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- Jiang, Qingguang, et al. Show all 8 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.25 pp. 10601-10606
- Alzheimer disease; amyloid; brain; cholesterol; cholesterol metabolism; gene expression; genes; inflammation; liver; mice; neurodegenerative diseases; neuroglia; pathogenesis; phagocytosis; receptors; transgenic animals
- ... Alzheimer's disease (AD) is an age-dependent neurodegenerative disease that causes progressive cognitive impairment. The initiation and progression of AD has been linked to cholesterol metabolism and inflammation, processes that can be modulated by liver x receptors (LXRs). We show here that endogenous LXR signaling impacts the development of AD-related pathology. Genetic loss of either Lxrα or Lx ...
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