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- Author:
- Kirkwood M. Land, et al. ; Mendel Friedman; Christina C. Tam; Luisa W. Cheng; Show all 4 Authors
- Source:
- BMC complementary medicine and therapies 2020 v.20 no.1 pp. 271
- ISSN:
- 2662-7671
- Subject:
- Trichomonas vaginalis; Tritrichomonas foetus; alpha-bisabolol; alpha-chaconine; alpha-tomatine; antiprotozoal properties; bioactive compounds; caffeic acid; chlorogenic acid; drug resistance; essential oils; eugenol; foods; grapes; kidney beans; lectins; macroalgae; marine fungi; medicinal plants; medicinal properties; metronidazole; mice; photosensitivity; plant extracts; potato peels; probiotics; quercetin; resveratrol; solanine; theaflavins; trichomoniasis; women
- Abstract:
- ... Human trichomoniasis, caused by the pathogenic parasitic protozoan Trichomonas vaginalis, is the most common non-viral sexually transmitted disease that contributes to reproductive morbidity in affected women and possibly to prostate cancer in men. Tritrichomonas foetus strains cause the disease trichomoniasis in farm animals (cattle, bulls, pigs) and diarrhea in domestic animals (cats and dogs). ...
- Handle:
- 10113/7104840
- DOI:
- 10.1186/s12906-020-03061-9
- https://doi.org/10.1186/s12906-020-03061-9
- Author:
- Kirkwood M. Land, et al. ; Jong H. Kim; Kathleen L. Chan; Christina C. Tam; Luisa W. Cheng; Fatih Yildiz; Show all 6 Authors
- Source:
- Cogent food & agriculture 2020 v.6 no.1 pp. 1823593
- ISSN:
- 2331-1932
- Subject:
- Saccharomyces cerevisiae; agriculture; antioxidants; cell walls; chloroquine; toxicity; yeasts
- Abstract:
- ... We would like to comment on a recent study where the redox-modulatory anti-protozoal drug chloroquine has shown to trigger a crosstalk between the antioxidant and cell wall integrity systems in the yeast Saccharomyces cerevisiae. This note discusses the redox-active potential of the natural compound 2-hydroxy-4-methoxybenzaldehyde (2H4M) which could also serve as a potent redox-cycler in fungal (y ...
- DOI:
- 10.1080/23311932.2020.1823593
- CHORUS:
- 10.1080/23311932.2020.1823593
- https://doi.org/10.1080/23311932.2020.1823593
- Author:
- Kirkwood M. Land, et al. ; Christina C. Tam; Kevin Nguyen; Daniel Nguyen; Sabrina Hamada; Okhun Kwon; Irene Kuang; Steven Gong; Sydney Escobar; Max Liu; Jihwan Kim; Tiffany Hou; Justin Tam; Luisa W. Cheng; Jong H. Kim; Mendel Friedman; Show all 16 Authors
- Source:
- BMC complementary medicine and therapies 2021 v.21 no.1 pp. 229
- ISSN:
- 2662-7671
- Subject:
- Bacillus cereus; Candida albicans; Lactobacillus; Salmonella enterica; Solanum pimpinellifolium; Trichomonas vaginalis; Tritrichomonas foetus; antibacterial properties; antifungal properties; antiprotozoal properties; caffeic acid; chemical composition; chlorogenic acid; color; fruit peels; fruits; glycoalkaloids; leaves; powders; quercetin; stems; tomatoes; vagina; wild relatives
- Abstract:
- ... BACKGROUND: We previously reported that the tomato glycoalkaloid tomatine inhibited the growth of Trichomonas vaginalis strain G3, Tritrichomonas foetus strain D1, and Tritrichomonas foetus-like strain C1 that cause disease in humans and farm and domesticated animals. The increasing prevalence of antibiotic resistance requires development of new tools to enhance or replace medicinal antibiotics. M ...
- Handle:
- 10113/7504415
- DOI:
- 10.1186/s12906-021-03391-2
- https://doi.org/10.1186/s12906-021-03391-2
- Author:
- Kirkwood M. Land, et al. ; Mendel Friedman; Christina C. Tam; Jong H. Kim; Sydney Escobar; Steven Gong; Max Liu; Xuan Yu Mao; Cindy Do; Irene Kuang; Kelvin Boateng; Janica Ha; Megan Tran; Srimanth Alluri; Tam Le; Ryan Leong; Luisa W. Cheng; Show all 17 Authors
- Source:
- Foods 2021 v.10 no.2 pp. -
- ISSN:
- 2304-8158
- Subject:
- Lactobacillus; Solanum lycopersicum var. cerasiforme; Trichomonas vaginalis; Tritrichomonas foetus; antiparasitic properties; assays; cats; cattle; cherry tomatoes; diarrhea; digestive tract; farms; freeze drying; functional foods; humans; infection; metronidazole; parasites; pomace; sexually transmitted diseases; trichomoniasis
- Abstract:
- ... Trichomoniasis in humans, caused by the protozoal parasite Trichomonas vaginalis, is the most common non-viral sexually transmitted disease, while Tritrichomonas foetus causes trichomonosis, an infection of the gastrointestinal tract and diarrhea in farm animals and domesticated cats. As part of an effort to determine the inhibitory effects of plant-based extracts and pure compounds, seven commerc ...
- DOI:
- 10.3390/foods10020230
- https://doi.org/10.3390/foods10020230
- Author:
- Kirkwood M. Land, et al. ; Amandeep Singh; David Zhang; Christina C. Tam; Luisa W. Cheng; Vipan Kumar; Show all 6 Authors
- Source:
- Journal of Organometallic Chemistry 2019 v.896 no. pp. 1-4
- ISSN:
- 0022-328X
- Subject:
- Trichomonas vaginalis; animal pathogens; biological assessment; flora; humans
- Abstract:
- ... Copper-promoted azide-alkyne cycloadditions were attempted to synthesize a series of variedly functionalized 1H-1,2,3-triazole-linked isatin-ferrocene, ferrocenylmethoxy-isatin and isatin-ferrocenyl-chalcone conjugates. The synthesized scaffolds were assayed for their inhibitory activity against T. vaginalis as well as several common normal human flora bacteria. The observed inhibitory activities ...
- Handle:
- 10113/7544559
- DOI:
- 10.1016/j.jorganchem.2019.05.025
- CHORUS:
- 10.1016/j.jorganchem.2019.05.025
- https://doi.org/10.1016/j.jorganchem.2019.05.025
- Author:
- Kirkwood M. Land, et al. ; Prinessa Chellan; Tameryn Stringer; Ajit Shokar; Aaron Au; Christina Tam; Luisa W. Cheng; Gregory S. Smith; Show all 8 Authors
- Source:
- Inorganic Chemistry Communications 2019 v.102 no. pp. 1-4
- ISSN:
- 1387-7003
- Subject:
- Trichomonas vaginalis; antiprotozoal properties; chemistry; flora; mammals; metronidazole; palladium; parasites; patients
- Abstract:
- ... Clinical cases of metronidazole resistant Trichomonas vaginalis infections have spurred interest in drug discovery against this protozoal parasite. We have carried out structure-activity studies using mononuclear palladium(II) complexes containing salicylaldiminato thiosemicarbazones on a patient isolate of Trichomonas vaginalis highly resistant to the FDA-approved drug metronidazole. A small libr ...
- Handle:
- 10113/7325760
- DOI:
- 10.1016/j.inoche.2019.01.033
- CHORUS:
- 10.1016/j.inoche.2019.01.033
- https://doi.org/10.1016/j.inoche.2019.01.033
- Author:
- Kirkwood M. Land, et al. ; Raghu Raj; Vipan Kumar; Show all 3 Authors
- Source:
- RSC advances 2015 v.5 no.101 pp. 82676-82698
- ISSN:
- 2046-2069
- Subject:
- Plasmodium falciparum; active ingredients; chloroquine; drug resistance; etiological agents; malaria; malaria vaccines; nucleic acid hybridization; quinine
- Abstract:
- ... The resistance of Plasmodium falciparum, the causative agent of malaria, against quinine and chloroquine along with the lack of malaria vaccines has encouraged the development of various synthetic strategies towards biologically active scaffolds. An emerging strategy in medicinal chemistry, termed molecular hybridization, involves the covalent fusion of two or more drugs, active compounds, and/or ...
- DOI:
- 10.1039/c5ra16361g
- https://doi.org/10.1039/c5ra16361g
- Author:
- Kirkwood M. Land, et al. ; Mendel Friedman; Vincent Huang; Quincel Quiambao; Sabrina Noritake; Jenny Liu; Ohkun Kwon; Sirisha Chintalapati; Joseph Young; Carol E. Levin; Christina Tam; Luisa W. Cheng; Show all 12 Authors
- Source:
- Journal of agricultural and food chemistry 2018 v.66 no.30 pp. 7942-7947
- ISSN:
- 1520-5118
- Subject:
- Trichomonas vaginalis; Tritrichomonas foetus; alpha-chaconine; bioactive compounds; cats; cattle; chlorogenic acid; fingerlings; food industry; high performance liquid chromatography; human diseases; microorganisms; parasites; phenolic compounds; potato peels; potatoes; powders; quercetin; solanidine; solanine; therapeutics; trichomoniasis; virulent strains; wastes
- Abstract:
- ... Potato peel, a waste product of the potato processing industry, is high in bioactive compounds. We investigated the in vitro antitrichomonad activity of potato peel powders prepared from commercial Russet, red, purple, and fingerling varieties as well as several known potato components, alkaloids and phenolic compounds, against three pathogenic strains of trichomonads. Trichomonas vaginalis is a s ...
- DOI:
- 10.1021/acs.jafc.8b01726
- CHORUS:
- 10.1021/acs.jafc.8b01726
- https://doi.org/10.1021/acs.jafc.8b01726
- Author:
- Kirkwood M. Land, et al. ; Prinessa Chellan; Vicky M. Avery; Sandra Duffy; James A. Triccas; Gayathri Nagalingam; Christina Tam; Luisa W. Cheng; Jenny Liu; Guy J. Clarkson; Isolda Romero-Canelón; Peter J. Sadler; Show all 12 Authors
- Source:
- Chemistry - a European journal 2018 v.24 no.40 pp. 10078-10090
- ISSN:
- 0947-6539
- Subject:
- Mycobacterium tuberculosis; Plasmodium falciparum; Trichomonas vaginalis; antibacterial properties; antibiotic resistance; antiplasmodial properties; aromatic compounds; chloroquine; coordination compounds; gametocytes; hydrophobicity; imines; inhibitory concentration 50; iridium; organometallic compounds; rhodium; ruthenium; sulfadoxine
- Abstract:
- ... Fourteen novel arene RuII, and cyclopentadienyl (Cpx) RhIII and IrIII complexes containing an N,N’-chelated pyridylimino- or quinolylimino ligand functionalized with the antimalarial drug sulfadoxine have been synthesized and characterized, including three by X-ray crystallography. The rhodium and iridium complexes exhibited potent antiplasmodial activity with IC50 values of 0.10–2.0 mm in either ...
- Handle:
- 10113/6764840
- DOI:
- 10.1002/chem.201801090
- https://doi.org/10.1002/chem.201801090
10. An 18S rRNA Workflow for Characterizing Protists in Sewage, with a Focus on Zoonotic Trichomonads
- Author:
- Kirkwood M. Land, et al. ; Julia M. Maritz; Krysta H. Rogers; Tara M. Rock; Nicole Liu; Susan Joseph; Jane M. Carlton; Show all 7 Authors
- Source:
- Microbial ecology 2017 v.74 no.4 pp. 923-936
- ISSN:
- 0095-3628
- Subject:
- Animalia; Cryptosporidium parvum; DNA; Giardia lamblia; Toxoplasma gondii; Trichomonadida; aquatic environment; bacteria; eukaryotic cells; genetic markers; humans; microbiome; protists; ribosomal RNA; sewage; urban areas; New York
- Abstract:
- ... Microbial eukaryotes (protists) are important components of terrestrial and aquatic environments, as well as animal and human microbiomes. Their relationships with metazoa range from mutualistic to parasitic and zoonotic (i.e., transmissible between humans and animals). Despite their ecological importance, our knowledge of protists in urban environments lags behind that of bacteria, largely due to ...
- DOI:
- 10.1007/s00248-017-0996-9
- PubMed:
- 28540488
- PubMed Central:
- PMC5653731
- https://doi.org/10.1007/s00248-017-0996-9
- Author:
- Kirkwood M. Land, et al. ; Julia M. Maritz; Jane M. Carlton; Robert P. Hirt; Show all 4 Authors
- Source:
- Trends in parasitology 2014 v.30 no.7 pp. 333-341
- ISSN:
- 1471-4922
- Subject:
- Dientamoeba fragilis; Pentatrichomonas hominis; Trichomonas vaginalis; birds; farms; host range; human health; humans; invertebrates; parasites; phylogeny
- Abstract:
- ... Trichomonads are common parasites of many vertebrate and invertebrate species, with four species classically recognized as human parasites: Dientamoeba fragilis, Pentatrichomonas hominis, Trichomonas vaginalis, and Trichomonas tenax. The latter two species are considered human-specific; by contrast, D. fragilis and P. hominis have been isolated from domestic and farm mammals, demonstrating a wide ...
- DOI:
- 10.1016/j.pt.2014.05.005
- PubMed:
- 24951156
- PubMed Central:
- PMC7106558
- https://doi.org/10.1016/j.pt.2014.05.005
- Author:
- Kirkwood M. Land, et al. ; Sabrina M. Noritake; Jenny Liu; Sierra Kanetake; Carol E. Levin; Christina Tam; Luisa W. Cheng; Mendel Friedman; Show all 8 Authors
- Source:
- BMC complementary and alternative medicine 2017 v.17 no.1 pp. 461
- ISSN:
- 1472-6882
- Subject:
- Trichomonas vaginalis; Tritrichomonas foetus; Ziziphus; alternative medicine; bacteria; bioactive properties; black tea; cats; cattle; flora; foods; grape seeds; grapes; green tea; high performance liquid chromatography; humans; pathogens; phytopharmaceuticals; pomegranates; secondary metabolites; theaflavins; trichomoniasis
- Abstract:
- ... BACKGROUND: Plants produce secondary metabolites that often possess widespread bioactivity, and are then known as phytochemicals. We previously determined that several phytochemical-rich food-derived preparations were active against pathogenic foodborne bacteria. Trichomonads produce disease (trichomoniasis) in humans and in certain animals. Trichomonads are increasingly becoming resistant to conv ...
- DOI:
- 10.1186/s12906-017-1967-x
- PubMed:
- 28903731
- PubMed Central:
- PMC5598040
- https://doi.org/10.1186/s12906-017-1967-x
- Author:
- Kirkwood M. Land, et al. ; Maureen Gumbo; Richard M. Beteck; Tawanda Mandizvo; Ronnett Seldon; Digby F. Warner; Heinrich C. Hoppe; Michelle Isaacs; Dustin Laming; Christina C. Tam; Luisa W. Cheng; Nicole Liu; Setshaba D. Khanye; Show all 13 Authors
- Source:
- Molecules 2018 v.23 no.8 pp. -
- ISSN:
- 1420-3049
- Subject:
- Mycobacterium tuberculosis; Trichomonas vaginalis; Trypanosoma brucei brucei; amides; animal pathogenic bacteria; antibacterial properties; antibiotics; antitrypanosomal properties; boron compounds; human cell lines; inhibitory concentration 50; microbiome
- Abstract:
- ... Due to the increased interest in their application in the treatment of infectious diseases, boron-containing compounds have received a significant coverage in the literature. Herein, a small set of novel cinnamoly-oxaborole amides were synthesized and screened against nagana Trypanosoma brucei brucei for antitrypanosomal activity. Compound 5g emerged as a new hit with an in vitro IC(50) value of 0 ...
- Handle:
- 10113/6472453
- DOI:
- 10.3390/molecules23082038
- PubMed:
- 30111695
- PubMed Central:
- PMC6222898
- https://doi.org/10.3390/molecules23082038
- Author:
- Kirkwood M. Land, et al. ; Melissa Hopper; Jeong-fil Yun; Bianhua Zhou; Christine Le; Katelin Kehoe; Ryan Le; Ryan Hill; Gregg Jongeward; Anjan Debnath; Liangfang Zhang; Yukiko Miyamoto; Lars Eckmann; Lisa A. Wrischnik; Show all 14 Authors
- Source:
- International journal of antimicrobial agents 2016 v.48 no.6 pp. 690-694
- ISSN:
- 0924-8579
- Subject:
- Trichomonas vaginalis; Tritrichomonas foetus; adverse effects; animal models; anti-infective agents; antioxidant activity; drugs; gold; hemagglutinins; humans; inhibitory concentration 50; mice; oral administration; oxidants; parasites; trichomoniasis
- Abstract:
- ... Trichomoniasis, caused by the protozoan parasite Trichomonas vaginalis, is the most common, non-viral, sexually transmitted infection in the world, but only two closely related nitro drugs are approved for its treatment. New antimicrobials against trichomoniasis remain an urgent need. Several organic gold compounds were tested for activity against T. vaginalis thioredoxin reductase (TrxR) in cell- ...
- DOI:
- 10.1016/j.ijantimicag.2016.09.020
- PubMed:
- 27839893
- PubMed Central:
- PMC5154799
- https://doi.org/10.1016/j.ijantimicag.2016.09.020
15. Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties
- Author:
- Kirkwood M. Land, et al. ; Muneebah Adams; Tameryn Stringer; Carmen De Kock; Peter J. Smith; Nicole Liu; Christina Tam; Luisa W. Cheng; Mathew Njoroge; Kelly Chibale; Gregory S. Smith; Show all 11 Authors
- Source:
- Dalton Trans 2016 v.45 no.47 pp. 19086-19095
- ISSN:
- 1477-9226
- Subject:
- Chinese hamsters; Escherichia coli; Lactobacillus; Plasmodium falciparum; Trichomonas vaginalis; X-ray diffraction; animal ovaries; antimalarials; antiparasitic properties; carbon; cells; chemical structure; cytotoxicity; growth retardation; humans; liver microsomes; microbiome; parasites; pathogens; quinolines; screening; strains
- Abstract:
- ... Bioisosteric ferrocenyl-containing quinolines and ferrocenylamines containing organosilanes and their carbon analogues, were prepared and fully characterised. The molecular structures of two ferrocenyl- containing quinolines, determined using single-crystal X-ray diffraction, revealed that the compounds crystallise in a folded conformation. The compounds were screened for their antiplasmodial acti ...
- Handle:
- 10113/5678136
- DOI:
- 10.1039/C6DT03175G
- https://doi.org/10.1039/C6DT03175G
16. Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics
- Author:
- Kirkwood M. Land, et al. ; Tameryn Stringer; Carmen De Kock; Hajira Guzgay; John Okombo; Jenny Liu; Sierra Kanetake; Jihwan Kim; Christina Tam; Luisa W. Cheng; Peter J. Smith; Denver T. Hendricks; Timothy J. Egan; Gregory S. Smith; Show all 14 Authors
- Source:
- Dalton Transactions 2016 v.45 no.34 pp. 13415-13426
- ISSN:
- 1477-9226
- Subject:
- Plasmodium falciparum; Trichomonas vaginalis; X-ray diffraction; antiparasitic properties; bacteria; cell lines; chemical structure; chloroquine; cytotoxicity; esophagus; in vitro studies; neoplasm cells; neoplasms; parasites; pathogens; polyamines; quinoline; screening
- Abstract:
- ... A series of mono- and multimeric polyamine-containing ferrocenyl complexes containing a quinoline motif were prepared. The complexes were characterised by standard techniques. The molecular structure of the monomeric salicylaldimine derivative was elucidated using single crystal X-ray diffraction and was consistent with the proposed structure. The antiplasmodial activity of the compounds were eval ...
- Handle:
- 10113/63169
- DOI:
- 10.1039/C6DT02685K
- https://doi.org/10.1039/C6DT02685K
- Author:
- Kirkwood M. Land, et al. ; Yvette A. Girard; Krysta H. Rogers; Richard Gerhold; Scott C. Lenaghan; Leslie W. Woods; Nathan Haberkern; Melissa Hopper; Jeff D. Cann; Christine K. Johnson; Show all 10 Authors
- Source:
- International journal for parasitology 2014 v.3 no.1 pp. 32-40
- ISSN:
- 2213-2244
- Subject:
- Columba fasciata; Passeriformes; Trichomonas gallinae; Trichomonas vaginalis; birds; coasts; etiology; mortality; new species; parasites; phylogeny; trichomoniasis; California
- Abstract:
- ... Trichomonas gallinae is a ubiquitous flagellated protozoan parasite, and the most common etiologic agent of epidemic trichomonosis in columbid and passerine species. In this study, free-ranging Pacific Coast band-tailed pigeons (Patagioenas fasciata monilis) in California (USA) were found to be infected with trichomonad protozoa that were genetically and morphologically distinct from T. gallinae. ...
- DOI:
- 10.1016/j.ijppaw.2013.12.002
- PubMed:
- 24918075
- PubMed Central:
- PMC4047957
- https://doi.org/10.1016/j.ijppaw.2013.12.002