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- Kamal, Shaan, et al. Show all 4 Authors
- TheJournal of physical chemistry 2019 v.123 no.4 pp. 825-835
- X-ray diffraction; active sites; catalytic activity; cyclic GMP; energy; enzymes; guanosine monophosphate; ion channels; ligands; molecular dynamics; signal transduction
- ... The enzyme phosphodiesterase 6 (PDE6) is a critical component of the visual signaling pathway and functions to convert cGMP to GMP. The ability of PDE6 to affect cellular cGMP levels leads to deactivation of cGMP-gated ion channels in both rod and cone cells. PDE6 has been difficult to structurally characterize experimentally, though the structures of the closely related PDE5 and a PDE5/6 chimera ...