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- KAWALEK, J.C., et al. Show all 2 Author
- Journal of veterinary pharmacology and therapeutics 2010 v.33 no.1 pp. 69-75
- swine; feed conversion; weight gain; drug excretion; bioavailability; somatotropin; recombinant proteins; metabolites; nutrient-drug interactions; creatinine; propranolol; urine; feces; enzyme activity; oral administration; intravenous injection
- ... Kawalek, J.C., Howard, K.D. Effect of recombinant porcine somatotropin (rpST) on drug disposition in swine. J. vet. Pharmacol. Therap.33, 69-75. Treatment of pigs with recombinant porcine somatotropin (rpST) causes a marked increase in feed utilization with increased weight-gain over untreated controls. Physiological parameters such as creatinine clearance were increased by rpST treatment. Clearan ...
- KAWALEK, J.C., et al. Show all 12 Authors
- Journal of veterinary pharmacology and therapeutics 2006 v.29 no.6 pp. 459-467
- in vivo studies; cattle; bioavailability; sulfonamides; dosage; oral administration; solubility; rumen fermentation
- ... The bolus (or oblet) is a dosage form that can be used for the oral administration of pharmaceutical compounds to ruminating species. Unlike traditional tablets, oral boluses may contain quantities of drug on the order of grams rather than milligrams. Due to its size, it is only recently that USP-like in vitro dissolution methods have been developed for this dosage form. However, whether or not th ...