Author: "Hope, Thomas J." - PubAg Search Results

Author:: Hope, Thomas J., et al. ; Schneider, Jeffrey R.; Carias, Ann M.; Bastian, Arangaserry R.; Cianci, Gianguido C.; Kiser, Patrick F.; Veazey, Ronald S.; Show all 7 Authors
Source:: Journal of Immunological Methods 2017
ISSN:: 0022-1759
Subject:: Macaca mulatta; animal models; antibodies; biopsy; enzyme-linked immunosorbent assay; fluorescent dyes; humans; image analysis; immunoglobulin G; intravenous injection; mucosa; mucus; surface plasmon resonance; tissue distribution; vagina
Abstract:: ... The use of therapeutic antibodies, delivered by intravenous (IV) instillation, is a rapidly expanding area of biomedical treatment for a variety of conditions. However, little is known about how the antibodies are anatomically distributed following infusion and the underlying mechanism mediating therapeutic antibody distribution to specific anatomical sites remains to be elucidated. Current effort ...
DOI:: 10.1016/j.jim.2017.07.009
PubMed:: 28780040
PubMed Central:: PMC5603196
: http://dx.doi.org/10.1016/j.jim.2017.07.009

Author:: Hope, Thomas J., et al. ; Hulme, Amy E.; Perez, Omar; Show all 3 Authors
Source:: Proceedings of the National Academy of Sciences of the United States of America 2011 v.108 no.24 pp. 9975-9980
ISSN:: 0027-8424
Subject:: Aotus (Cebidae); HIV infections; Human immunodeficiency virus 1; RNA-directed DNA polymerase; capsid; fluorescence; kidneys; reverse transcription; virus replication
Abstract:: ... During the early stages of HIV-1 replication the conical capsid composed of p24CA protein dissociates from the rest of the cytoplasmic viral complex by a process called uncoating. Although proper uncoating is known to be required for HIV-1 infection, many questions remain about the timing and factors involved in the process. Here we have used two complementary assays to study the process of uncoat ...
DOI:: 10.1073/pnas.1014522108
PubMed:: 21628558
PubMed Central:: PMC3116424
: http://dx.doi.org/10.1073/pnas.1014522108

Author:: Hope, Thomas J., et al. ; Yu, Zhiheng; Dobro, Megan J.; Woodward, Cora L.; Levandovsky, Artem; Danielson, Cindy M.; Sandrin, Virginie; Shi, Jiong; Aiken, Christopher; Zandi, Roya; Jensen, Grant J.; Show all 11 Authors
Source:: Journal of Molecular Biology 2013 v.425 pp. 112-123
ISSN:: 0022-2836
Subject:: Equine infectious anemia virus; Human immunodeficiency virus 1; RNA; capsid; coat proteins; genome; green fluorescent protein; image analysis; models
Abstract:: ... The RNA genome of retroviruses is encased within a protein capsid. To gather insight into the assembly and function of this capsid, we used electron cryotomography to image human immunodeficiency virus (HIV) and equine infectious anemia virus (EIAV) particles. While the majority of viral cores appeared closed, a variety of unclosed structures including rolled sheets, extra flaps, and cores with ho ...
DOI:: 10.1016/j.jmb.2012.10.006
PubMed:: 23079241
PubMed Central:: PMC3597093
: http://dx.doi.org/10.1016/j.jmb.2012.10.006

Author:: Hope, Thomas J., et al. ; Mahalingam, Alamelu; Jay, Julie I.; Langheinrich, Kristofer; Shukair, Shetha; McRaven, Mike D.; Rohan, Lisa C.; Herold, Betsy C.; Kiser, Patrick F.; Show all 9 Authors
Source:: Biomaterials 2011 v.32 no.33 pp. 8343-8355
ISSN:: 0142-9612
Subject:: Human immunodeficiency virus; active ingredients; animal models; crosslinking; diffusivity; drugs; explants; humans; modulus of elasticity; mucins; mucus; pH; polymers; semen; toxicity; virion
Abstract:: ... In conjunction with the routine role of delivering the active ingredient, carefully designed drug delivery vehicles can also provide ancillary functions that augment the overall efficacy of the system. Inspired by the ability of the cervicovaginal mucus to impede the movement of HIV virions at acidic pH, we have engineered a pH-responsive synthetic polymer that shows improved barrier properties ov ...
DOI:: 10.1016/j.biomaterials.2011.05.001
PubMed:: 21875751
PubMed Central:: PMC3183097
: http://dx.doi.org/10.1016/j.biomaterials.2011.05.001

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