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- Huun, Johanna, et al. Show all 5 Authors
- BBA - General Subjects 2013 v.1830 pp. 2790-2797
- anthracyclines; apoptosis; beta-galactosidase; binding capacity; breast neoplasms; fluorescent antibody technique; genes; humans; metastasis; mitomycin; mutants; mutation; patients; precipitin tests; quantitative polymerase chain reaction
- ... Approximately 4300 different TP53 mutations have been reported in human cancers. TP53 mutations, in particular those affecting the L2/L3 domains, are associated with resistance to anthracycline or mitomycin treatment in breast cancer patients. While many mutations have been characterised functionally, novel TP53 mutations are continuously reported. Here, we characterise 10 p53 protein variants enc ...