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- Hou, Dongxia, et al. Show all 16 Authors
- Biomaterials 2019 v.210 pp. 83-93
- Hepatitis B virus; RNA interference; adverse effects; biogenesis; gene expression; genes; hepatitis B antigens; lettuce; liver; mice; microRNA; nucleotide sequences; public health; small interfering RNA; surface antigens; therapeutics; transgenic animals
- ... Chronic infection with hepatitis B virus (HBV) is a major public health problem. Recently, RNA interfering-based strategy has shown great potential to eradicate HBV infection. In current study, we report the experimental observation of plant-derived artificial microRNAs (amiRNAs) acting as therapeutics in HBsAg−/+ transgenic mice. Two pieces of small silencing RNA sequences, siR471 and siR519, aga ...
- Hou, Dongxia, et al. Show all 17 Authors
- The Journal of nutritional biochemistry 2018 v.57 pp. 197-205
- blood serum; blood vessels; cardiovascular diseases; cell communication; endothelial cells; gene expression; humans; in vitro studies; liver; low density lipoprotein; mice; microRNA; monocytes; patients; rice
- ... MicroRNAs have become the spotlight of the biological community for more than a decade, but we are only now beginning to understand their functions. The detection of stably expressed endogenous microRNAs in human blood suggests that these circulating miRNAs can mediate intercellular communication. Our previous study reported the surprising finding that exogenous rice MIR168a could regulate liver l ...