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1. Two transmembrane signaling mechanisms control expression of the cAMP receptor gene CAR1 during Dictyostelium development

Author:
Kimmel, A.R.,   et al.   ; Louis, J.M.; Saxe, C.L. III.;     Show all 3 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 1993 v.90 no.13 pp. 5969-5973
ISSN:
0027-8424
Subject:
cell growth; cyclic AMP; Dictyostelium discoideum; receptors; binding proteins; gene expression; cell differentiation; promoter regions
Abstract:
... Dictyostelium discoideum is among the best characterized organisms for the study of receptor/guanine nucleotide binding protein-mediated control of differentiation. Dictyostelium grow unicellularly but form fully differentiated multicellular organisms through a developmental program regulated by secreted cAMP activating specific cell-surface receptors. Dictyostelium respond differentially to cAMP ...
DOI:
10.1073/pnas.90.13.5969
PubMed:
8392183
PubMed Central:
PMC46848

2. Expression of cAMP-dependent protein kinase in prespore cells is sufficient to induce spore cell differentiation in Dictyostelium

Author:
Kimmel, A.R.,   et al.   ; Mann, S.K.O.; Richardson, D.L.; Lee, S.; Firtel, R.A.;     Show all 5 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 1994 v.91 no.22 pp. 10561-10565
ISSN:
0027-8424
Subject:
spores; sporulation; structural genes; cyclic AMP; Dictyostelium discoideum; gene expression; cell differentiation
Abstract:
... The activity of cAMP-dependent protein kinase (PKA) is required for proper development at several stages during the Dictyostelium life cycle. We present evidence that activation of PKA is rate-limiting for the differentiation of prespore cells to spores and that PKA activation may be the developmental trigger for sporulation. Strains that overexpress the gene encoding the catalytic subunit of PKA ...
DOI:
10.1073/pnas.91.22.10561
PubMed:
7937993
PubMed Central:
PMC45061

3. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity

Author:
Kimmel, A.R.,   et al.   ; Tansey, J.T.; Sztalryd, C.; Gruia-Gray, J.; Roush, D.L.; Zee, J.V.; Gavrilova, O.; Reitman, M.L.; Deng, C.X.; Li, C.;     Show all 10 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2001 v.98 no.11 pp. 6494-6499
ISSN:
0027-8424
Subject:
adipocytes; proteins; messenger RNA; protein synthesis; coatings; glucose; mice; gene expression; lipolysis; obesity; mutants; insulin
Abstract:
... Perilipin coats the lipid droplets of adipocytes and is thought to have a role in regulating triacylglycerol hydrolysis. To study the role of perilipin in vivo, we have created a perilipin knockout mouse. Perilipin null (peri-/-) and wild-type (peri+/+) mice consume equal amounts of food, but the adipose tissue mass in the null animals is reduced to approximately equal to 30% of that in wild-type ...
DOI:
10.1073/pnas.101042998
PubMed:
11371650
PubMed Central:
PMC33496