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- Author:
- Juan M. Pacheco‐Vega, et al. ; M. Elena Contreras‐Sillero; Francisco Javier Valdez‐González; Griselda De La Paz‐Rodríguez; Marco A. Cadena‐Roa; Juan C. Bautista‐Covarrubias; Daniel E. Godínez‐Siordia; Show all 7 Authors
- Source:
- Aquaculture research 2020 v.51 no.11 pp. 4410-4420
- ISSN:
- 1355-557X
- Subject:
- Holothuria; Litopenaeus vannamei; biofloc technology; shrimp; survival rate; tanks
- Abstract:
- ... The aim of our study was to optimize the implementation of biofloc technology system (BFT) by proposing a polyculture that integrates sea cucumber (Holothuria inornata) into shrimp (Penaeus vannamei) culture. We evaluated the polyculture of P. vannamei and H. inornata (UR‐SSC) in the same culture unit. In addition, both species were cultured in separate units with recirculation (R‐S and R‐SC) at a ...
- DOI:
- 10.1111/are.14782
- https://doi.org/10.1111/are.14782
- Author:
- Juan M. Pacheco, et al. ; Jonathan Arzt; Carolina Stenfeldt; Luis L. Rodriguez; Show all 4 Authors
- Source:
- Virology journal 2017 v.14 no.1 pp. 89
- ISSN:
- 1743-422X
- Subject:
- Foot-and-mouth disease virus; aerosols; antigens; cattle; clones; epithelial cells; foot-and-mouth disease; genomics; hosts; lungs; mucosa; mutants; mutation; nasopharynx; pathogenesis; proteinases; transposons; vaccines; viral load; viremia; virulence; viruses
- Abstract:
- ... BACKGROUND: Understanding the mechanisms of attenuation and virulence of foot-and-mouth disease virus (FMDV) in the natural host species is critical for development of next-generation countermeasures such as live-attenuated vaccines. Functional genomics analyses of FMDV have identified few virulence factors of which the leader proteinase (Lₚᵣₒ) is the most thoroughly investigated. Previous work fr ...
- DOI:
- 10.1186/s12985-017-0758-9
- PubMed:
- 28464897
- PubMed Central:
- PMC5414290
- CHORUS:
- 10.1186/s12985-017-0758-9
- https://doi.org/10.1186/s12985-017-0758-9
- Author:
- Juan M. Pacheco, et al. ; Tatjana Sitt; Mary Kenney; José Barrera; Mital Pandya; Korin Eckstrom; Megan Warner; Michael LaRocco; Javier Palarea-Albaladejo; David Brake; Elizabeth Rieder; Jonathan Arzt; John W. Barlow; William T. Golde; Show all 14 Authors
- Source:
- Vaccine 2019 v.37 no.42 pp. 6221-6231
- ISSN:
- 0264-410X
- Subject:
- Foot-and-mouth disease virus; Holstein; Mastadenovirus; blood serum; capsid; cattle diseases; coat proteins; field experimentation; foot-and-mouth disease; half life; humoral immunity; neutralizing antibodies; serotypes; steers; subunit vaccines; vaccination; viral shedding
- Abstract:
- ... Foot-and-mouth disease (FMD) is a highly contagious viral infection of cloven hooved animals that continues to cause economic disruption in both endemic countries or when introduced into a formally FMD free country. Vaccines that protect against clinical disease and virus shedding are critical to control FMD. The replication deficient human adenovirus serotype 5 (Ad5) vaccine vector expressing emp ...
- DOI:
- 10.1016/j.vaccine.2019.08.017
- CHORUS:
- 10.1016/j.vaccine.2019.08.017
- https://doi.org/10.1016/j.vaccine.2019.08.017
- Author:
- Juan M. Pacheco-Vega, et al. ; Marco A. Cadena-Roa; Jesús A. Leyva-Flores; O. Iram Zavala-Leal; Elizabeth Pérez-Bravo; Javier M.J. Ruiz-Velazco; Show all 6 Authors
- Source:
- Aquaculture reports 2018 v.11 pp. 24-30
- ISSN:
- 2352-5134
- Subject:
- Lactobacillus plantarum; Litopenaeus vannamei; Schizochytrium; Vibrio; ammonium; bacteria; biofloc technology; growth performance; microalgae; nitrates; nitrites; pH; probiotics; rearing; seawater; shrimp; shrimp culture; sodium carbonate; stocking rate; tanks; water quality
- Abstract:
- ... At present, the Pacific white shrimp Litopenaeus vannamei Boone, 1931, is one of the species with the greatest potential to be reared under biofloc Technology (BFT). Although BFT presents promising culture methods, some of these require improvements in efficiency by the use of native microalgae and bacteria (BFNO) as an alternative to commercial organism probiotics (BFCO). This experiment was deve ...
- DOI:
- 10.1016/j.aqrep.2018.05.003
- https://doi.org/10.1016/j.aqrep.2018.05.003
- Author:
- Juan M. Pacheco, et al. ; Steven I. Rekant; Mark A. Lyons; Jonathan Arzt; Luis L. Rodriguez; Show all 5 Authors
- Source:
- American journal of veterinary research 2016 v.77 no.1 pp. 98-107
- ISSN:
- 0002-9645
- Subject:
- animal welfare; body temperature; disease detection; feed conversion; horses; host range; hosts; monitoring; pregnancy; stress response; surface temperature; thermography; veterinary medicine
- Abstract:
- ... Abnormal body temperature is a major indicator of disease; infrared thermography (IRT) can assess changes in body surface temperature quickly and remotely. This technology can be applied to a myriad of diseases of various etiologies across a wide range of host species in veterinary medicine. It is used to monitor the physiologic status of individual animals, such as measuring feed efficiency or di ...
- DOI:
- 10.2460/ajvr.77.1.98
- https://doi.org/10.2460/ajvr.77.1.98
- Author:
- Juan M. Pacheco-Vega, et al. ; M. del Pilar Sánchez-Saavedra; Marco A. Cadena-Roa; Dariel Tovar-Ramírez; Show all 4 Authors
- Source:
- Journal of applied phycology 2016 v.28 no.4 pp. 2379-2385
- ISSN:
- 0921-8971
- Subject:
- Chaetoceros muelleri; European Union; Litopenaeus vannamei; Mysis; algae; carboxylic ester hydrolases; culture media; enzyme activity; fertilizers; highly unsaturated fatty acids; in vitro digestibility; larvae; nitrogen; shrimp
- Abstract:
- ... The in vitro digestibility of lipids from Chaetoceros muelleri that were cultured in Guillard medium (F/2) and agricultural fertilizer medium (AF/2) and performance index was examined in enzymatic extracts of Litopenaeus vannamei larvae. The highest enzymatic activity (EA) of lipases was observed in Zoea I (1.53 ± 0.14 EA/10 EU) and Mysis I (1.26 ± 0.01 EA/10 EU (EU are units of enzymatic activity ...
- DOI:
- 10.1007/s10811-015-0750-y
- https://doi.org/10.1007/s10811-015-0750-y
- Author:
- Juan M. Pacheco, et al. ; Carolina Stenfeldt; Barbara P. Brito; Karla I. Moreno-Torres; Amy H. Delgado; Luis L. Rodriguez; Jonathan Arzt; Matt A. Branan; Show all 8 Authors
- Source:
- Frontiers in Veterinary Science 2016 v.3 no. pp. 105-118
- ISSN:
- 2297-1769
- Subject:
- Foot-and-mouth disease virus; disease outbreaks; disease transmission; foot-and-mouth disease; infectious disease incubation period; lesions (animal); models; pathogens; prediction; swine; viral shedding; viremia; viruses
- Abstract:
- ... Understanding the quantitative characteristics of a pathogen’s capability to transmit during distinct phases of infection is important to enable accurate predictions of the spread and impact of a disease outbreak. In the current investigation, the potential for transmission of foot-and-mouth disease virus (FMDV) during the incubation (preclinical) period of infection was investigated in seven grou ...
- Handle:
- 10113/5852184
- DOI:
- 10.3389/fvets.2016.00105
- PubMed:
- 27917386
- PubMed Central:
- PMC5116750
- CHORUS:
- 10.3389/fvets.2016.00105
- https://doi.org/10.3389/fvets.2016.00105
- Author:
- Juan M. Pacheco, et al. ; Carolina Stenfeldt; Nagendrakumar B. Singanallur; Helena C. de Carvalho Ferreira; Wilna Vosloo; Luis L. Rodriguez; Jonathan Arzt; Show all 7 Authors
- Source:
- Veterinary microbiology 2015 v.178 no.1-2 pp. 50-60
- ISSN:
- 0378-1135
- Subject:
- Foot-and-mouth disease virus; aerosols; direct contact; foot-and-mouth disease; pathogenesis; pharynx; serotypes; sheep; viral shedding; virulence; virus replication; viruses; South East Asia
- Abstract:
- ... Within-host infection dynamics of a recent field isolate of foot-and-mouth disease virus (FMDV), serotype O, topotype South East Asia, lineage Myamar’98 were evaluated in sheep using four different systems for virus exposure. Two novel, simulated natural, inoculation systems consisting of intra-nasopharyngeal (INP) deposition and aerosol inoculation were evaluated in comparison with two convention ...
- Handle:
- 10113/61578
- DOI:
- 10.1016/j.vetmic.2015.04.004
- CHORUS:
- 10.1016/j.vetmic.2015.04.004
- Chorus Open Access:
- 10.1016/j.vetmic.2015.04.004
- https://doi.org/10.1016/j.vetmic.2015.04.004
- Author:
- Juan M. Pacheco, et al. ; Vivian O’Donnell; Lauren G. Holinka; Brenton Sanford; Peter W. Krug; Jolene Carlson; Bo Reese; Guillermo R. Risatti; Douglas P. Gladue; Manuel V. Borca; Show all 10 Authors
- Source:
- Virus research 2016 v.221 pp. 8-14
- ISSN:
- 0168-1702
- Subject:
- African swine fever virus; antibodies; blood; disease control; genes; genomics; macrophages; swine; vaccines; virulence
- Abstract:
- ... African swine fever virus (ASFV) produces a contagious disease of domestic pigs that results in severe economic consequences to the swine industry. Control of the disease has been hampered by the unavailability of vaccines. We recently reported the development of two experimental vaccine strains (ASFV-G-Δ9GL and ASFV-G-ΔMGF) based on the attenuation of the highly virulent and epidemiologically rel ...
- DOI:
- 10.1016/j.virusres.2016.05.014
- CHORUS:
- 10.1016/j.virusres.2016.05.014
- Chorus Open Access:
- 10.1016/j.virusres.2016.05.014
- https://doi.org/10.1016/j.virusres.2016.05.014
- Author:
- Juan M. Pacheco, et al. ; Michael Eschbaumer; Carolina Stenfeldt; Steven I. Rekant; Ethan J. Hartwig; George R. Smoliga; Mary A. Kenney; William T. Golde; Luis L. Rodriguez; Jonathan Arzt; Show all 10 Authors
- Source:
- BMC veterinary research 2016 v.12 no.1 pp. 205
- ISSN:
- 1746-6148
- Subject:
- Foot-and-mouth disease virus; T-lymphocytes; acute course; blood serum; foot-and-mouth disease; immune response; immunoglobulin G; immunoglobulin M; interferons; monocytes; neutralization; neutralizing antibodies; steers; vaccination; vaccines; viremia; viruses
- Abstract:
- ... BACKGROUND: In order to investigate host factors associated with the establishment of persistent foot-and-mouth disease virus (FMDV) infection, the systemic response to vaccination and challenge was studied in 47 steers. Eighteen steers that had received a recombinant FMDV A vaccine 2 weeks earlier and 29 non-vaccinated steers were challenged by intra-nasopharyngeal deposition of FMDV A24. For up ...
- DOI:
- 10.1186/s12917-016-0838-x
- PubMed:
- 27634113
- PubMed Central:
- PMC5025598
- CHORUS:
- 10.1186/s12917-016-0838-x
- https://doi.org/10.1186/s12917-016-0838-x
- Author:
- Juan M. Pacheco, et al. ; Jared R. Patch; Mary Kenney; Marvin J. Grubman; William T. Golde; Show all 5 Authors
- Source:
- Viral Immunology 2013 v.26 no.4 pp. 239-249
- Subject:
- Adenoviridae; Foot-and-mouth disease virus; antigens; cell-mediated immunity; cross reaction; cytotoxic T-lymphocytes; foot-and-mouth disease; genetic vectors; major histocompatibility complex; neutralizing antibodies; recombinant vaccines; swine; vaccination; viral shedding; viremia; viruses
- Abstract:
- ... Foot-and-mouth disease (FMD) is an economically important disease of cloven-hoofed animals that remains a global threat to livestock species. The induction of neutralizing antibodies against FMD virus (FMDV) has been the central goal of vaccination efforts against this disease. Although these efforts have yielded much success, challenges remain including lack of cross-neutralizing antibodies, poor ...
- Handle:
- 10113/59460
- DOI:
- 10.108/vim.2013.0011
- https://doi.org/10.108/vim.2013.0011
- Author:
- Juan M. Pacheco, et al. ; Paul Lawrence; Sabena Uddowla; Jason Hollister; Abhay Kotecha; Elizabeth Fry; Elizabeth Rieder; Show all 7 Authors
- Source:
- Virology 2013 v.436 no.1 pp. 150-161
- ISSN:
- 0042-6822
- Subject:
- Foot-and-mouth disease virus; antibodies; antigen detection; antigen-antibody reactions; cattle; cattle diseases; cell culture; disease models; epitopes; foot-and-mouth disease; host-pathogen relationships; hosts; immune system; mutagenesis; neutralization; pathogenesis; phenotype; recombinant antigens; viral antigens; viral proteins; virulence; virus replication
- Abstract:
- ... Foot-and-mouth disease virus (FMDV) VP1 G–H loop contains the major antigenic site. By replacing the sequence upstream of the RGD motif with a FLAG epitope, a marker virus for pathogenesis studies was generated. In cell culture, the recombinant virus containing FLAG (A24-FLAG) exhibited similar plaque phenotypes and growth kinetics to parental virus. A24-FLAG was distinguished, neutralized, and im ...
- Handle:
- 10113/56416
- DOI:
- 10.1016/j.virol.2012.11.001
- https://doi.org/10.1016/j.virol.2012.11.001
- Author:
- Juan M. Pacheco, et al. ; Sabena Uddowla; Jason Hollister; Luis L. Rodriguez; Elizabeth Rieder; Show all 5 Authors
- Source:
- Journal of virology 2012 v.86 no.21 pp. 11675-11685
- ISSN:
- 0022-538X
- Subject:
- Foot-and-mouth disease virus; aerosols; biocontainment; biomarkers; cattle; clones; complementary DNA; control methods; disease control; enzyme-linked immunosorbent assay; fever; foot-and-mouth disease; monoclonal antibodies; mutation; proteins; restriction endonucleases; swine; tongue; vaccination; vaccine development; virus transmission; viruses
- Abstract:
- ... Vaccination of domestic animals with chemically inactivated foot-and-mouth disease virus (FMDV) is widely practiced to control FMD. Currently, FMD vaccine manufacturing requires the growth of large volumes of virulent FMDV in biocontainment-level facilities. Here, two marker FMDV vaccine candidates (A ₂₄LL3D YR and A ₂₄LL3B PVKV3D YR) featuring the deletion of the leader coding region (L ᵖʳᵒ) and ...
- Handle:
- 10113/56422
- DOI:
- 10.1128/JVI.01254-12
- PubMed:
- 22915802
- PubMed Central:
- PMC3486329
- https://doi.org/10.1128/JVI.01254-12
- Author:
- Juan M. Pacheco, et al. ; Meghan Tucker; Ethan Hartwig; Elizabeth Bishop; Jonathan Arzt; Luis L. Rodriguez; Show all 6 Authors
- Source:
- veterinary journal 2012 v.193 no.2 pp. 456-463
- ISSN:
- 1090-0233
- Subject:
- Foot-and-mouth disease virus; direct contact; disease models; disease transmission; exposure duration; foot-and-mouth disease; nose; pathogenesis; saliva; serotypes; swine; viruses
- Abstract:
- ... A novel direct contact transmission model for the study of foot-and-mouth disease virus (FMDV) infection of swine was utilized to investigate transmission characteristics of three FMDV strains belonging to serotypes A, O and Asia1. Each strain demonstrated distinct transmission characteristics and required different exposure times to achieve successful contact transmission. While a 4h exposure was ...
- Handle:
- 10113/55258
- DOI:
- 10.1016/j.tvjl.2012.01.012
- PubMed:
- 22342891
- https://doi.org/10.1016/j.tvjl.2012.01.012
15. Mechanisms of Foot-and-Mouth Disease Virus Tropism Inferred from Differential Tissue Gene Expression
- Author:
- Juan M. Pacheco, et al. ; James J. Zhu; Jonathan Arzt; Michael C. Puckette; George R. Smoliga; Luis L. Rodriguez; Jagadeesh Bayry; Show all 7 Authors
- Source:
- PloS one v.8 no.5 pp. -
- ISSN:
- 1932-6203
- Subject:
- bioinformatics; genes; receptors; extracellular matrix; interferons; virus replication; animals; mouth; tissue distribution; gene expression; viruses; foot-and-mouth disease; pathogenesis; gene expression regulation; fibronectins; tropisms; lesions (animal); interleukin-1; tissue tropism; immune response; Foot-and-mouth disease virus; feet
- Abstract:
- ... Foot-and-mouth disease virus (FMDV) targets specific tissues for primary infection, secondary high-titer replication (e.g. foot and mouth where it causes typical vesicular lesions) and long-term persistence at some primary replication sites. Although integrin αVβ6 receptor has been identified as primary FMDV receptors in animals, their tissue distribution alone fails to explain these highly select ...
- Handle:
- 10113/57141
- DOI:
- 10.1371/journal.pone.0064119
- PubMed:
- 23724025
- PubMed Central:
- PMC3665847
- https://doi.org/10.1371/journal.pone.0064119
- Author:
- Juan M. Pacheco, et al. ; Michael LaRocco; Peter W. Krug; Ed Kramer; Zaheer Ahmed; Hernando Duque; Barry Baxt; Luis L. Rodriguez; Show all 8 Authors
- Source:
- Journal of Clinical Microbiology 2013 v.51 no.6 pp. 1714-1720
- ISSN:
- 1098-660X
- Subject:
- Foot-and-mouth disease virus; cattle; cultured cells; disease resistance; foot-and-mouth disease; gene expression; genetic transduction; integrins; kidney cells; receptors; serotypes; viruses
- Abstract:
- ... Foot-and-mouth disease (FMD) is a worldwide problem limiting the trade of animals and their products from affected countries. The rapid isolation, serotyping, and vaccine matching of FMD virus from disease outbreaks is critical for enabling the implementation of effective vaccination programs and to stop the spread of infection during outbreaks. Some primary cells have been shown to be highly susc ...
- Handle:
- 10113/57157
- DOI:
- 10.1128/JCM.03370-12
- PubMed:
- 23515553
- PubMed Central:
- PMC3716081
- https://doi.org/10.1128/JCM.03370-12
- Author:
- Juan M. Pacheco, et al. ; Sabena Uddowla; Christopher Larson; Elizabeth Bishop; Luis L. Rodriguez; Devendra K. Rai; Jonathan Arzt; Elizabeth Rieder; Show all 8 Authors
- Source:
- Virology 2013 v.447 no.1-2 pp. 172-180
- ISSN:
- 0042-6822
- Subject:
- Bovine rhinitis B virus; Foot-and-mouth disease virus; aerosols; animal disease models; foot-and-mouth disease; host-pathogen relationships; hosts; immune response; in vivo studies; interferons; mutants; neutralization; neutralizing antibodies; pathogenesis; protein synthesis; proteinases; steers; swine; viral proteins; virulence; virus replication; viruses
- Abstract:
- ... Bovine rhinitis B virus (BRBV) shares many motifs and sequence similarities with foot-and-mouth disease virus (FMDV). This study examined if the BRBV leader proteinase (Lᵖʳᵒ) could functionally replace that of FMDV. A mutant A₂₄LBRV3DYR FMDV engineered with the BRBV Lᵖʳᵒ and an antigenic marker in the 3D polymerase exhibited growth properties and eIF4G cleavage similar to parental A₂₄WT virus. The ...
- Handle:
- 10113/59448
- DOI:
- 10.1016/j.virol.2013.08.035
- https://doi.org/10.1016/j.virol.2013.08.035
- Author:
- Juan M. Pacheco, et al. ; Mital Pandya; Elizabeth Bishop; Mary Kenney; Francis Milward; Timothy Doel; William T. Golde; Show all 7 Authors
- Source:
- Vaccine 2012 v.30 no.20 pp. 3106-3111
- ISSN:
- 0264-410X
- Subject:
- Foot-and-mouth disease virus; animal diseases; antigens; cattle; disease outbreaks; dosage; drug delivery systems; fever; inactivated vaccines; lesions (animal); pathogens; vaccination; viremia; viruses
- Abstract:
- ... Foot-and-mouth disease virus (FMDV) causes vesicular disease of cloven-hoofed animals with severe agricultural and economic implications. One of the most highly infectious and contagious livestock pathogens known, the disease spreads rapidly in naïve populations making it critical to have rapidly acting vaccines. Needle inoculation of killed virus vaccine is an efficient method of swiftly vaccinat ...
- Handle:
- 10113/54145
- DOI:
- 10.1016/j.vaccine.2012.02.049
- https://doi.org/10.1016/j.vaccine.2012.02.049
- Author:
- Juan M. Pacheco, et al. ; Jonathan Arzt; George R. Smoliga; Meghan T. Tucker; Elizabeth Bishop; Steven J. Pauszek; Ethan J. Hartwig; Teresa de los Santos; Luis L. Rodriguez; Show all 9 Authors
- Source:
- Virology 2014 v.452-453 pp. 12-22
- ISSN:
- 0042-6822
- Subject:
- Foot-and-mouth disease virus; RNA; aerosols; antiviral properties; avirulent strains; blood; cattle diseases; disease severity; drug delivery systems; epithelial cells; foot-and-mouth disease; immune response; interferons; mutants; pathogenesis; phenotype; steers; virulence; virus replication; viruses
- Abstract:
- ... Early events in the pathogenesis of foot-and-mouth disease virus (FMDV) infection in cattle were investigated through aerosol and intraepithelial lingual (IEL) inoculations of a cDNA-derived FMDV-A₂₄ wild type virus (FMDV-WT) or a mutant derived from the same clone (FMDV-Mut). After aerosolization of FMDV-WT, primary infection sites had significantly greater quantities of FMDV, viral RNA, and type ...
- Handle:
- 10113/59450
- DOI:
- 10.1016/j.virol.2014.01.001
- https://doi.org/10.1016/j.virol.2014.01.001
- Author:
- Juan M. Pacheco, et al. ; Eva Perez-Martin; Marcelo Weiss; Fayna Diaz-San Segundo; Jonathan Arzt; Marvin J. Grubman; Teresa de los Santos; Show all 7 Authors
- Source:
- Journal of virology 2012 v.86 no.8 pp. 4477-4487
- ISSN:
- 0022-538X
- Subject:
- chickens; cattle diseases; antiviral properties; humans; cell culture; cattle; viremia; disease severity; gene expression; mice; Human mastadenovirus C; new family; foot-and-mouth disease; immune response; Foot-and-mouth disease virus; interferons; swine
- Abstract:
- ... Interferons (IFNs) are the first line of defense against viral infections. Although type I and II IFNs have proven effective to inhibit foot-and-mouth disease virus (FMDV) replication in swine, a similar approach had only limited efficacy in cattle. Recently, a new family of IFNs, type III IFN or IFN-λ, has been identified in human, mouse, chicken, and swine. We have identified bovine IFN-λ3 (boIF ...
- Handle:
- 10113/54544
- DOI:
- 10.1128/JVI.06683-11
- PubMed:
- 22301155
- PubMed Central:
- PMC3318609
- https://doi.org/10.1128/JVI.06683-11