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- Author:
- Jonathan Arzt, et al. ; James J. Zhu; Jessica A. Canter; Luis L. Rodriguez; Show all 4 Authors
- Source:
- Veterinary immunology and immunopathology 2020 v.220 pp. 109990
- ISSN:
- 0165-2427
- Subject:
- DNA microarrays; Primates; amino acid sequences; amino acids; binding sites; bioinformatics; cattle; chemotaxis; chickens; epithelium; gene expression regulation; innate immunity; interleukin-8; lungs; mice; multigene family; nasopharynx; neutrophils; nose; palate; phylogeny; promoter regions; sequence alignment; swine; tongue; transcription (genetics); transcription factors; transcriptomics
- Abstract:
- ... In our previous transcriptomic studies using DNA microarray analysis, a probe designed from an unknown expressed sequence tag (EST) showed significant differential gene expression in the pharyngeal epithelia. The objectives of this study are to annotate the gene sequence and compare the gene transcription levels among different bovine tissues based on our published microarray data. The gene transc ...
- DOI:
- 10.1016/j.vetimm.2019.109990
- https://doi.org/10.1016/j.vetimm.2019.109990
- Author:
- Jonathan Arzt, et al. ; Carolina Stenfeldt; Miranda Bertram R.; George Smoliga R.; Ethan Hartwig J.; Amy Delgado H.; Show all 6 Authors
- Source:
- Frontiers in veterinary science 2020 v.7 no. pp. -
- ISSN:
- 2297-1769
- Subject:
- Foot-and-mouth disease virus; airborne transmission; cold storage; epithelium; foot-and-mouth disease; infectious disease incubation period; pathogen survival; pathogenesis; pathogenicity; pig carcasses; sentinel animals; swine; virus transmission
- Abstract:
- ... Data-driven modeling of incursions of high-consequence, transboundary pathogens of animals is a critical component of veterinary preparedness. However, simplifying assumptions and excessive use of proxy measures to compensate for gaps in available data may compromise modeled outcomes. The current investigation was prospectively designed to address two major gaps in current knowledge of foot-and-mo ...
- Handle:
- 10113/6987824
- DOI:
- 10.3389/fvets.2020.00334
- https://doi.org/10.3389/fvets.2020.00334
- Author:
- Jonathan Arzt, et al. ; Michael Eschbaumer; Veronika Dill; Jolene C. Carlson; Carolina Stenfeldt; Peter W. Krug; John M. Hardham; Jacob E. Stegner; Luis L. Rodriguez; Elizabeth Rieder; Show all 10 Authors
- Source:
- Pathogens 2020 v.9 no.2 pp. -
- ISSN:
- 2076-0817
- Subject:
- Foot-and-mouth disease virus; amino acid substitution; biocontainment; blood serum; cattle; foot-and-mouth disease; hooves; necropsy; nose; pathogens; proteinases; risk; swine; vaccines; viral proteins; viral shedding; virulence; viruses
- Abstract:
- ... Inactivated whole-virus vaccines are widely used for the control of foot-and-mouth disease (FMD). Their production requires the growth of large quantities of virulent FMD virus in biocontainment facilities, which is expensive and carries the risk of an inadvertent release of virus. Attenuated recombinant viruses lacking the leader protease coding region have been proposed as a safer alternative fo ...
- DOI:
- 10.3390/pathogens9020129
- https://doi.org/10.3390/pathogens9020129
- Author:
- Jonathan Arzt, et al. ; Jack Rhyan; Matthew McCollum; Thomas Gidlewski; Moshe Shalev; Gordon Ward; Brenda Donahue; Carolina Stenfeldt; Fawzi Mohamed; Pauline Nol; Ming Deng; Samia Metwally; Mo Salman; Show all 13 Authors
- Source:
- Journal of wildlife diseases 2020 v.56 no.1 pp. 93-104
- ISSN:
- 0090-3558
- Subject:
- Foot-and-mouth disease virus; Odocoileus hemionus; animal diseases; antibodies; deer; disease transmission; foot-and-mouth disease; laboratory experimentation; mortality; myocarditis; pathogenesis; polymerase chain reaction; proteins; serotypes; signs and symptoms (animals and humans); steers; tongue; viral shedding; viruses; wildlife; California
- Abstract:
- ... The only known outbreak of foot-and-mouth disease (FMD) in wildlife in the US occurred in mule deer (Odocoileus hemionus) in California in 1924–25. There is little recorded information on the pathogenesis and epidemiology of the disease in deer in that outbreak. In this experimental study, we compared the susceptibility of mule deer to FMD virus (FMDV) serotype O to that of cattle (Bos taurus). We ...
- Handle:
- 10113/6805078
- DOI:
- 10.7589/2019-03-059
- https://doi.org/10.7589/2019-03-059
5. Characterization of transboundary foot‐and‐mouth disease viruses in Nigeria and Cameroon during 2016
- Author:
- Jonathan Arzt, et al. ; David Odion Ehizibolo; Ian H. Fish; Barbara Brito; Miranda R. Bertram; Abdullahi Ardo; Hussaini G. Ularamu; David D. Lazarus; Yiltawe S. Wungak; Chika I. Nwosuh; George R. Smoliga; Ethan J. Hartwig; Steven James Pauszek; Simon Dickmu; Souley Abdoulkadiri; Show all 15 Authors
- Source:
- Transboundary and emerging diseases 2020 v.67 no.3 pp. 1257-1270
- ISSN:
- 1865-1674
- Subject:
- animals; foot-and-mouth disease; genotype; monitoring; pastoralism; phylogeny; risk; serotypes; trade; viruses; Cameroon; Nigeria; Northern Africa
- Abstract:
- ... Continuous surveillance for foot‐and‐mouth disease (FMD) in endemic settings such as West Africa is imperative to support improved local and regional control plans, with the long‐term goal of regional eradication. This paper describes the genetic characterization of FMD viruses (FMDV) obtained from outbreaks in Nigeria (n = 45) and Cameroon (n = 15) during 2016 and from archival samples (n = 3) re ...
- DOI:
- 10.1111/tbed.13461
- https://doi.org/10.1111/tbed.13461
- Author:
- Jonathan Arzt, et al. ; George Omondi; Moh A. Alkhamis; Vincent Obanda; Francis Gakuya; Abraham Sangula; Steven Pauszek; Andres Perez; Stephen Ngulu; Richard van Aardt; Kim VanderWaal; Show all 11 Authors
- Source:
- Molecular ecology 2019 v.28 no.11 pp. 2903-2916
- ISSN:
- 0962-1083
- Subject:
- Bayesian theory; Foot-and-mouth disease virus; Syncerus caffer; anthropogenic activities; buffaloes; cattle; epidemiology; genes; hosts; models; monitoring; phylogeography; viruses; wildlife; Kenya; Tanzania; Uganda; Zimbabwe
- Abstract:
- ... Understanding the dynamics of foot‐and‐mouth disease virus (FMDV), an endemic and economically constraining disease, is critical in designing control programmes in Africa. This study investigates the evolutionary epidemiology of SAT1 and SAT2 FMDV in Eastern Africa, as well as between cattle and wild African buffalo. Bayesian phylodynamic models were used to analyse SAT1 and SAT2 VP1 gene segments ...
- DOI:
- 10.1111/mec.15125
- https://doi.org/10.1111/mec.15125
- Author:
- Jonathan Arzt, et al. ; Lauro Velazquez-Salinas; Steven J. Pauszek; Jose Barrera; Benjamin A. Clark; Manuel V. Borca; Antonio Verdugo-Rodriguez; Carolina Stenfeldt; Luis L. Rodriguez; Show all 9 Authors
- Source:
- Journal of virological methods 2019 v.265 pp. 113-116
- ISSN:
- 0166-0934
- Subject:
- DNA-directed RNA polymerase; Vesicular stomatitis New Jersey virus; cell lines; clones; complementary DNA; genes; growth models; nucleoproteins; phosphoproteins; plasmid vectors; signs and symptoms (animals and humans); site-specific recombination; swine; swine diseases; vesicular stomatitis; virulence; viruses
- Abstract:
- ... This study reports the use of a site-specific recombination cloning technique for rapid development of a full-length cDNA clone that can produce infectious vesicular stomatitis New Jersey virus (VSNJV). The full-length genome of the epidemic VSNJV NJ0612NME6 strain was amplified in four overlapping cDNA fragments which were linked together and cloned into a vector plasmid by site-specific recombin ...
- DOI:
- 10.1016/j.jviromet.2019.01.003
- https://doi.org/10.1016/j.jviromet.2019.01.003
- Author:
- Jonathan Arzt, et al. ; Juan M. Pacheco; Carolina Stenfeldt; Luis L. Rodriguez; Show all 4 Authors
- Source:
- Virology journal 2017 v.14 no.1 pp. 89
- ISSN:
- 1743-422X
- Subject:
- Foot-and-mouth disease virus; aerosols; antigens; cattle; clones; epithelial cells; foot-and-mouth disease; genomics; hosts; lungs; mucosa; mutants; mutation; nasopharynx; pathogenesis; proteinases; transposons; vaccines; viral load; viremia; virulence; viruses
- Abstract:
- ... BACKGROUND: Understanding the mechanisms of attenuation and virulence of foot-and-mouth disease virus (FMDV) in the natural host species is critical for development of next-generation countermeasures such as live-attenuated vaccines. Functional genomics analyses of FMDV have identified few virulence factors of which the leader proteinase (Lₚᵣₒ) is the most thoroughly investigated. Previous work fr ...
- DOI:
- 10.1186/s12985-017-0758-9
- PubMed:
- 28464897
- PubMed Central:
- PMC5414290
- CHORUS:
- 10.1186/s12985-017-0758-9
- https://doi.org/10.1186/s12985-017-0758-9
- Author:
- Jonathan Arzt, et al. ; Carolina Stenfeldt; George Smoliga; Michael LaRocco; Joseph Gutkoska; Paul Lawrence; Show all 6 Authors
- Source:
- Virology journal 2017 v.14 no.1 pp. 71
- ISSN:
- 1743-422X
- Subject:
- Foot-and-mouth disease virus; acute course; apoptosis; blood serum; cattle; cell proliferation; chronic diseases; foot-and-mouth disease; humans; immune response; lipid metabolism; microRNA; polymerase chain reaction; serotypes; viruses
- Abstract:
- ... BACKGROUND: Changes in the levels of circulating microRNAs (miRNAs) in the serum of humans and animals have been detected as a result of infection with a variety of viruses. However, to date, such a miRNA profiling study has not been conducted for foot-and-mouth disease virus (FMDV) infection. METHODS: The relative abundance of 169 miRNAs was measured in bovine serum collected at three different p ...
- DOI:
- 10.1186/s12985-017-0743-3
- PubMed:
- 28388926
- PubMed Central:
- PMC5384155
- https://doi.org/10.1186/s12985-017-0743-3
- Author:
- Jonathan Arzt, et al. ; Karla I. Moreno-Torres; Barbara P. Brito; . Branan; Luis L. Rodriguez; Amy H. Delgado; Carolina Stenfeldt; Show all 7 Authors
- Source:
- Frontiers in veterinary science 2018 v.5 no.167 pp. -
- ISSN:
- 2297-1769
- Subject:
- Foot-and-mouth disease virus; blood serum; detection limit; direct contact; estimated exposure dose; foot-and-mouth disease; infectious disease incubation period; microbial detection; oral administration; oropharynx; swine; swine diseases; viral load; viral shedding; virus transmission
- Abstract:
- ... The quantitative relationship between the exposure dose of foot-and-mouth disease virus (FMDV) and subsequent infection dynamics has been demonstrated through controlled inoculation studies in various species. However, similar quantitation of viral doses has not been achieved during contact exposure experiments due to the intrinsic difficulty of measuring the virus quantities exchanged between ani ...
- Handle:
- 10113/6471414
- DOI:
- 10.3389/fvets.2018.00167
- PubMed:
- 30079340
- PubMed Central:
- PMC6062637
- CHORUS:
- 10.3389/fvets.2018.00167
- https://doi.org/10.3389/fvets.2018.00167
- Author:
- Jonathan Arzt, et al. ; Rajeev Ranjan; Jitendra K. Biswal; Saravanan Subramaniam; Bana B. Dash; Karam P. Singh; Luis L. Rodriguez; Bramhadev Pattnaik; Show all 8 Authors
- Source:
- Tropical animal health and production 2018 v.50 no.5 pp. 1167-1170
- ISSN:
- 0049-4747
- Subject:
- Foot-and-mouth disease virus; RNA; adults; calves; cows; dairy herds; foot-and-mouth disease; pathogenesis; signs and symptoms (animals and humans); viral nonstructural proteins; viruses; India
- Abstract:
- ... Foot-and-mouth disease (FMD) is a highly contagious and economically important, transboundary viral disease of cloven-hoofed animals. It is known that an asymptomatic, persistent FMD virus (FMDV) infection may occur subsequent to acute or subclinical FMDV infection in adult ruminants. However, virus persistence in young calves has not been studied. In the current investigation, FMDV infection para ...
- DOI:
- 10.1007/s11250-018-1518-6
- https://doi.org/10.1007/s11250-018-1518-6
- Author:
- Jonathan Arzt, et al. ; Tatjana Sitt; Mary Kenney; José Barrera; Mital Pandya; Korin Eckstrom; Megan Warner; Juan M. Pacheco; Michael LaRocco; Javier Palarea-Albaladejo; David Brake; Elizabeth Rieder; John W. Barlow; William T. Golde; Show all 14 Authors
- Source:
- Vaccine 2019 v.37 no.42 pp. 6221-6231
- ISSN:
- 0264-410X
- Subject:
- Foot-and-mouth disease virus; Holstein; Mastadenovirus; blood serum; capsid; cattle diseases; coat proteins; field experimentation; foot-and-mouth disease; half life; humoral immunity; neutralizing antibodies; serotypes; steers; subunit vaccines; vaccination; viral shedding
- Abstract:
- ... Foot-and-mouth disease (FMD) is a highly contagious viral infection of cloven hooved animals that continues to cause economic disruption in both endemic countries or when introduced into a formally FMD free country. Vaccines that protect against clinical disease and virus shedding are critical to control FMD. The replication deficient human adenovirus serotype 5 (Ad5) vaccine vector expressing emp ...
- DOI:
- 10.1016/j.vaccine.2019.08.017
- CHORUS:
- 10.1016/j.vaccine.2019.08.017
- https://doi.org/10.1016/j.vaccine.2019.08.017
- Author:
- Jonathan Arzt, et al. ; Umer Farooq; Zaheer Ahmed; Khalid Naeem; Miranda Bertram; Barbara Brito; Carolina Stenfeldt; Steven J. Pauszek; Michael LaRocco; Luis Rodriguez; Show all 10 Authors
- Source:
- Transboundary and emerging diseases 2018 v.65 no.6 pp. 1836-1850
- ISSN:
- 1865-1674
- Subject:
- Bubalus bubalis; Foot-and-mouth disease virus; RNA; antibodies; buffaloes; carrier state; emerging diseases; endemic diseases; farms; foot-and-mouth disease; hosts; longitudinal studies; phylogeny; seroprevalence; serotypes; Pakistan
- Abstract:
- ... The convalescent subclinical carrier state of foot‐and‐mouth disease virus (FMDV) infection has been thoroughly investigated; contrastingly, the subclinical form of new infections of vaccinated and naïve hosts is recognized, but poorly understood. To investigate the natural dynamics of subclinical FMDV infections, a prospective, 12‐month, longitudinal study was conducted in vaccinated Asian buffal ...
- DOI:
- 10.1111/tbed.12963
- CHORUS:
- 10.1111/tbed.12963
- Chorus Open Access:
- 10.1111/tbed.12963
- https://doi.org/10.1111/tbed.12963
- Author:
- Jonathan Arzt, et al. ; Fayna Diaz-San Segundo; Gisselle N. Medina; Carolina Stenfeldt; Teresa de los Santos; Show all 5 Authors
- Source:
- Veterinary microbiology 2017 v.206 pp. 102-112
- ISSN:
- 0378-1135
- Subject:
- animal health; cattle; developed countries; food security; foot-and-mouth disease; genetic variation; goats; host range; morbidity; sheep; subsistence farming; swine; vaccines
- Abstract:
- ... Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals. The disease affects many areas of the world, often causing extensive epizootics in livestock, mostly farmed cattle and swine, although sheep, goats and many wild species are also susceptible. In countries where food and farm animals are essential for subsistence agriculture, outbreaks of FMD seriously impact food ...
- DOI:
- 10.1016/j.vetmic.2016.12.018
- CHORUS:
- 10.1016/j.vetmic.2016.12.018
- https://doi.org/10.1016/j.vetmic.2016.12.018
- Author:
- Jonathan Arzt, et al. ; Steven I. Rekant; Mark A. Lyons; Juan M. Pacheco; Luis L. Rodriguez; Show all 5 Authors
- Source:
- American journal of veterinary research 2016 v.77 no.1 pp. 98-107
- ISSN:
- 0002-9645
- Subject:
- animal welfare; body temperature; disease detection; feed conversion; horses; host range; hosts; monitoring; pregnancy; stress response; surface temperature; thermography; veterinary medicine
- Abstract:
- ... Abnormal body temperature is a major indicator of disease; infrared thermography (IRT) can assess changes in body surface temperature quickly and remotely. This technology can be applied to a myriad of diseases of various etiologies across a wide range of host species in veterinary medicine. It is used to monitor the physiologic status of individual animals, such as measuring feed efficiency or di ...
- DOI:
- 10.2460/ajvr.77.1.98
- https://doi.org/10.2460/ajvr.77.1.98
- Author:
- Jonathan Arzt, et al. ; Nestor Montiel; George Smoliga; Show all 3 Authors
- Source:
- Vaccine 2012 v.30 no.9 pp. 1690-1701
- ISSN:
- 0264-410X
- Subject:
- luciferase; Human mastadenovirus C; cell lines; dendritic cells; DNA; gene expression; viruses; lymph nodes; infection; tropisms; messenger RNA; humans; serotypes; cattle; immune response; antigen presentation; transgenes; injection site; vaccines; Foot-and-mouth disease virus; genetic vectors
- Abstract:
- ... Recombinant replication-defective human adenovirus type 5 (Ad5) vaccines containing capsid-coding regions from foot-and-mouth disease virus (FMDV) have been demonstrated to induce effective immune responses and provide homologous protective immunity against FMDV in cattle. However, basic mechanisms of Ad5-FMDV vaccine function including virus tropism, transgene expression, and antigen presentation ...
- Handle:
- 10113/54146
- DOI:
- 10.1016/j.vaccine.2011.12.082
- https://doi.org/10.1016/j.vaccine.2011.12.082
17. Effect of vaccination on cattle subclinically infected with foot-and-mouth disease virus in Cameroon
- Author:
- Jonathan Arzt, et al. ; Miranda R. Bertram; Amy Delgado; Steven J. Pauszek; George R. Smoliga; Barbara Brito; Carolina Stenfeldt; Ethan J. Hartwig; Simon Dickmu Jumbo; Mamoudou Abdoulmoumini; Amba Abona Oliva Marie; Robert Salhine; Luis L. Rodriguez; Rebecca Garabed; Show all 14 Authors
- Source:
- Preventive veterinary medicine 2018 v.155 pp. 1-10
- ISSN:
- 0167-5877
- Subject:
- Foot-and-mouth disease virus; RNA; blood serum; cattle; endemic diseases; financial economics; foot-and-mouth disease; herds; inactivated vaccines; livestock diseases; sequence analysis; seroconversion; seroprevalence; serotypes; signs and symptoms (animals and humans); vaccination; viral nonstructural proteins; Cameroon
- Abstract:
- ... Foot-and-mouth disease (FMD) is one of the most contagious and economically important livestock diseases worldwide. Four serotypes of FMD virus (FMDV; O, A, SAT1, SAT2) circulate in Cameroon, and a trivalent inactivated vaccine against the three most common serotypes (O, A, SAT2) was recently introduced in 2014. The objective of this study was to characterize vaccine performance in cattle under na ...
- Handle:
- 10113/6329971
- DOI:
- 10.1016/j.prevetmed.2018.04.003
- https://doi.org/10.1016/j.prevetmed.2018.04.003
- Author:
- Jonathan Arzt, et al. ; Carolina Stenfeldt; Barbara P. Brito; Karla I. Moreno-Torres; Amy H. Delgado; Luis L. Rodriguez; Juan M. Pacheco; Matt A. Branan; Show all 8 Authors
- Source:
- Frontiers in Veterinary Science 2016 v.3 no. pp. 105-118
- ISSN:
- 2297-1769
- Subject:
- Foot-and-mouth disease virus; disease outbreaks; disease transmission; foot-and-mouth disease; infectious disease incubation period; lesions (animal); models; pathogens; prediction; swine; viral shedding; viremia; viruses
- Abstract:
- ... Understanding the quantitative characteristics of a pathogen’s capability to transmit during distinct phases of infection is important to enable accurate predictions of the spread and impact of a disease outbreak. In the current investigation, the potential for transmission of foot-and-mouth disease virus (FMDV) during the incubation (preclinical) period of infection was investigated in seven grou ...
- Handle:
- 10113/5852184
- DOI:
- 10.3389/fvets.2016.00105
- PubMed:
- 27917386
- PubMed Central:
- PMC5116750
- CHORUS:
- 10.3389/fvets.2016.00105
- https://doi.org/10.3389/fvets.2016.00105
- Author:
- Jonathan Arzt, et al. ; Carolina Stenfeldt; Juan M. Pacheco; Nagendrakumar B. Singanallur; Helena C. de Carvalho Ferreira; Wilna Vosloo; Luis L. Rodriguez; Show all 7 Authors
- Source:
- Veterinary microbiology 2015 v.178 no.1-2 pp. 50-60
- ISSN:
- 0378-1135
- Subject:
- Foot-and-mouth disease virus; aerosols; direct contact; foot-and-mouth disease; pathogenesis; pharynx; serotypes; sheep; viral shedding; virulence; virus replication; viruses; South East Asia
- Abstract:
- ... Within-host infection dynamics of a recent field isolate of foot-and-mouth disease virus (FMDV), serotype O, topotype South East Asia, lineage Myamar’98 were evaluated in sheep using four different systems for virus exposure. Two novel, simulated natural, inoculation systems consisting of intra-nasopharyngeal (INP) deposition and aerosol inoculation were evaluated in comparison with two convention ...
- Handle:
- 10113/61578
- DOI:
- 10.1016/j.vetmic.2015.04.004
- CHORUS:
- 10.1016/j.vetmic.2015.04.004
- Chorus Open Access:
- 10.1016/j.vetmic.2015.04.004
- https://doi.org/10.1016/j.vetmic.2015.04.004
- Author:
- Jonathan Arzt, et al. ; Michael Eschbaumer; Carolina Stenfeldt; Steven I. Rekant; Juan M. Pacheco; Ethan J. Hartwig; George R. Smoliga; Mary A. Kenney; William T. Golde; Luis L. Rodriguez; Show all 10 Authors
- Source:
- BMC veterinary research 2016 v.12 no.1 pp. 205
- ISSN:
- 1746-6148
- Subject:
- Foot-and-mouth disease virus; T-lymphocytes; acute course; blood serum; foot-and-mouth disease; immune response; immunoglobulin G; immunoglobulin M; interferons; monocytes; neutralization; neutralizing antibodies; steers; vaccination; vaccines; viremia; viruses
- Abstract:
- ... BACKGROUND: In order to investigate host factors associated with the establishment of persistent foot-and-mouth disease virus (FMDV) infection, the systemic response to vaccination and challenge was studied in 47 steers. Eighteen steers that had received a recombinant FMDV A vaccine 2 weeks earlier and 29 non-vaccinated steers were challenged by intra-nasopharyngeal deposition of FMDV A24. For up ...
- DOI:
- 10.1186/s12917-016-0838-x
- PubMed:
- 27634113
- PubMed Central:
- PMC5025598
- CHORUS:
- 10.1186/s12917-016-0838-x
- https://doi.org/10.1186/s12917-016-0838-x