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1. Analysis of chicken intestinal natural killer cells, a major IEL subset during embryonic and early life

Author:
Jansen, Christine A.,   et al.   ; Meijerink, Nathalie; van Haarlem, Daphne A.; Velkers, Francisca C.; Stegeman, Arjan J.; Rutten, Victor P.M.G.;     Show all 6 Authors
Source:
Developmental and comparative immunology 2021 v.114 pp. 103857
ISSN:
0145-305X
Subject:
T-lymphocytes; anti-infective agents; bone marrow; immunology; intestines; spleen
Abstract:
... Restrictions on antimicrobials demand alternative strategies to improve broiler health, such as supplying feed additives which stimulate innate immune cells like natural killer (NK) cells. The main objective of this study was to characterize intestinal NK cells in broiler chickens during embryonic and early life and compare these to NK cells in spleen, blood and bone marrow. Also T-cell subsets we ...
DOI:
10.1016/j.dci.2020.103857

2. The contribution of the immune response to enhanced colibacillosis upon preceding viral respiratory infection in broiler chicken in a dual infection model

Author:
Jansen, Christine A.,   et al.   ; Weerts, Erik A.W.S.; Matthijs, Mieke G.R.; Bonhof, Josette; van Haarlem, Daphne A.; Dwars, R. Marius; Gröne, Andrea; Verheije, M. Hélène;     Show all 8 Authors
Source:
Veterinary immunology and immunopathology 2021 v.238 pp. 110276
ISSN:
0165-2427
Subject:
Avian metapneumovirus; Avian orthoavulavirus 1; Escherichia coli; Infectious bronchitis virus; air; bacterial antigens; body weight; broiler chickens; euthanasia; gene expression; immune response; immunohistochemistry; immunopathology; interleukin-10; interleukin-17; interleukin-6; lungs; macrophages; models; monocytes; pneumonia; tracheitis
Abstract:
... Colibacillosis in chickens caused by avian pathogenic Escherichia coli (APEC) is known to be aggravated by preceding infections with infectious bronchitis virus (IBV), Newcastle disease virus (NDV) and avian metapneumovirus (aMPV). The mechanism behind these virus-induced predispositions for secondary bacterial infections is poorly understood. Here we set out to investigate the immunopathogenesis ...
DOI:
10.1016/j.vetimm.2021.110276

3. Innate immune training and metabolic reprogramming in primary monocytes of broiler and laying hens

Author:
Jansen, Christine A.,   et al.   ; Verwoolde, Michel B.; van den Biggelaar, Robin H.G.A.; de Vries Reilingh, Ger; Arts, Joop A.J.; van Baal, Jürgen; Lammers, Aart;     Show all 7 Authors
Source:
Developmental and comparative immunology 2021 v.114 pp. 103811
ISSN:
0145-305X
Subject:
disease resistance; inflammation; innate immunity; interleukin-4; lipopolysaccharides; monocytes
Abstract:
... Recently, we have reported trained innate immunity in laying chicken monocytes. In the present study, we further investigated trained innate immunity of monocytes in layers and broilers. Monocytes of both breeds isolated from blood were trained in vitro with β-glucan, rec-chicken IL-4 or a combination of both, and restimulated with lipopolysaccharide (LPS), after which inflammation and metabolism- ...
DOI:
10.1016/j.dci.2020.103811

4. Early and later life environmental enrichment affect specific antibody responses and blood leukocyte subpopulations in pigs

Author:
Jansen, Christine A.,   et al.   ; Luo, Lu; Bolhuis, J. Elizabeth; Arts, Joop A.J.; Kemp, Bas; Parmentier, Hendrik K.;     Show all 6 Authors
Source:
Physiology & behavior 2020 v.217 pp. 112799
ISSN:
0031-9384
Subject:
T-lymphocytes; antibodies; blood sampling; cytotoxicity; environmental enrichment; granulocytes; immunization; immunoglobulin G; immunoglobulin M; life history; limpets; monocytes; personality; swine
Abstract:
... This study addressed the impact of early and later life environmental enrichment, and their combination, on specific antibody responses and peripheral blood leukocyte subpopulations in pigs. Pigs were kept in either barren (B1) or enriched (E1) housing from birth, and half of the pigs switched to barren or enriched housing on day 47, resulting in four treatment combinations: B1B2, B1E2, E1B2, E1E2 ...
DOI:
10.1016/j.physbeh.2020.112799

5. Training of Primary Chicken Monocytes Results in Enhanced Pro-Inflammatory Responses

Author:
Jansen, Christine A.,   et al.   ; Verwoolde, Michel B.; van den Biggelaar, Robin H. G. A.; van Baal, Jürgen; Lammers, Aart;     Show all 5 Authors
Source:
Veterinary sciences 2020 v.7 no.3
ISSN:
2306-7381
Subject:
White Leghorn; chickens; flow cytometry; innate immunity; interleukin-4; lipopolysaccharides; macrophages; major histocompatibility complex; mammals; monocytes; nitric oxide; vaccination
Abstract:
... Beta-glucan-stimulated mammalian myeloid cells, such as macrophages, show an increased responsiveness to secondary stimulation in a nonspecific manner. This phenomenon is known as trained innate immunity and is important to prevent reinfections. Trained innate immunity seems to be an evolutionary conserved phenomenon among plants, invertebrates and mammalian species. Our study aimed to explore the ...
DOI:
10.3390/vetsci7030115

6. Chicken lines divergently selected on feather pecking differ in immune characteristics

Author:
Jansen, Christine A.,   et al.   ; van der Eijk, Jerine A.J.; Verwoolde, Michel B.; de Vries Reilingh, Ger; Rodenburg, T. Bas; Lammers, Aart;     Show all 6 Authors
Source:
Physiology & behavior 2019 v.212 pp. 112680
ISSN:
0031-9384
Subject:
adaptive immunity; animal welfare; antibodies; feather pecking; feathers; hens; immunoglobulin G; immunoglobulin M; monocytes; nitric oxide; pecking
Abstract:
... It is crucial to identify whether relations between immune characteristics and damaging behaviors in production animals exist, as these behaviors reduce animal welfare and productivity. Feather pecking (FP) is a damaging behavior in chickens, which involves hens pecking and pulling at feathers of conspecifics. To further identify relationships between the immune system and FP we characterized high ...
DOI:
10.1016/j.physbeh.2019.112680

7. Impact of Yeast-Derived β-Glucans on the Porcine Gut Microbiota and Immune System in Early Life

Author:
Jansen, Christine A.,   et al.   ; de Vries, Hugo; Geervliet, Mirelle; Rutten, Victor P. M. G.; van Hees, Hubèrt; Groothuis, Natalie; Wells, Jerry M.; Savelkoul, Huub F. J.; Tijhaar, Edwin; Smidt, Hauke;     Show all 10 Authors
Source:
Microorganisms 2020 v.8 no.10
ISSN:
2076-2607
Subject:
Salmonella Typhimurium; blood; diet; digesta; feces; immune response; immune system; intestinal microorganisms; microbial colonization; piglets; sampling; vaccination; weaning
Abstract:
... Piglets are susceptible to infections in early life and around weaning due to rapid environmental and dietary changes. A compelling target to improve pig health in early life is diet, as it constitutes a pivotal determinant of gut microbial colonization and maturation of the host’s immune system. In the present study, we investigated how supplementation of yeast-derived β-glucans affects the gut m ...
DOI:
10.3390/microorganisms8101573

8. Chicken NK cell receptors

Author:
Jansen, Christine A.,   et al.   ; Straub, Christian; Neulen, Marie-Luise; Sperling, Beatrice; Windau, Katharina; Zechmann, Maria; Viertlboeck, Birgit C.; Göbel, Thomas W.;     Show all 8 Authors
Source:
Developmental and comparative immunology 2013 v.41 no.3 pp. 324-333
ISSN:
0145-305X
Subject:
antigens; chickens; genome; mammals; natural killer cells; receptors; spleen
Abstract:
... Natural killer cells are innate immune cells that destroy virally infected or transformed cells. They recognize these altered cells by a plethora of diverse receptors and thereby differ from other lymphocytes that use clonally distributed antigen receptors. To date, several receptor families that play a role in either activating or inhibiting NK cells have been identified in mammals. In the chicke ...
DOI:
10.1016/j.dci.2013.03.013

9. Chicken dendritic cells are susceptible to highly pathogenic avian influenza viruses which induce strong cytokine responses

Author:
Jansen, Christine A.,   et al.   ; Vervelde, Lonneke; Reemers, Sylvia S.; van Haarlem, Daphne A.; Post, Jacob; Claassen, Erwin; Rebel, Johanna M.J.;     Show all 7 Authors
Source:
Developmental and comparative immunology 2013 v.39 no.3 pp. 198-206
ISSN:
0145-305X
Subject:
Orthomyxoviridae; Toll-like receptor 1; avian influenza; chickens; dendritic cells; gene expression; immune response; interferon-alpha; interferon-gamma; interleukin-8; mammals; messenger RNA; mortality; pathogenicity
Abstract:
... Infection with highly pathogenic avian influenza (HPAI) in birds and mammals is associated with severe pathology and increased mortality. We hypothesize that in contrast to low pathogenicity avian influenza (LPAI) infection, HPAI infection of chicken dendritic cells (DC) induces a cytokine deregulation which may contribute to their highly pathogenic nature. Infection of DC with LPAI H7N1 and H5N2 ...
DOI:
10.1016/j.dci.2012.10.011