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- Kirmani, Nadia, et al. Show all 5 Authors
- Biomaterials 2019 v.192 pp. 475-485
- animal models; drugs; glucagon-like peptide 1; glutamic acid; half life; intravenous injection; lysine; molecular weight; noninsulin-dependent diabetes mellitus; pharmacokinetics; polymers; polypeptides; subcutaneous injection; zwitterions
- ... The clinical utility of many peptide and protein drugs is limited by their short in-vivo half-life. To address this limitation, we report a new class of polypeptide-based materials that have a long plasma circulation time. The design of these polypeptides is motivated by the hypothesis that incorporating a zwitterionic sequence, within an intrinsically disordered polypeptide motif, would impart “s ...
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