.844 pp. 27-34
ISSN:
0003-2670
Subject:
Hepatitis B virus,   etc   ; adsorption; analytical chemistry; antigen-antibody reactions; biosensors; electrodes; hepatitis B antigens; peroxidase; surface antigens;     Show all 9 Subjects
Abstract:
... A capacitive biosensor based on an interdigitated electrode (IDE) with nanoislands was developed for label-free detection of antigen-antibody interactions. To enable sensitive capacitive detection of protein adsorption, the nanoislands were fabricated between finger electrodes of the IDE. The effect of the nanoislands on the sensitive capacitive measurement was estimated using horseradish peroxida ...
DOI:
10.1016/j.aca.2014.07.006

4. A case of hepatitis B reactivation due to the hepatitis B virus escape mutant in a patient undergoing chemotherapy

Author:
Wu, Chunchen; Shi, Hui; Wang, Yun; Lu, Mengji; Xu, Yang; Chen, Xinwen
Source:
Virologica Sinica 2012 v.27 no.6 pp. 368-371
ISSN:
1674-0769
Subject:
Hepatitis B virus,   etc   ; liver cirrhosis; bilirubin; drug therapy; liver; antigens; humans; enzymes; morbidity; DNA; mutation; disease control; liver failure; relative risk; genotype; chronic hepatitis B; mutants; patients; mortality;     Show all 19 Subjects
Abstract:
... A 62-year-old man had chronic hepatitis B virus (HBV) infection and was diagnosed with liver cirrhosis. At the time of diagnosis the patient’s virologic markers were positive for hepatitis B surface antigen (HBsAg), antibody to hepatitis B e antigen (anti-HBe) and antibody to hepatitis B core antigen (anti-HBc), while antibody to hepatitis B surface antigen (anti-HBs) and HBV DNA were negative. La ...
DOI:
10.1007/s12250-012-3284-3
PubMed:
23180290

5. A chemical lipid modification of recombinant preS antigen to study the mechanism of HBV attachment to the host cell

Author:
Chen, Bin; Lian, Min; Xu, Shili; Luo, Ming; Zheng, Xiaofeng
Source:
Journal of biotechnology 2008 v.137 no.1-4 pp. 8-13
ISSN:
0168-1656
Subject:
Hepatitis B virus,   etc   ; acylation; binding capacity; biotechnology; cell membranes; flow cytometry; hepatocytes; human cell lines; hydrophobic bonding; pathogenicity; receptors; surface antigens; viruses;     Show all 13 Subjects
Abstract:
... Surface antigen preS of Hepatitis B virus plays fundamental roles in mediating receptor recognition and virus internalization. Myristoylation at N-terminal Gly² residue of preS is essential for viral attachment and infectivity. A number of myristoylated proteins have been shown to undergo a conformational change (myristoyl switch) that alters their affinity to cell membrane. However, there is litt ...
DOI:
10.1016/j.jbiotec.2008.06.010

6. Acidic polysaccharides isolated from marine algae inhibit the early step of viral infection

Author:
Ueno, Mikinori; Nogawa, Masato; Siddiqui, Rokeya; Watashi, Koichi; Wakita, Takaji; Kato, Nobuyuki; Ikeda, Masanori; Okimura, Takasi; Isaka, Shogo; Oda, Tatsuya; Ariumi, Yasuo
Source:
International journal of biological macromolecules 2019 v.124 pp. 282-290
ISSN:
0141-8130
Subject:
Hepatitis B virus,   etc   ; HIV infections; Hepatitis C virus; Human immunodeficiency virus 1; Primate T-lymphotropic virus 1; Vesiculovirus; algae; alginates; dose response; human cell lines; uronic acids;     Show all 11 Subjects
Abstract:
... We examined the effects of various acidic polysaccharides isolated from marine algae on the infection and replication of human immunodeficiency virus type-1 (HIV-1), hepatitis B virus (HBV), hepatitis C virus (HCV), and human T-cell leukemia virus type-1 (HTLV-1). It was found that sulfated fucan polysaccharides, ascophyllan, and two fucoidans derived from different sources significantly inhibited ...
DOI:
10.1016/j.ijbiomac.2018.11.152

7. A collaborative study to establish the 3rd WHO International Standard for hepatitis B virus for nucleic acid amplification techniques

Author:
Fryer, Jacqueline F.; Heath, Alan B.; Wilkinson, Dianna E.; Minor, Philip D.
Source:
Biologicals 2017 v.46 pp. 57-63
ISSN:
1045-1056
Subject:
Hepatitis B virus,   etc   ; World Health Organization; blood; diagnostic techniques; freeze drying; gene amplification; monitoring; screening; thermal degradation;     Show all 9 Subjects
Abstract:
... Nucleic acid amplification techniques (NAT) are routinely used for clinical diagnostics and monitoring hepatitis B virus (HBV) infections, and are implemented on a voluntary basis for blood screening. A collaborative study was performed to evaluate a replacement WHO International Standard for HBV for the standardization of NAT. Two lyophilised HBV candidates were evaluated by 16 laboratories world ...
DOI:
10.1016/j.biologicals.2016.12.003

8. A comparative analysis of the efficiency of bird and mammalian antibodies in HBsAg sandwich assay

Author:
Pechelyulko, A. A.; Tarakanova, Yu. N.; Dmitriev, D. A.; Massino, Yu. S.; Segal, O. L.; Lavrov, V. F.; Dmitriev, A. D.
Source:
Applied biochemistry and microbiology 2017 v.53 no.1 pp. 114-122
ISSN:
0003-6838
Subject:
Hepatitis B virus,   etc   ; antigen-antibody complex; chemical elements; chickens; detection limit; enzyme immunoassays; goats; hepatitis B antigens; immunoglobulin Y; mice; monoclonal antibodies; polyclonal antibodies; surface antigens;     Show all 13 Subjects
Abstract:
... The antigen-binding capacities of chicken and goat polyclonal antibodies and mouse monoclonal antibodies specific for the hepatitis B virus surface antigen were compared via enzyme immunoassay. It was shown that the use of both adsorbed and detecting chicken antibodies reduces significantly the analytical sensitivity of the sandwich method for the detection of this antigen. It was assumed that the ...
DOI:
10.1134/S0003683817010136

9. A Concise History of Mycotoxin Research

Author:
Pitt, John I.; Miller, J. David
Source:
Journal of agricultural and food chemistry 2017 v.65 no.33 pp. 7021-7033
ISSN:
1520-5118
Subject:
Hepatitis B virus,   etc   ; Aspergillus flavus; Balkan endemic nephropathy; Claviceps purpurea; Fusarium; Penicillium; T-2 toxin; aflatoxins; beriberi; climate change; diet; ergotism; food availability; fumonisins; fungi; grain crops; horses; humans; liver neoplasms; monitoring; niches; nuts; ochratoxin A; rice; rye; saprophytes; toxicity; toxigenic strains; Brazil; Japan; Russia;     Show all 31 Subjects
Abstract:
... Toxigenic fungi and mycotoxins entered human food supplies about the time when mankind first began to cultivate crops and to store them from one season to the next, perhaps 10,000 years ago. The storage of cereals probably initiated the transition by mankind from hunter-gatherer to cultivator, at the same time providing a vast new ecological niche for fungi pathogenic on grain crops or saprophytic ...
DOI:
10.1021/acs.jafc.6b04494

10. A conserved RNA structural element within the hepatitis B virus post-transcriptional regulatory element enhance nuclear export of intronless transcripts and repress the splicing mechanism

Author:
Visootsat, Akasit; Payungporn, Sunchai; T-Thienprasert, Nattanan P.
Source:
Molecular biology reports 2015 v.42 no.12 pp. 1603-1614
ISSN:
0301-4851
Subject:
Hepatitis B virus,   etc   ; antiviral agents; bioinformatics; gene expression regulation; hepatoma; liver cirrhosis; luciferase; messenger RNA; neoplasm cells; physiological transport; plasmids; regulatory sequences;     Show all 12 Subjects
Abstract:
... Hepatitis B virus (HBV) infection is a primary cause of hepatocellular carcinoma and liver cirrhosis worldwide. To develop novel antiviral drugs, a better understanding of HBV gene expression regulation is vital. One important aspect is to understand how HBV hijacks the cellular machinery to export unspliced RNA from the nucleus. The HBV post-transcriptional regulatory element (HBV PRE) has been p ...
DOI:
10.1007/s11033-015-3928-0

11. Acquisition rate of antibody to hepatitis B surface antigen among medical and dental students in Japan after three-dose hepatitis B vaccination

Author:
Nagashima, Shintaro; Yamamoto, Chikako; Ko, Ko; Chuon, Channarena; Sugiyama, Aya; Ohisa, Masayuki; Akita, Tomoyuki; Katayama, Keiko; Yoshihara, Masaharu; Tanaka, Junko
Source:
Vaccine 2019 v.37 no.1 pp. 145-151
ISSN:
0264-410X
Subject:
Hepatitis B virus,   etc   ; antibodies; health care workers; hepatitis B; hepatitis B antigens; males; risk; students; vaccination; vaccines; Japan;     Show all 11 Subjects
Abstract:
... Health care workers (HCWs) are at high risk of contracting blood-borne infections including hepatitis B virus (HBV) infection. In Japan, all HCWs are required to receive HB vaccination before beginning work. This study aimed to investigate the dynamics of the HB surface antibody (anti-HBs) titer after a three-dose HB vaccination in HCWs and to determine effective scheduling of HB vaccination for n ...
DOI:
10.1016/j.vaccine.2018.11.019

12. Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4ʹ-modified nucleoside RT inhibitors

Author:
Yasutake, Yoshiaki; Hattori, Shin-ichiro; Tamura, Noriko; Matsuda, Kouki; Kohgo, Satoru; Maeda, Kenji; Mitsuya, Hiroaki
Source:
Biochemical and biophysical research communications 2019 v.509 no.4 pp. 943-948
ISSN:
0006-291X
Subject:
Hepatitis B virus,   etc   ; Human immunodeficiency virus 1; RNA-directed DNA polymerase; active sites; amino acid substitution; amino acids; antiviral agents; drug design; guanosine; mutants;     Show all 10 Subjects
Abstract:
... Nucleoside analogue reverse transcriptase (RT) inhibitors (NRTIs) are major antiviral agents against hepatitis B virus (HBV) and human immunodeficiency virus type-1 (HIV-1). However, the notorious insoluble property of HBV RT has prevented atomic-resolution structural studies and rational anti-HBV drug design. Here, we created HIV-1 RT mutants containing HBV-mimicking sextuple or septuple amino ac ...
DOI:
10.1016/j.bbrc.2019.01.026

13. A -819 C/T polymorphism in the interleukin-10 promoter is associated with persistent HBV infection, but -1082 A/G and -592A/C polymorphisms are not: a meta-analysis

Author:
Ren, Hong; Zhang, Ting-Ting; Hu, Wen-Long
Source:
Archives of virology 2015 v.160 no.3 pp. 747-756
ISSN:
0304-8608
Subject:
Hepatitis B virus,   etc   ; Asians; alleles; databases; disease course; haplotypes; interleukin-10; meta-analysis; promoter regions; risk; single nucleotide polymorphism;     Show all 11 Subjects
Abstract:
... Single-nucleotide polymorphisms (SNPs) in the interleukin-10 (IL10) gene promoter have been associated with persistent hepatitis B virus (HBV) infection. In particular, the -1082A/G, -819 C/T and -592 A/C polymorphisms have most often been implicated. We performed a meta-analysis of available data to determine the relative importance of these SNPs in persistent HBV infection. We searched available ...
DOI:
10.1007/s00705-014-2317-7

14. A description of the hepatitis B virus genomic background in a high-prevalence area in China

Author:
Chen, Xiaoming; Gao, Jie; Ji, Zhaohua; Zhang, Weilu; Zhang, Lei; Xu, Rui; Zhang, Jingxia; Li, Fei; Li, Shi; Hu, Shijie; Shang, Lei; Shao, ZhongJun; Yan, Yongping
Source:
Virology journal 2014 v.11 no.1 pp. 2440
ISSN:
1743-422X
Subject:
Hepatitis B virus,   etc   ; antiviral agents; cities; drug resistance; genotype; hepatitis B; hepatitis B antigens; mutation; nucleotide sequences; people; screening; strains; surface antigens; vaccination; vaccines; China;     Show all 16 Subjects
Abstract:
... BACKGROUND: Hepatitis B (HB) is an important disease worldwide. Almost 350 million people are positive for Hepatitis B virus surface antigen (HBsAg), and one-third of them live in China. According to a nation-wide serosurvey in China in 2006, the prevalence of HBsAg was higher in Northwest China than in other areas. However, the epidemic HBV strains in this area are poorly studied. RESULTS: In thi ...
DOI:
10.1186/1743-422X-11-101
PubMed:
24884702
PubMed Central:
PMC4074864

15. A differential ELISA based on recombinant immunodominant epitopes of the gE gene of SHV-1 in a baculovirus–insect cell system to discriminate between pigs infected naturally with pseudorabies and vaccinated pigs

Author:
Serena, María Soledad; Metz, Germán Ernesto; Corva, Santiago Gerardo; Mórtola, Eduardo Carlos; Echeverría, María Gabriela
Source:
Journal of virological methods 2011 v.171 no.2 pp. 388-393
ISSN:
0166-0934
Subject:
Hepatitis B virus,   etc   ; Suid alphaherpesvirus 1; antigen detection; Human immunodeficiency virus 1; Bluetongue virus; viral nonstructural proteins; antibodies; Bovine leukemia virus; Orthomyxoviridae; Aujeszky disease; polymerization; recombinant proteins; enzyme-linked immunosorbent assay; immunodominant epitopes; ultracentrifugation; genes; viruses; Foot-and-mouth disease virus; swine;     Show all 19 Subjects
Abstract:
... In the present study, the fragment corresponding to the immunodominant epitopes of the gE gene (gEpi) from the CL15 Argentinean strain of pseudorabies virus was expressed successfully in a baculovirus–insect cell system that contained the M6 gene of Bluetongue virus, which encodes the NS1 nonstructural protein. This protein has the ability to polymerize into highly immunogenic tubules inside infec ...
DOI:
10.1016/j.jviromet.2010.12.005

16. Adolescent booster with hepatitis B virus vaccines decreases HBV infection in high-risk adults

Author:
Wang, Yuting; Chen, Taoyang; Lu, Ling-ling; Wang, Minjie; Wang, Dongmei; Yao, Hongyu; Fan, Chunsun; Qi, Jun; Zhang, Yawei; Qu, Chunfeng
Source:
Vaccine 2017 v.35 no.7 pp. 1064-1070
ISSN:
0264-410X
Subject:
Hepatitis B virus,   etc   ; adolescents; adulthood; adults; blood sampling; blood serum; childhood; children; hepatitis B; hepatitis B antigens; mothers; neutralizing antibodies; odds ratio; risk factors; surface antigens; vaccination; vaccines;     Show all 17 Subjects
Abstract:
... Neutralizing antibodies (anti-HBs) after immunization with hepatitis B virus (HBV) vaccines against HBV surface antigen (HBsAg) wane after 10–15years. We analyzed the effect of an adolescent booster given to vaccination-protected children born to mothers with different HBsAg-carrying status against HBV infection in their mature adulthood.A total of 9793 individuals, who were HBsAg-negative at chil ...
DOI:
10.1016/j.vaccine.2016.12.062

17. Advanced generation of paeonol-phenylsufonyl derivatives as potential anti-HBV agents

Author:
Huang, Y. P.; Shih, H. P.; Liang, Y. C.; Lin, H. H.; Lin, M. C.; Chen, C. W.; Huang, T. J.; Kuo, Y. C.; Han, C. C.; Hsu, M. H.
Source:
RSC advances 2016 v.6 no.49 pp. 43556-43562
ISSN:
2046-2069
Subject:
Hepatitis B virus,   etc   ; antiviral agents; antiviral properties; chronic hepatitis B; drugs; inhibitory concentration 50; lamivudine; organochlorine compounds;     Show all 8 Subjects
Abstract:
... Hepatitis B virus (HBV) infection causes serious liver diseases, and the development of effective drugs for chronic hepatitis B treatment remains an important step towards the eradication of HBV worldwide. Recently, our group designed paeonol-phenylsulfonyl derivatives and found that the compound 2-acetyl-5-methoxyphenyl 4-methoxybenzenesulfonate (6f) had the most potent antiviral effect against H ...
DOI:
10.1039/c6ra06119b

18. Advances with using CRISPR/Cas-mediated gene editing to treat infections with hepatitis B virus and hepatitis C virus

Author:
Moyo, Buhle; Bloom, Kristie; Scott, Tristan; Ely, Abdullah; Arbuthnot, Patrick
Source:
Virus research 2018 v.244 pp. 311-320
ISSN:
0168-1702
Subject:
Hepatitis B virus,   etc   ; Francisella tularensis subsp. novicida; Hepatitis C virus; RNA; antiviral agents; circular DNA; cultured cells; drugs; gene transfer; genes; hepatitis B; hepatitis C; hepatoma; mice; viruses;     Show all 15 Subjects
Abstract:
... Chronic infections with hepatitis B and hepatitis C viruses (HBV and HCV) account for the majority of cases of cirrhosis and hepatocellular carcinoma. Current therapies for the infections have limitations and improved efficacy is necessary to prevent complications in carriers of the viruses. In the case of HBV persistence, the replication intermediate comprising covalently closed circular DNA (ccc ...
DOI:
10.1016/j.virusres.2017.01.003

19. Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods

Author:
Rushing, Blake R.; Selim, Mustafa I.
Source:
Food and chemical toxicology 2019 v.124 pp. 81-100
ISSN:
0278-6915
Subject:
Hepatitis B virus,   etc   ; Aspergillus; DNA; aflatoxin B1; chemical control; corn; epoxidation reactions; food availability; food supply chain; fungi; hepatoma; humans; immunomodulation; malnutrition; metabolism; occupational exposure; synergism; toxicity;     Show all 18 Subjects
Abstract:
... Aflatoxins are a class of carcinogenic mycotoxins produced by Aspergillus fungi and are known to contaminate a large portion of the world's food supply. Aflatoxin B1 (AFB1) is the most potent of these compounds and has been well-characterized to lead to the development of hepatocellular carcinoma (HCC) in humans and animals. This review focuses on the metabolism of AFB1, including epoxidation and ...
DOI:
10.1016/j.fct.2018.11.047

20. Aflatoxin Exposure in Developing Countries: The Critical Interface of Agriculture and Health

Author:
Wild, Christopher Paul
ISSN:
0379-5721
Subject:
Hepatitis B virus,   etc   ; aflatoxins; animal diseases; carcinogens; children; developing countries; farmed animal species; growth retardation; human population; humans; immunity; infectious diseases; liver; public health; staple foods; Western Africa;     Show all 16 Subjects
Abstract:
... Aflatoxins are common contaminants of staple foods in sub-Saharan Africa. These toxins are human liver carcinogens, especially in combination with chronic infection with hepatitis B virus. However, in an agricultural setting, the effects on growth, immune status, and susceptibility to infectious disease in farm animals are also well recognized. These latter effects have been far less explored in h ...
DOI:
10.1177/15648265070282S217