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- Kim, Hee Ryung, et al. Show all 16 Authors
- Cell 2019 v.177 no.5 pp. 1232-1242.e11
- G-protein coupled receptors; G-proteins; cryo-electron microscopy; crystallography; filters; hormones; mass spectrometry; neurotransmitters; protein isoforms
- ... The activation of G proteins by G protein-coupled receptors (GPCRs) underlies the majority of transmembrane signaling by hormones and neurotransmitters. Recent structures of GPCR-G protein complexes obtained by crystallography and cryoelectron microscopy (cryo-EM) reveal similar interactions between GPCRs and the alpha subunit of different G protein isoforms. While some G protein subtype-specific ...
- Kim, Hee Ryung, et al. Show all 5 Authors
- Archives of pharmacal research 2016 v.39 no.3 pp. 293-301
- G-protein coupled receptors; arrestins; drugs; phosphorylation; phosphotransferases (kinases); signal transduction
- ... G protein-coupled receptors (GPCRs) are a major membrane receptor family with important physiological and pathological functions. In the classical signaling pathway, ligand-activated GPCRs couple to G proteins, thereby inducing G protein-dependent signaling pathways and phosphorylation by G protein-coupled receptor kinases (GRKs). This leads to an interaction with arrestins, which results in GPCR ...