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- Author:
- Kathleen L Chan, et al. ; Jong H Kim; Noreen Mahoney; Luisa W Cheng; Nicole Tautges; Kate Scow; Show all 6 Authors
- Source:
- Journal of the science of food and agriculture 2020 v.100 no.6 pp. 2800-2806
- ISSN:
- 0022-5142
- Subject:
- Aspergillus flavus; adverse effects; aflatoxins; antifungal agents; antifungal properties; apples; bioassays; carcinogenicity; corn; food contamination; food matrix; food processing; fungal contamination; fungi; fungicides; grape juice; human health; organic foods; pH; pathogens; sanitation; soil; soil pollution; soil sampling; thiabendazole; tomatoes
- Abstract:
- ... BACKGROUND: Contamination of food or the environment by fungi, especially those resistant to conventional fungicides or drugs, represents a hazard to human health. The objective of this study is to identify safe, natural antifungal agents that can remove fungal pathogens or contaminants rapidly from food and / or environmental sources. RESULTS: Fifteen antifungal compounds (nine benzo derivatives ...
- DOI:
- 10.1002/jsfa.10288
- https://doi.org/10.1002/jsfa.10288
- Author:
- Kathleen L. Chan, et al. ; Jong H. Kim; Christina C. Tam; Luisa W. Cheng; Kirkwood M. Land; Fatih Yildiz; Show all 6 Authors
- Source:
- Cogent food & agriculture 2020 v.6 no.1 pp. 1823593
- ISSN:
- 2331-1932
- Subject:
- Saccharomyces cerevisiae; agriculture; antioxidants; cell walls; chloroquine; toxicity; yeasts
- Abstract:
- ... We would like to comment on a recent study where the redox-modulatory anti-protozoal drug chloroquine has shown to trigger a crosstalk between the antioxidant and cell wall integrity systems in the yeast Saccharomyces cerevisiae. This note discusses the redox-active potential of the natural compound 2-hydroxy-4-methoxybenzaldehyde (2H4M) which could also serve as a potent redox-cycler in fungal (y ...
- DOI:
- 10.1080/23311932.2020.1823593
- CHORUS:
- 10.1080/23311932.2020.1823593
- https://doi.org/10.1080/23311932.2020.1823593
- Author:
- Kathleen L. Chan, et al. ; Jong H. Kim; Luisa W. Cheng; Lisa Tell; Barbara Byrne; Kristin Clothier; Kirkwood Land; Show all 7 Authors
- Source:
- Methods and protocols 2019 v.2 no.31 pp. -
- ISSN:
- 2409-9279
- Subject:
- Aspergillus fumigatus; active ingredients; animal pathogenic fungi; antifungal agents; antifungal properties; antioxidants; benzaldehyde; chemosensitization; cresols; drug design; drug resistance; extra-label drug use; fludioxonil; fungicide resistance; mutants; mycoses; thymol
- Abstract:
- ... Current antifungal interventions have often limited efficiency in treating fungal pathogens, particularly those resistant to commercial drugs or fungicides. Antifungal drug repurposing is an alternative intervention strategy, whereby new utility of various marketed, non-antifungal drugs could be repositioned as novel antifungal agents. In this study, we investigated “chemosensitization” as a metho ...
- Handle:
- 10113/6477322
- DOI:
- 10.3390/mps2020031
- PubMed:
- 31164611
- PubMed Central:
- PMC6632159
- https://doi.org/10.3390/mps2020031
- Author:
- Kathleen L. Chan, et al. ; Jong H. Kim; Noreen Mahoney; Show all 3 Authors
- Source:
- International journal of molecular sciences 2015 v.16 no.11 pp. 26850-26870
- ISSN:
- 1422-0067
- Subject:
- Aspergillus fumigatus; Penicillium; Saccharomyces cerevisiae; antifungal properties; benzaldehyde; carvacrol; cell walls; chemosensitization; fludioxonil; mitogen-activated protein kinase; mitogen-activated protein kinase kinase; mutants; pathogens; structure-activity relationships; thymol; yeasts
- Abstract:
- ... Disruption of cell wall integrity system should be an effective strategy for control of fungal pathogens. To augment the cell wall disruption efficacy of monoterpenoid phenols (carvacrol, thymol), antimycotic potency of benzaldehyde derivatives that can serve as chemosensitizing agents were evaluated against strains of Saccharomyces cerevisiae wild type (WT), slt2∆ and bck1∆ (mutants of the mitoge ...
- Handle:
- 10113/61675
- DOI:
- 10.3390/ijms161125988
- PubMed:
- 26569223
- PubMed Central:
- PMC4661847
- https://doi.org/10.3390/ijms161125988
- Author:
- Kathleen L. Chan, et al. ; Jong H. Kim; Show all 2 Author
- Source:
- Molecules 2014 v.19 no.11 pp. 18448-18464
- ISSN:
- 1420-3049
- Subject:
- Penicillium expansum; Penicillium italicum; antifungal agents; antifungal properties; chemosensitization; disease control; heat; hydrogen peroxide; in vitro studies; kojic acid; minimum inhibitory concentration; mutants; oxidants; oxidation; plant pathogenic fungi; temperature; toxicity
- Abstract:
- ... Oxidative treatment is one of the strategies for preventing Penicillium contamination in crops/foods. The antifungal efficacy of hydrogen peroxide (H2O2; oxidant) was investigated in Penicillium strains by using kojic acid (KA) as a chemosensitizing agent, which can enhance the susceptibility of pathogens to antifungal agents. Co-application of KA with H2O2 (chemosensitization) resulted in the enh ...
- Handle:
- 10113/60059
- DOI:
- 10.3390/molecules191118448
- PubMed:
- 25397736
- https://doi.org/10.3390/molecules191118448
- Author:
- Kathleen L. Chan, et al. ; Jong H. Kim; William Hart-Cooper; Luisa W. Cheng; William J. Orts; Kaj Johnson; Show all 6 Authors
- Source:
- Microbiology Discovery 2016 v.4 no.2 pp. -
- ISSN:
- 2052-6180
- Subject:
- Aspergillus; GRAS substances; antifungal agents; antifungal properties; antioxidants; benzaldehyde; bioassays; carvacrol; drugs; fludioxonil; fungicide resistance; microbial growth; models; mutants; preservatives; standard operating procedures; surfactants; synergism; thymol; vacuoles; yeasts
- Abstract:
- ... Background: Control of fungi is problematic, since effective methods for intervening fungal infection or contamination, especially for those resistant to drugs/fungicides, are often very limited. Generally regarded as safe (GRAS) agents, such as natural compounds or their structural analogs could be potential sources of sustainable antifungal agents. As a proof of concept, antifungal efficacy of t ...
- Handle:
- 10113/5678137
- DOI:
- 10.7243/2052-6180-4-2
- https://doi.org/10.7243/2052-6180-4-2
- Author:
- Kathleen L. Chan, et al. ; Jong H. Kim; Noreen Mahoney; Bruce C. Campbell; Ronald P. Haff; Larry H. Stanker; Show all 6 Authors
- Source:
- Frontiers in microbiology 2014 v.5 pp. 1-12
- ISSN:
- 1664-302X
- Subject:
- Aspergillus flavus; Aspergillus fumigatus; Aspergillus parasiticus; Saccharomyces cerevisiae; adverse effects; antifungal agents; antifungal properties; bioassays; cell walls; fungi; fungicides; heat stress; kojic acid; microbial growth; minimum inhibitory concentration; mitogen-activated protein kinase; mutants; nontoxigenic strains; pathogens; synergism
- Abstract:
- ... The aim of this study was to examine two benzo analogs, octylgallate (OG) and veratraldehyde (VT), as antifungal agents against strains of Aspergillus parasiticus and A.flavus (toxigenic or atoxigenic). Both toxigenic and atoxigenic strains used were capable of producing kojic acid, another cellular secondary product. A. fumigatus was used as a genetic model for this study. When applied independen ...
- Handle:
- 10113/58725
- DOI:
- 10.3389/fmicb.2014.00087
- PubMed:
- 24639673
- PubMed Central:
- PMC3945611
- https://doi.org/10.3389/fmicb.2014.00087
- Author:
- Kathleen L. Chan, et al. ; Jong H. Kim; Bruce C. Campbell; Noreen Mahoney; Ronald P. Haff; Show all 5 Authors
- Source:
- Molecules 2013 v.18 no.2 pp. 1564-1581
- ISSN:
- 1420-3049
- Subject:
- Penicillium griseofulvum; Aspergillus parasiticus; kojic acid; minimum inhibitory concentration; hosts; antifungal agents; hydrogen peroxide; yeasts; cell respiration; animal pathogenic fungi; mitochondria; plant pathogenic fungi; synergism; metabolic inhibitors; electron transport chain; Aspergillus flavus; antifungal properties
- Abstract:
- ... Co-application of certain types of compounds to conventional antimicrobial drugs can enhance the efficacy of the drugs through a process termed chemosensitization. We show that kojic acid (KA), a natural pyrone, is a potent chemosensitizing agent of complex III inhibitors disrupting the mitochondrial respiratory chain in fungi. Addition of KA greatly lowered the minimum inhibitory concentrations o ...
- Handle:
- 10113/56305
- DOI:
- 10.3390/molecules18021564
- PubMed:
- 23353126
- PubMed Central:
- PMC6269749
- https://doi.org/10.3390/molecules18021564
- Author:
- Kathleen L. Chan, et al. ; Jong H. Kim; Ronald P. Haff; Natália C.G. Faria; Maria de L. Martins; Bruce C. Campbell; Show all 6 Authors
- Source:
- Molecules 2013 v.18 pp. 8873-8894
- ISSN:
- 1420-3049
- Subject:
- Cryptococcus (Tremellomycetes); fermentation; energy; glutathione; drugs; superoxide dismutase; models; pyraclostrobin; Saccharomyces cerevisiae; bioassays; phenolic compounds; Candida; yeasts; mutants; synergism; gene deletion; electron transport chain; pathogens; antifungal properties
- Abstract:
- ... Enhanced control of species of Cryptococcus, non-fermentative yeast pathogens, was achieved by chemosensitization through co-application of certain compounds with a conventional antimicrobial drug. The species of Cryptococcus tested showed higher sensitivity to mitochondrial respiratory chain (MRC) inhibition compared to species of Candida. This higher sensitivity results from the inability of Cry ...
- Handle:
- 10113/58703
- DOI:
- 10.3390/molecules18088873
- PubMed:
- 23892633
- PubMed Central:
- PMC6270351
- https://doi.org/10.3390/molecules18088873
10. Targeting the oxidative stress response system of fungi with redox-potent chemosensitizing agents
- Author:
- Kathleen L. Chan, et al. ; Jong H. Kim; Natalia C. G. Faria; M. de L. Martins; Bruce C. Campbell; Show all 5 Authors
- Source:
- Frontiers in microbiology 2012 v.3 no. pp. 1-11
- ISSN:
- 1664-302X
- Subject:
- Aspergillus fumigatus; Saccharomyces cerevisiae; amphotericin B; antifungal properties; antioxidant activity; gene deletion; hydrogen peroxide; itraconazole; mitogen-activated protein kinase; oxidative stress; stress response; thymol; toxicity; yeasts
- Abstract:
- ... The cellular antioxidant system is a target in the antifungal action of amphotericin B (AMB) and itraconazole (ITZ), in filamentous fungi. The sakAΔ mutant of Aspergillus fumigatus, a mitogen-activated protein kinase (MAPK) gene deletion mutant in the antioxidant system, was found to be more sensitive to AMB or ITZ than other A. fumigatus strains, a wild type and a mpkCΔ mutant (a MAPK gene deleti ...
- Handle:
- 10113/57844
- DOI:
- 10.3389/fmicb.2012.00088
- PubMed:
- 22438852
- PubMed Central:
- PMC3305922
- https://doi.org/10.3389/fmicb.2012.00088
- Author:
- Kathleen L. Chan, et al. ; Jong H. Kim; Perng-Kuang Chang; Natália C. G. Faria; Noreen Mahoney; Young K. Kim; Maria de L. Martins; Bruce C. Campbell; Show all 8 Authors
- Source:
- International journal of molecular sciences 2012 v.13 pp. 13867-13880
- ISSN:
- 1422-0067
- Subject:
- Aspergillus fumigatus; adverse effects; amphotericin B; aspergillosis; fermentation; fungicides; humans; hydrogen peroxide; kojic acid; mitogen-activated protein kinase; mutants; pathogens; yeasts
- Abstract:
- ... Natural compounds that pose no significant medical or environmental side effects are potential sources of antifungal agents, either in their nascent form or as structural backbones for more effective derivatives. Kojic acid (KA) is one such compound. It is a natural by-product of fungal fermentation commonly employed by food and cosmetic industries. We show that KA greatly lowers minimum inhibitor ...
- Handle:
- 10113/57830
- DOI:
- 10.3390/ijms131113867
- PubMed:
- 23203038
- PubMed Central:
- PMC3509554
- https://doi.org/10.3390/ijms131113867
- Author:
- Kathleen L. Chan, et al. ; Jong H. Kim; Noreen Mahoney; Russell J. Molyneux; Bruce C. Campbell; Show all 5 Authors
- Source:
- Applied microbiology and biotechnology 2006 v.70 no.6 pp. 735-739
- ISSN:
- 0175-7598
- Subject:
- mycoses; disease control; chemical control; antifungal agents; phenolic compounds; carboxin; drug resistance; antifungal properties; food pathogens; Saccharomyces cerevisiae; Aspergillus niger; Aspergillus flavus; Penicillium expansum; microbial contamination; antioxidant activity; mitochondria; electron transport chain; superoxide dismutase; oxidative stress
- Abstract:
- ... The antioxidative stress-response system is essential to fungi for tolerating exposure to phenolic compounds. We show how this system can be targeted to improve fungal control by using compounds that inhibit the fungal mitochondrial respiratory chain. Targeting mitochondrial superoxide dismutase with selected phenolic acid derivatives (e.g., vanillyl acetone) resulted in a 100- to 1,000-fold great ...
- Handle:
- 10113/16486
- DOI:
- 10.1007/s00253-005-0123-6
- PubMed:
- 16463173
- https://doi.org/10.1007/s00253-005-0123-6