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- Author:
- Jonathan Arzt, et al. ; James J. Zhu; Carolina Stenfeldt; Elizabeth A. Bishop; Jessica A. Canter; Michael Eschbaumer; Luis L. Rodriguez; Show all 7 Authors
- Source:
- Pathogens 2022 v.11 no.8 pp. -
- ISSN:
- 2076-0817
- Subject:
- Foot-and-mouth disease virus; aryl hydrocarbon receptors; cattle; chemokines; foot-and-mouth disease; gene expression regulation; interleukin-6; ligands; mucosa; neutrophils; pharynx
- Abstract:
- ... Foot-and-mouth disease virus (FMDV) can persistently infect pharyngeal epithelia in ruminants but not in pigs. Our previous studies demonstrated that persistent FMDV infection in cattle was associated with under-expression of several chemokines that recruit immune cells. This report focuses on the analysis of differentially expressed genes (DEG) identified during the transitional phase of infectio ...
- DOI:
- 10.3390/pathogens11080822
- https://doi.org/10.3390/pathogens11080822
- Author:
- Jonathan Arzt, et al. ; Haillie C. Meek; Carolina Stenfeldt; Show all 3 Authors
- Source:
- Journal of comparative pathology 2022 v.198 pp. 62-79
- ISSN:
- 0021-9975
- Subject:
- COVID-19 infection; cytotoxicity; esophagus; fluorescent antibody technique; foot-and-mouth disease; immunohistochemistry; light microscopy; mucosa; nasal cavity; nasopharynx; pathogenesis; phenotype
- Abstract:
- ... The mammalian nasopharynx is an anatomically complex region of the upper respiratory tract that directly communicates with the nasal cavity, laryngopharynx, oesophagus and trachea. The nasopharyngeal mucosa contains moderate quantities of mucosa-associated lymphoid tissue (MALT) that is appropriately located for immunological sampling but also creates vulnerability to pathogens. In recent years, t ...
- DOI:
- 10.1016/j.jcpa.2022.07.011
- https://doi.org/10.1016/j.jcpa.2022.07.011
- Author:
- Jonathan Arzt, et al. ; Umanga Gunasekera; Jitendra Kumar Biswal; Gustavo Machado; Rajeev Ranjan; Saravanan Subramaniam; Manoranjan Rout; Jajati Keshari Mohapatra; Bramhadev Pattnaik; Rabindra Prasad Singh; Andres Perez; Kimberly VanderWaal; Show all 12 Authors
- Source:
- Transboundary and emerging diseases 2022 v.69 no.5 pp. e1936
- ISSN:
- 1865-1674
- Subject:
- Bayesian theory; antibodies; autocorrelation; foot-and-mouth disease; models; risk; serotypes; space and time; vaccination; India
- Abstract:
- ... Foot‐and‐mouth disease (FMD) is endemic in India, where circulation of serotypes O, A and Asia1 is frequent. Here, we provide an epidemiological assessment of the ongoing mass vaccination programs in regard to post‐vaccination monitoring and outbreak occurrence. The objective of this study was assessing the contribution of mass vaccination campaigns in reducing the risk of FMD in India from 2008 t ...
- DOI:
- 10.1111/tbed.14528
- https://doi.org/10.1111/tbed.14528
- Author:
- Jonathan Arzt, et al. ; Karla I. Moreno-Torres; Amy H. Delgado; Matthew A. Branan; Shankar Yadav; Carolina Stenfeldt; Show all 6 Authors
- Source:
- Preventive veterinary medicine 2022 v.202 pp. 105615
- ISSN:
- 0167-5877
- Subject:
- RNA; experimental design; foot-and-mouth disease; industry; probability distribution; veterinary medicine; viruses
- Abstract:
- ... The global interconnectedness of the pig-production industry and the diversity of foot-and-mouth disease (FMD) viruses (FMDVs) currently circulating, makes modeling disease spread and control in FMD-free areas challenging. However, advances in experimental design and transmission studies create opportunities to strengthen our understanding and ability to model FMD transmission. In the current stud ...
- DOI:
- 10.1016/j.prevetmed.2022.105615
- CHORUS:
- 10.1016/j.prevetmed.2022.105615
- https://doi.org/10.1016/j.prevetmed.2022.105615
- Author:
- Jonathan Arzt, et al. ; James J. Zhu; Jessica A. Canter; Luis L. Rodriguez; Show all 4 Authors
- Source:
- Veterinary immunology and immunopathology 2020 v.220 pp. 109990
- ISSN:
- 0165-2427
- Subject:
- DNA microarrays; Primates; amino acid sequences; amino acids; binding sites; bioinformatics; cattle; chemotaxis; chickens; epithelium; gene expression regulation; innate immunity; interleukin-8; lungs; mice; multigene family; nasopharynx; neutrophils; nose; palate; phylogeny; promoter regions; sequence alignment; swine; tongue; transcription (genetics); transcription factors; transcriptomics
- Abstract:
- ... In our previous transcriptomic studies using DNA microarray analysis, a probe designed from an unknown expressed sequence tag (EST) showed significant differential gene expression in the pharyngeal epithelia. The objectives of this study are to annotate the gene sequence and compare the gene transcription levels among different bovine tissues based on our published microarray data. The gene transc ...
- DOI:
- 10.1016/j.vetimm.2019.109990
- CHORUS:
- 10.1016/j.vetimm.2019.109990
- https://doi.org/10.1016/j.vetimm.2019.109990
- Author:
- Jonathan Arzt, et al. ; Carolina Stenfeldt; Miranda R. Bertram; Haillie C. Meek; Ethan J. Hartwig; George R. Smoliga; Megan C. Niederwerder; Diego G. Diel; Scott A. Dee; Show all 9 Authors
- Source:
- Transboundary and emerging diseases 2022 v.69 no.1 pp. 72-87
- ISSN:
- 1865-1674
- Subject:
- Foot-and-mouth disease virus; disease prevention; exposure duration; feed contamination; feeds; foot-and-mouth disease; formaldehyde; lactic acid; pathogenicity; pathogens; risk; soybean meal; storage temperature; swine; viability; viruses
- Abstract:
- ... Transboundary movement of animal feed and feed ingredients has been identified as a route for pathogen incursions. While imports of animals and animal‐derived products are highly regulated for the purpose of infectious disease prevention, there has been less consideration of the viability of infectious agents in inanimate products, such as feed. This study investigated the ability of foot‐and‐mout ...
- DOI:
- 10.1111/tbed.14230
- https://doi.org/10.1111/tbed.14230
- Author:
- Jonathan Arzt, et al. ; Ian Fish; Carolina Stenfeldt; Edward Spinard; Gisselle N. Medina; Paul A. Azzinaro; Miranda R. Bertram; Lauren Holinka; George R. Smoliga; Ethan J. Hartwig; Teresa de los Santos; Show all 11 Authors
- Source:
- Pathogens 2022 v.11 no.6 pp. -
- ISSN:
- 2076-0817
- Subject:
- Foot-and-mouth disease virus; cattle; cell culture; genome; genomics; host range; immune evasion; phylogeny; superinfection; virulence; viruses
- Abstract:
- ... Viral recombination contributes to the emergence of novel strains with the potential for altered host range, transmissibility, virulence, and immune evasion. For foot-and-mouth disease virus (FMDV), cell culture experiments and phylogenetic analyses of field samples have demonstrated the occurrence of recombination. However, the frequency of recombination and associated virus–host interactions wit ...
- DOI:
- 10.3390/pathogens11060644
- https://doi.org/10.3390/pathogens11060644
- Author:
- Jonathan Arzt, et al. ; Rachel Palinski; Steven J. Pauszek; John M. Humphreys; Debra P.C. Peters; D. Scott McVey; Angela M. Pelzel‐McCluskey; Justin D. Derner; N. Dylan Burruss; Luis L. Rodriguez; Show all 10 Authors
- Source:
- Ecosphere 2021 v.12 no.10 pp. e03793
- ISSN:
- 2150-8925
- Subject:
- ecology; evaporative demand; genes; genetic variation; genomics; livestock; livestock and meat industry; phylogeny; phylogeography; soil water; spatial data; spring; summer; vesicular stomatitis; viruses; wildlife; Mexico; New Jersey; Western United States
- Abstract:
- ... Vesicular stomatitis (VS) is an arthropod‐borne viral disease that negatively impacts domestic livestock and wildlife hosts, and economically impacts both private animal owners and the commercial livestock industry. Previous phylogenetic studies, based on partial P gene sequences, suggested that outbreak cycles of the virus (VSV) exhibit a two‐phase dynamic (i.e., incursion and expansion). A singl ...
- DOI:
- 10.1002/ecs2.3793
- https://doi.org/10.1002/ecs2.3793
- Author:
- Jonathan Arzt, et al. ; Umanga Gunasekara; Miranda R. Bertram; Do H. Dung; Bui H. Hoang; Nguyen T. Phuong; Vo V. Hung; Nguyen V. Long; Phan Q. Minh; Le T. Vu; Pham V. Dong; Andres Perez; Kimberly VanderWaal; Show all 13 Authors
- Source:
- Viruses 2021 v.13 no.11 pp. -
- ISSN:
- 1999-4915
- Subject:
- Foot-and-mouth disease virus; blood serum; buffaloes; cattle; genetic variation; genomics; monitoring; principal component analysis; Vietnam
- Abstract:
- ... The genetic diversity of foot-and-mouth disease virus (FMDV) poses a challenge to the successful control of the disease, and it is important to identify the emergence of different strains in endemic settings. The objective of this study was to evaluate the sampling of clinically healthy livestock at slaughterhouses as a strategy for genomic FMDV surveillance. Serum samples (n = 11,875) and orophar ...
- DOI:
- 10.3390/v13112203
- https://doi.org/10.3390/v13112203
- Author:
- Jonathan Arzt, et al. ; Michael Eschbaumer; Veronika Dill; Jolene C. Carlson; Carolina Stenfeldt; Peter W. Krug; John M. Hardham; Jacob E. Stegner; Luis L. Rodriguez; Elizabeth Rieder; Show all 10 Authors
- Source:
- Pathogens 2020 v.9 no.2 pp. -
- ISSN:
- 2076-0817
- Subject:
- Foot-and-mouth disease virus; amino acid substitution; biocontainment; blood serum; cattle; foot-and-mouth disease; hooves; necropsy; nose; pathogens; proteinases; risk; swine; vaccines; viral proteins; viral shedding; virulence; viruses
- Abstract:
- ... Inactivated whole-virus vaccines are widely used for the control of foot-and-mouth disease (FMD). Their production requires the growth of large quantities of virulent FMD virus in biocontainment facilities, which is expensive and carries the risk of an inadvertent release of virus. Attenuated recombinant viruses lacking the leader protease coding region have been proposed as a safer alternative fo ...
- DOI:
- 10.3390/pathogens9020129
- https://doi.org/10.3390/pathogens9020129
- Author:
- Jonathan Arzt, et al. ; Carolina Stenfeldt; Miranda Bertram R.; George Smoliga R.; Ethan Hartwig J.; Amy Delgado H.; Show all 6 Authors
- Source:
- Frontiers in veterinary science 2020 v.7 no. pp. -
- ISSN:
- 2297-1769
- Subject:
- Foot-and-mouth disease virus; airborne transmission; cold storage; epithelium; foot-and-mouth disease; infectious disease incubation period; pathogen survival; pathogenesis; pathogenicity; pig carcasses; sentinel animals; swine; virus transmission
- Abstract:
- ... Data-driven modeling of incursions of high-consequence, transboundary pathogens of animals is a critical component of veterinary preparedness. However, simplifying assumptions and excessive use of proxy measures to compensate for gaps in available data may compromise modeled outcomes. The current investigation was prospectively designed to address two major gaps in current knowledge of foot-and-mo ...
- Handle:
- 10113/6987824
- DOI:
- 10.3389/fvets.2020.00334
- https://doi.org/10.3389/fvets.2020.00334
- Author:
- Jonathan Arzt, et al. ; Lauro Velazquez-Salinas; Steven J. Pauszek; Jose Barrera; Benjamin A. Clark; Manuel V. Borca; Antonio Verdugo-Rodriguez; Carolina Stenfeldt; Luis L. Rodriguez; Show all 9 Authors
- Source:
- Journal of virological methods 2019 v.265 pp. 113-116
- ISSN:
- 0166-0934
- Subject:
- DNA-directed RNA polymerase; Vesicular stomatitis New Jersey virus; cell lines; clones; complementary DNA; genes; growth models; nucleoproteins; phosphoproteins; plasmid vectors; signs and symptoms (animals and humans); site-specific recombination; swine; swine diseases; vesicular stomatitis; virulence; viruses
- Abstract:
- ... This study reports the use of a site-specific recombination cloning technique for rapid development of a full-length cDNA clone that can produce infectious vesicular stomatitis New Jersey virus (VSNJV). The full-length genome of the epidemic VSNJV NJ0612NME6 strain was amplified in four overlapping cDNA fragments which were linked together and cloned into a vector plasmid by site-specific recombin ...
- DOI:
- 10.1016/j.jviromet.2019.01.003
- https://doi.org/10.1016/j.jviromet.2019.01.003
- Author:
- Jonathan Arzt, et al. ; Jack Rhyan; Matthew McCollum; Thomas Gidlewski; Moshe Shalev; Gordon Ward; Brenda Donahue; Carolina Stenfeldt; Fawzi Mohamed; Pauline Nol; Ming Deng; Samia Metwally; Mo Salman; Show all 13 Authors
- Source:
- Journal of wildlife diseases 2020 v.56 no.1 pp. 93-104
- ISSN:
- 0090-3558
- Subject:
- Foot-and-mouth disease virus; Odocoileus hemionus; animal diseases; antibodies; deer; disease transmission; foot-and-mouth disease; laboratory experimentation; mortality; myocarditis; pathogenesis; polymerase chain reaction; proteins; serotypes; signs and symptoms (animals and humans); steers; tongue; viral shedding; viruses; wildlife; California
- Abstract:
- ... The only known outbreak of foot-and-mouth disease (FMD) in wildlife in the US occurred in mule deer (Odocoileus hemionus) in California in 1924–25. There is little recorded information on the pathogenesis and epidemiology of the disease in deer in that outbreak. In this experimental study, we compared the susceptibility of mule deer to FMD virus (FMDV) serotype O to that of cattle (Bos taurus). We ...
- Handle:
- 10113/6805078
- DOI:
- 10.7589/2019-03-059
- https://doi.org/10.7589/2019-03-059
- Author:
- Jonathan Arzt, et al. ; Karla I. Moreno-Torres; Barbara P. Brito; . Branan; Luis L. Rodriguez; Amy H. Delgado; Carolina Stenfeldt; Show all 7 Authors
- Source:
- Frontiers in veterinary science 2018 v.5 no.167 pp. -
- ISSN:
- 2297-1769
- Subject:
- Foot-and-mouth disease virus; blood serum; detection limit; direct contact; estimated exposure dose; foot-and-mouth disease; infectious disease incubation period; microbial detection; oral administration; oropharynx; swine; swine diseases; viral load; viral shedding; virus transmission
- Abstract:
- ... The quantitative relationship between the exposure dose of foot-and-mouth disease virus (FMDV) and subsequent infection dynamics has been demonstrated through controlled inoculation studies in various species. However, similar quantitation of viral doses has not been achieved during contact exposure experiments due to the intrinsic difficulty of measuring the virus quantities exchanged between ani ...
- Handle:
- 10113/6471414
- DOI:
- 10.3389/fvets.2018.00167
- PubMed:
- 30079340
- PubMed Central:
- PMC6062637
- CHORUS:
- 10.3389/fvets.2018.00167
- https://doi.org/10.3389/fvets.2018.00167
15. Characterization of transboundary foot‐and‐mouth disease viruses in Nigeria and Cameroon during 2016
- Author:
- Jonathan Arzt, et al. ; David Odion Ehizibolo; Ian H. Fish; Barbara Brito; Miranda R. Bertram; Abdullahi Ardo; Hussaini G. Ularamu; David D. Lazarus; Yiltawe S. Wungak; Chika I. Nwosuh; George R. Smoliga; Ethan J. Hartwig; Steven James Pauszek; Simon Dickmu; Souley Abdoulkadiri; Show all 15 Authors
- Source:
- Transboundary and emerging diseases 2020 v.67 no.3 pp. 1257-1270
- ISSN:
- 1865-1674
- Subject:
- animals; foot-and-mouth disease; genotype; monitoring; pastoralism; phylogeny; risk; serotypes; trade; viruses; Cameroon; Nigeria; Northern Africa
- Abstract:
- ... Continuous surveillance for foot‐and‐mouth disease (FMD) in endemic settings such as West Africa is imperative to support improved local and regional control plans, with the long‐term goal of regional eradication. This paper describes the genetic characterization of FMD viruses (FMDV) obtained from outbreaks in Nigeria (n = 45) and Cameroon (n = 15) during 2016 and from archival samples (n = 3) re ...
- DOI:
- 10.1111/tbed.13461
- https://doi.org/10.1111/tbed.13461
- Author:
- Jonathan Arzt, et al. ; Juan M. Pacheco; Carolina Stenfeldt; Luis L. Rodriguez; Show all 4 Authors
- Source:
- Virology journal 2017 v.14 no.1 pp. 89
- ISSN:
- 1743-422X
- Subject:
- Foot-and-mouth disease virus; aerosols; antigens; cattle; clones; epithelial cells; foot-and-mouth disease; genomics; hosts; lungs; mucosa; mutants; mutation; nasopharynx; pathogenesis; proteinases; transposons; vaccines; viral load; viremia; virulence; viruses
- Abstract:
- ... BACKGROUND: Understanding the mechanisms of attenuation and virulence of foot-and-mouth disease virus (FMDV) in the natural host species is critical for development of next-generation countermeasures such as live-attenuated vaccines. Functional genomics analyses of FMDV have identified few virulence factors of which the leader proteinase (Lₚᵣₒ) is the most thoroughly investigated. Previous work fr ...
- DOI:
- 10.1186/s12985-017-0758-9
- PubMed:
- 28464897
- PubMed Central:
- PMC5414290
- CHORUS:
- 10.1186/s12985-017-0758-9
- https://doi.org/10.1186/s12985-017-0758-9
- Author:
- Jonathan Arzt, et al. ; Umer Farooq; Zaheer Ahmed; Khalid Naeem; Miranda Bertram; Barbara Brito; Carolina Stenfeldt; Steven J. Pauszek; Michael LaRocco; Luis Rodriguez; Show all 10 Authors
- Source:
- Transboundary and emerging diseases 2018 v.65 no.6 pp. 1836-1850
- ISSN:
- 1865-1674
- Subject:
- Bubalus bubalis; Foot-and-mouth disease virus; RNA; antibodies; buffaloes; carrier state; emerging diseases; endemic diseases; farms; foot-and-mouth disease; hosts; longitudinal studies; phylogeny; seroprevalence; serotypes; Pakistan
- Abstract:
- ... The convalescent subclinical carrier state of foot‐and‐mouth disease virus (FMDV) infection has been thoroughly investigated; contrastingly, the subclinical form of new infections of vaccinated and naïve hosts is recognized, but poorly understood. To investigate the natural dynamics of subclinical FMDV infections, a prospective, 12‐month, longitudinal study was conducted in vaccinated Asian buffal ...
- DOI:
- 10.1111/tbed.12963
- CHORUS:
- 10.1111/tbed.12963
- Chorus Open Access:
- 10.1111/tbed.12963
- https://doi.org/10.1111/tbed.12963
- Author:
- Jonathan Arzt, et al. ; Carolina Stenfeldt; George Smoliga; Michael LaRocco; Joseph Gutkoska; Paul Lawrence; Show all 6 Authors
- Source:
- Virology journal 2017 v.14 no.1 pp. 71
- ISSN:
- 1743-422X
- Subject:
- Foot-and-mouth disease virus; acute course; apoptosis; blood serum; cattle; cell proliferation; chronic diseases; foot-and-mouth disease; humans; immune response; lipid metabolism; microRNA; polymerase chain reaction; serotypes; viruses
- Abstract:
- ... BACKGROUND: Changes in the levels of circulating microRNAs (miRNAs) in the serum of humans and animals have been detected as a result of infection with a variety of viruses. However, to date, such a miRNA profiling study has not been conducted for foot-and-mouth disease virus (FMDV) infection. METHODS: The relative abundance of 169 miRNAs was measured in bovine serum collected at three different p ...
- DOI:
- 10.1186/s12985-017-0743-3
- PubMed:
- 28388926
- PubMed Central:
- PMC5384155
- https://doi.org/10.1186/s12985-017-0743-3
- Author:
- Jonathan Arzt, et al. ; George Omondi; Moh A. Alkhamis; Vincent Obanda; Francis Gakuya; Abraham Sangula; Steven Pauszek; Andres Perez; Stephen Ngulu; Richard van Aardt; Kim VanderWaal; Show all 11 Authors
- Source:
- Molecular ecology 2019 v.28 no.11 pp. 2903-2916
- ISSN:
- 0962-1083
- Subject:
- Bayesian theory; Foot-and-mouth disease virus; Syncerus caffer; anthropogenic activities; buffaloes; cattle; epidemiology; genes; hosts; models; monitoring; phylogeography; viruses; wildlife; Kenya; Tanzania; Uganda; Zimbabwe
- Abstract:
- ... Understanding the dynamics of foot‐and‐mouth disease virus (FMDV), an endemic and economically constraining disease, is critical in designing control programmes in Africa. This study investigates the evolutionary epidemiology of SAT1 and SAT2 FMDV in Eastern Africa, as well as between cattle and wild African buffalo. Bayesian phylodynamic models were used to analyse SAT1 and SAT2 VP1 gene segments ...
- DOI:
- 10.1111/mec.15125
- https://doi.org/10.1111/mec.15125
- Author:
- Jonathan Arzt, et al. ; Rajeev Ranjan; Jitendra K. Biswal; Saravanan Subramaniam; Bana B. Dash; Karam P. Singh; Luis L. Rodriguez; Bramhadev Pattnaik; Show all 8 Authors
- Source:
- Tropical animal health and production 2018 v.50 no.5 pp. 1167-1170
- ISSN:
- 0049-4747
- Subject:
- Foot-and-mouth disease virus; RNA; adults; calves; cows; dairy herds; foot-and-mouth disease; pathogenesis; signs and symptoms (animals and humans); viral nonstructural proteins; viruses; India
- Abstract:
- ... Foot-and-mouth disease (FMD) is a highly contagious and economically important, transboundary viral disease of cloven-hoofed animals. It is known that an asymptomatic, persistent FMD virus (FMDV) infection may occur subsequent to acute or subclinical FMDV infection in adult ruminants. However, virus persistence in young calves has not been studied. In the current investigation, FMDV infection para ...
- DOI:
- 10.1007/s11250-018-1518-6
- https://doi.org/10.1007/s11250-018-1518-6