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- Author:
- Kate J. Claycombe-Larson, et al. ; Amy N. Bundy; Terry Kuntz; Junguk Hur; Kathleen M. Yeater; Shanon Casperson; Dale C. Brunelle; James N. Roemmich; Show all 8 Authors
- Source:
- Journal of nutritional biochemistry 2022 v.108 no. pp. 109088
- ISSN:
- 0955-2863
- Subject:
- RNA; animal models; brain; chemokines; dietary fat; embryogenesis; energy; females; fetal development; gene expression; gene expression regulation; gestational age; high fat diet; males; placenta; protective effect; proteolysis; synapse; transcriptome; ubiquitin; vegetables
- Abstract:
- ... Maternal dietary conditions play a major role in fetal growth and brain development. The primary aim of this study was to determine the effects of 5% of energy substitution by vegetables in a maternal dietary fat on placental and fetal weight and on fetal brain gene expression. Two-month-old female C57BL/6 mice were fed 16% (normal-fat, NF), 45% fat (HF), or HF substituted with vegetables (5% ener ...
- DOI:
- 10.1016/j.jnutbio.2022.109088
- https://doi.org/10.1016/j.jnutbio.2022.109088
- Author:
- Kate J. Claycombe-Larson, et al. ; Wellison J.S. Diniz; Matthew S. Crouse; Joel S. Caton; Amanda K. Lindholm-Perry; Lawrence P. Reynolds; Carl R. Dahlen; Pawel P. Borowicz; Alison K. Ward; Show all 9 Authors
- Source:
- Data in Brief 2022 v.42 pp. 108074
- ISSN:
- 2352-3409
- Subject:
- DNA methylation; bioinformatics; bisulfites; cattle; choline; chromatin; data quality; digestion; energy; epigenetics; fibroblasts; folic acid; gene expression; glucose; methionine; post-translational modification; quality control
- Abstract:
- ... Fetal programming is established early in life, likely through epigenetic mechanisms that control gene expression. Micronutrients can act as epigenetic modifiers (EM) by modulating the genome through mechanisms that include DNA methylation and post-translational modification of chromatin. Among the EM, methionine, choline, folate, and vitamin B₁₂ have been suggested as key players of DNA methylati ...
- DOI:
- 10.1016/j.dib.2022.108074
- CHORUS:
- 10.1016/j.dib.2022.108074
- https://doi.org/10.1016/j.dib.2022.108074
- Author:
- Kate J. Claycombe-Larson, et al. ; Amy Bundy; Elizabeth Black Lance; Diane C. Darland; Shanon L. Casperson; James N. Roemmich; Show all 6 Authors
- Source:
- Journal of nutritional biochemistry 2022 v.99 pp. 108853
- ISSN:
- 0955-2863
- Subject:
- adipose tissue; adiposity; exercise; females; fibroblast growth factors; high fat diet; lactation; males; methylation; noninsulin-dependent diabetes mellitus; obesity; peroxisome proliferator-activated receptor gamma; pregnancy; progeny; protein synthesis; risk; white adipocytes
- Abstract:
- ... Maternal low-protein and postnatal high-fat (HF) diets program offspring obesity and type 2 diabetes mellitus (T2DM) risk by epigenetically reducing beige adipocytes (BAs) via increased G9a protein expression (Histone3 Lysine9 dimethyl transferase), an inhibitor of the BA marker fibroblast growth factor 21 (FGF21). Conversely, offspring exercise reduces fat mass and white adipocytes, but the mecha ...
- DOI:
- 10.1016/j.jnutbio.2021.108853
- CHORUS:
- 10.1016/j.jnutbio.2021.108853
- https://doi.org/10.1016/j.jnutbio.2021.108853
- Author:
- Kate J. Claycombe-Larson, et al. ; Travis Alvine; Dayong Wu; Kalupahana Nishan S; Naima Moustaid-Moussa; James N. Roemmich; Show all 6 Authors
- Source:
- Journal of Nutrition 2020 v.150 no.7 pp. 1693-1704
- ISSN:
- 0022-3166
- Subject:
- Alzheimer disease; energy; inflammasomes; inflammation; liver; macrophages; metabolism; noninsulin-dependent diabetes mellitus; nutrition; risk
- Abstract:
- ... nflammation is largely mediated by immune cells responding to invading pathogens, whereas metabolism is oriented toward producing usable energy for vital cell functions. Immunometabolic alterations are considered key determinants of chronic inflammation, which leads to the development of chronic diseases. Studies have demonstrated that macrophages and the NOD-, LRR-, and pyrin domain-containing pr ...
- DOI:
- 10.1093/jn/nxaa085
- CHORUS:
- 10.1093/jn/nxaa085
- https://doi.org/10.1093/jn/nxaa085
- Author:
- Kate J. Claycombe, et al. ; Archana Dhasarathy; James N. Roemmich; Show all 3 Authors
- Source:
- Molecular Aspects of Medicine 2017 v.54 no. pp. 37-49
- ISSN:
- 0098-2997
- Subject:
- adipocytes; diet; epigenetics; exercise; medicine; obesity
- Abstract:
- ... not required for publication. ...
- Handle:
- 10113/5695471
- DOI:
- 10.1016/j.mam.2016.10.003
- PubMed:
- 27825817
- PubMed Central:
- PMC5357455
- CHORUS:
- 10.1016/j.mam.2016.10.003
- Chorus Open Access:
- 10.1016/j.mam.2016.10.003
- https://doi.org/10.1016/j.mam.2016.10.003
- Author:
- Kate J. Claycombe-Larson, et al. ; Lisa Jahns; Zach Conrad; LuAnn Johnson K.; Leah Whigham D.; Dayong Wu; Show all 6 Authors
- Source:
- Nutrition research 2018 v.52 no. pp. 98-104
- ISSN:
- 0271-5317
- Subject:
- C-reactive protein; biomarkers; blood plasma; carotenoids; chemokine CCL4; fruit consumption; healthy diet; humans; inflammation; interferon-alpha; tumor necrosis factor-alpha; vegetable consumption
- Abstract:
- ... The health benefits of vegetable and fruit (VF) intake include benefits for diseases that have an inflammatory component, although the relationship between VF intake and systemic inflammatory status is unclear due to the lack of comprehensive analysis of inflammatory markers in most studies. Therefore, our hypothesis was that the consumption of carotenoid-rich vegetables and fruits in the diet wou ...
- Handle:
- 10113/6472287
- DOI:
- 10.1016/j.nutres.2018.02.005
- CHORUS:
- 10.1016/j.nutres.2018.02.005
- https://doi.org/10.1016/j.nutres.2018.02.005
- Author:
- Kate J. Claycombe-Larson, et al. ; Danielle Krout; James N. Roemmich; Amy Bundy; Rolando A. Garcia; Lin Yan; Show all 6 Authors
- Source:
- Journal of nutritional biochemistry 2018 v.57 pp. 35-44
- ISSN:
- 0955-2863
- Subject:
- adipocytes; adiposity; cages; diet; exercise; glucose transporters; insulin; insulin resistance; males; mice; noninsulin-dependent diabetes mellitus; obesity; paternity; phosphatidylinositol 3-kinase; progeny; risk; skeletal muscle; weaning
- Abstract:
- ... Paternal obesity increases, while paternal exercise decreases, offspring obesity and type 2 diabetes (T2D) risk; however, no studies have determined whether a paternal high-fat (HF) diet and exercise interact to alter offspring body weight (BW), adiposity and T2D risk. Three-week-old male C57BL/6 mice were fed a normal-fat (NF) diet (16% fat) or an HF diet (45% fat) and assigned to either voluntar ...
- Handle:
- 10113/5974725
- DOI:
- 10.1016/j.jnutbio.2018.03.013
- https://doi.org/10.1016/j.jnutbio.2018.03.013
- Author:
- Kate J. Claycombe, et al. ; Rolando Garcia; James N. Roemmich; Show all 3 Authors
- Source:
- Nutrition and metabolism 2016 v.13 no.24 pp. 1-14
- ISSN:
- 1743-7075
- Subject:
- adipocytes; adipogenesis; animal models; biomarkers; cell culture; comorbidity; gene expression regulation; genes; metabolism; mice; obesity; white adipose tissue
- Abstract:
- ... There is a growing interest in exploiting the induction of beige or “brite” (brown in white) adipocytes (beigeing) to combat obesity and its comorbidities. However, there is some uncertainty regarding the best markers to evaluate the occurrence or magnitude of beigeing in white adipose tissue in the mouse model. Methods: We evaluated the transcript expression of several thermoregulatory genes and ...
- Handle:
- 10113/62645
- DOI:
- 10.1186/s12986-016-0081-2
- PubMed:
- 26997968
- PubMed Central:
- PMC4797138
- https://doi.org/10.1186/s12986-016-0081-2
- Author:
- Kate J. Claycombe, et al. ; Huawei Zeng; Katie M. Reindl; Show all 3 Authors
- Source:
- Journal of nutritional biochemistry 2015 v.26 no.10 pp. 1022-1028
- ISSN:
- 0955-2863
- Subject:
- DNA; DNA damage; apoptosis; butyric acid; caspase-3; cell communication; cell cycle; cell proliferation; colon; colorectal neoplasms; deoxycholic acid; dietary fiber; gene expression; high fat diet; humans; intestinal microorganisms; metabolites; reactive oxygen species; tumor suppressor genes
- Abstract:
- ... Consumption of a high-fat diet causes an increase in bile acid deoxycholic acid (DCA) in colon lumen and colon cancer risk,while butyrate, an intestinal microbiota metabolite of dietary fiber, has been shown to exhibit colon cancer-preventive effects. To distinguish these opposing effects of DCA and butyrate (two major metabolites in colon lumen), we examined the effects of physiologically relevan ...
- Handle:
- 10113/61624
- DOI:
- 10.1016/j.jnutbio.2015.04.007
- https://doi.org/10.1016/j.jnutbio.2015.04.007
- Author:
- Kate J Claycombe, et al. ; Catherine A Brissette; Othman Ghribi; Show all 3 Authors
- Source:
- Journal of nutrition 2015 v.145 no.5 pp. 1109S-1115S
- ISSN:
- 0022-3166
- Subject:
- DNA methylation; cell differentiation; chromatin; chronic diseases; epigenetics; histones; infectious diseases; inflammation; nutrients; nutrition; risk
- Abstract:
- ... Studies have demonstrated that epigenetic changes such as DNA methylation, histone modification, and chromatin remodeling are linked to an increased inflammatory response as well as increased risk of chronic disease development. A few studies have begun to investigate whether dietary nutrients play a beneficial role by modifying or reversing epigenetically induced inflammation. Results of these st ...
- Handle:
- 10113/60865
- DOI:
- 10.3945/jn.114.194639
- PubMed:
- 25833887
- PubMed Central:
- PMC4410493
- CHORUS:
- 10.3945/jn.114.194639
- https://doi.org/10.3945/jn.114.194639
- Author:
- Kate J. Claycombe-Larson, et al. ; Danielle Krout; Anne Schaar; Yuyang Sun; Pramod Sukumaran; James N. Roemmich; Brij B. Singh; Show all 7 Authors
- Source:
- Journal of biological chemistry 2017 v.292 no.50 pp. 20799-20807
- ISSN:
- 1083-351X
- Subject:
- adipocytes; adipose tissue; adiposity; animal disease models; apoptosis; autophagy; blood glucose; calcium channels; energy metabolism; exercise; fat mass index; high fat diet; hypothalamus; insulin resistance; knockout mutants; mice; noninsulin-dependent diabetes mellitus; obesity; skeletal muscle; subcutaneous fat; transient receptor potential channels; visceral fat
- Abstract:
- ... The transient receptor potential canonical channel-1 (TRPC1) is a Ca2+-permeable channel found in key metabolic organs and tissues, including the hypothalamus, adipose tissue, and skeletal muscle. Loss of TRPC1 may alter the regulation of cellular energy metabolism resulting in insulin resistance thereby leading to diabetes. Exercise reduces insulin resistance, but it is not known whether TRPC1 is ...
- Handle:
- 10113/6743205
- DOI:
- 10.1074/jbc.M117.809954
- PubMed:
- 29074621
- PubMed Central:
- PMC5733613
- https://doi.org/10.1074/jbc.M117.809954
- Author:
- Kate J. Claycombe, et al. ; James N. Roemmich; LuAnn Johnson; Emilie E. Vomhof-DeKrey; W. Thomas Johnson; Show all 5 Authors
- Source:
- Journal of nutritional biochemistry 2015 v.26 no.2 pp. 184-189
- ISSN:
- 0955-2863
- Subject:
- risk; lysine; malnutrition; messenger RNA; glucose; adipose tissue; models; oxygen consumption; skeletal muscle; fetal development; succinate dehydrogenase (quinone); cytochrome c; low protein diet; compensatory growth; mitochondria; noninsulin-dependent diabetes mellitus; obesity; heat production; progeny; rats
- Abstract:
- ... Malnutrition during the fetal growth period increases risk for later obesity and type 2 diabetes mellitus (T2DM). We have shown that a prenatal low-protein (8% protein; LP) diet followed by postnatal high-fat (45% fat; HF) diet results in offspring propensity for adipose tissue catch-up growth, obesity and T2DM in Sprague–Dawley rats. Skeletal muscle is the major tissue for insulin-mediated glucos ...
- Handle:
- 10113/60643
- DOI:
- 10.1016/j.jnutbio.2014.10.003
- https://doi.org/10.1016/j.jnutbio.2014.10.003
- Author:
- Kate J. Claycombe, et al. ; J. Alfredo Martínez; Fermín I. Milagro; Kevin L. Schalinske; Show all 4 Authors
- Source:
- Advances in nutrition 2014 v.5 no.1 pp. 71-81
- ISSN:
- 2156-5376
- Subject:
- DNA methylation; adipose tissue; biomarkers; chromatin; drugs; epigenetics; histones; insulin resistance; noninsulin-dependent diabetes mellitus; obesity; people; risk; weight gain; weight loss
- Abstract:
- ... Given the role that the diet and other environmental factors play in the development of obesity and type 2 diabetes, the implication of different epigenetic processes is being investigated. Although it is well known that the environmental factors can cause cell type-dependent epigenetic changes, including DNA methylation, histone tail modifications and chromatin remodeling, the regulation of these ...
- Handle:
- 10113/58310
- DOI:
- 10.3945/an.113.004705
- PubMed:
- 24425725
- PubMed Central:
- PMC3884103
- https://doi.org/10.3945/an.113.004705
- Author:
- Kate J. Claycombe, et al. ; Emilie E. Vomhof-DeKrey; James N. Roemmich; Turk Rhen; Othman Ghribi; Show all 5 Authors
- Source:
- Journal of nutritional biochemistry 2015 v.26 no.7 pp. 729-735
- ISSN:
- 0955-2863
- Subject:
- genes; neonates; heat production; risk; placenta; males; gene expression; low protein diet; females; transcription factors; messenger RNA; pregnancy; progeny; rats; brown adipose tissue; weight loss; protein synthesis; laboratory animals; dams (mothers); birth weight
- Abstract:
- ... Brown adipose tissue (BAT) plays an important role in regulating body weight (BW) by modifying thermogenesis. Maternal low protein (LP) diets reduce offspring birth weight. Increased BAT thermogenesis in utero may be one mechanism for the lower BW. However, whether maternal LP nutrition alters BAT thermogenesis and BW of offspring in utero is not yet known. We fed obese-prone Sprague–Dawley dams 8 ...
- Handle:
- 10113/61097
- DOI:
- 10.1016/j.jnutbio.2015.01.008
- CHORUS:
- 10.1016/j.jnutbio.2015.01.008
- https://doi.org/10.1016/j.jnutbio.2015.01.008
- Author:
- Kate J. Claycombe, et al. ; Emilie E. Vomhof-DeKrey; Rolando Garcia; William Thomas Johnson; Eric Uthus; James N. Roemmich; Show all 6 Authors
- Source:
- Journal of nutritional biochemistry 2016 v.31 pp. 113-121
- ISSN:
- 0955-2863
- Subject:
- adipocytes; adipose tissue; conception; fibroblast growth factors; gene expression; high fat diet; insulin resistance; lactation; liver; lung function; maternal nutrition; messenger RNA; methyltransferases; mitochondria; obesity; oxygen consumption; pregnancy; progeny; protein synthesis; rats; risk; transcription factors
- Abstract:
- ... We have shown that prenatal low-protein (LP) followed by postnatal high-fat (HF) diets result in a rapid increase in subcutaneous adipose tissue (subc-AT) mass in the offspring, contributing to development of obesity and insulin resistance. Studies have shown that a key transcription factor, PR domain containing 16 (PRDM16), and fibroblast growth factor 21 (FGF21) are involved in conversion of pre ...
- Handle:
- 10113/62896
- DOI:
- 10.1016/j.jnutbio.2016.01.008
- https://doi.org/10.1016/j.jnutbio.2016.01.008
- Author:
- Kate J. Claycombe, et al. ; Zhou Zhou; Muraleedharan G. Nair; Show all 3 Authors
- Source:
- Phytomedicine 2012 v.19 no.10 pp. 878-881
- ISSN:
- 0944-7113
- Subject:
- anti-inflammatory activity; secretion; additive effect; C-reactive protein; dose response; drugs; synergism; Prunus cerasus; phytopharmaceuticals; anthocyanins; calcium; adipose tissue; stem cells; chronic diseases; adverse effects; cardiovascular diseases; interleukin-6; inflammation; fruit extracts; cherries
- Abstract:
- ... Studies have shown positive correlations between inflammatory cytokines such as interleukin-6 (IL-6) and the development of chronic diseases including cardiovascular disease by activating C-reactive protein (CRP). Both atorvastatin calcium (lipitor) as well as flavonoid rich fruit such as tart cherry demonstrate potent anti-inflammatory effects on IL-6 secretion. In this study, we investigated whe ...
- Handle:
- 10113/58077
- DOI:
- 10.1016/j.phymed.2012.05.001
- CHORUS:
- 10.1016/j.phymed.2012.05.001
- https://doi.org/10.1016/j.phymed.2012.05.001
- Author:
- Kate J. Claycombe, et al. ; Lin Yan; George L. Graef; LuAnn K. Johnson; Show all 4 Authors
- Source:
- Journal of agricultural and food chemistry 2013 v.61 no.39 pp. 9373-9379
- ISSN:
- 0021-8561
- Subject:
- adiponectin; body fat; casein; chemokines; dietary supplements; enzyme inhibitors; exercise; food intake; glucose; high fat diet; inflammation; insulin; leptin; mice; obesity; plasminogen activator; running (physical activity); soy protein isolate; triacylglycerols; tumor necrosis factor-alpha; weight control; weight gain; weight loss
- Abstract:
- ... The present study investigated the effects of voluntary running and soy supplementation on diet-induced metabolic disturbance and inflammation in male C57BL/6 mice using a 2x2x2 design in which the effects of diet (AIN93G or its modification with 45% calories from fat), activity level (sedentary or running) and protein source (casein or soy protein isolate (SPI)) and their interactions were assess ...
- Handle:
- 10113/58056
- DOI:
- 10.1021/jf401588h
- PubMed:
- 24011182
- https://doi.org/10.1021/jf401588h
- Author:
- Kate J. Claycombe, et al. ; Sang-Woon Choi; J. Alfredo Martinez; Simonetta Friso; Kevin L. Schalinske; Show all 5 Authors
- Source:
- Advances in nutrition 2013 v.4 no.5 pp. 530-532
- ISSN:
- 2156-5376
- Subject:
- DNA methylation; adults; diabetes mellitus; disease course; disease prevention; environmental factors; epigenetics; food composition; gene expression; gene expression regulation; histones; neoplasms; nutrients; nutrition; obesity; pregnancy
- Abstract:
- ... Epigenetics can be defined as inheritable and reversible phenomena that affect gene expression without altering the underlying base pair sequence. Epigenomics is the study of genome-wide epigenetic modifications. Because gene expression changes are critical in both normal development and disease progression, epigenetics is widely applicable to many aspects of biological research. The influences of ...
- DOI:
- 10.3945/an.113.004168
- PubMed:
- 24038247
- PubMed Central:
- PMC3771139
- https://doi.org/10.3945/an.113.004168
- Author:
- Kate J. Claycombe, et al. ; Nishan S. Kalupahana; Naima Moustaid-Moussa; Show all 3 Authors
- Source:
- Molecular aspects of medicine 2012 v.33 no.1 pp. 26-34
- ISSN:
- 0098-2997
- Subject:
- adipose tissue; cytokines; immunity; inflammation; insulin resistance; liver; metabolic syndrome; noninsulin-dependent diabetes mellitus; obesity; pathogenesis; public health; skeletal muscle
- Abstract:
- ... Obesity is a major public health problem in the United States and worldwide. Further, obesity is causally linked to the pathogenesis of insulin resistance, metabolic syndrome and type-2 diabetes (T2D). A chronic low-grade inflammation occurring in adipose tissue is at least in part responsible for the obesity-induced insulin resistance. This adipose tissue inflammation is characterized by changes ...
- Handle:
- 10113/58076
- DOI:
- 10.1016/j.mam.2011.10.011
- https://doi.org/10.1016/j.mam.2011.10.011
- Author:
- Kate J. Claycombe, et al. ; Eric O. Uthus; James N. Roemmich; LuAnn K. Johnson; W. Thomas Johnson; Show all 5 Authors
- Source:
- Journal of nutrition 2013 v.143 no. pp. 1533-1539
- ISSN:
- 1541-6100
- Subject:
- adipocytes; adipose tissue; conception; dietary protein; energy; fat intake; genes; high fat diet; insulin resistance; insulin-like growth factor II; lactation; low protein diet; maternal nutrition; messenger RNA; mitochondrial DNA; obesity; pregnancy; prenatal development; progeny; protein intake; rats; weaning
- Abstract:
- ... Maternal low protein diets during prenatal development contribute to the development of obesity and insulin resistance in offspring. In this study, obese-prone Sprague -Dawley rats were fed diets having either 8% (low protein, LP) or 20% (normal protein, NP) protein for 3-wk prior to conception and throughout pregnancy and lactation. At weaning, their offspring were fed diets for 12 wk having norm ...
- Handle:
- 10113/58304
- DOI:
- 10 3945/in 113.178038
- https://doi.org/10 3945/in 113.178038