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- Kieran, Dairín, et al. Show all 5 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.51 pp. 20606-20611
- Puma; animal models; apoptosis; disease course; endoplasmic reticulum; humans; longevity; mice; motor neurons; necrosis; neoplasm cells; neoplasms; neurodegenerative diseases; patients; proteasome endopeptidase complex; protein degradation; proteins; quality control
- ... BH3-only proteins couple diverse stress signals to the evolutionarily conserved mitochondrial apoptosis pathway. Previously, we reported that the activation of the BH3-only protein p53-up-regulated mediator of apoptosis (Puma) was necessary and sufficient for endoplasmic reticulum (ER) stress- and proteasome inhibition-induced apoptosis in neuroblastoma and other cancer cells. Defects in protein q ...
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