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- Koyama, Ryokichi, et al. Show all 5 Authors
- Biochemical and biophysical research communications 2018 v.503 no.3 pp. 1973-1979
- antagonists; binding capacity; calcium; central nervous system; drugs; humans; inhibitory concentration 50; ligands; mice; physiology; polypeptides; rats; schizophrenia; therapeutics; vasoactive intestinal peptide; vasoactive intestinal peptide receptors
- ... Vasoactive intestinal peptide receptor 2 (VIPR2, also known as VPAC2) is a class B G-protein coupled receptor (GPCR) and plays important roles in the physiology of central nervous system (CNS) by interaction with natural ligands; vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP). Because it has been reported that high-expression and/or overactivatio ...
- Koyama, Ryokichi, et al. Show all 9 Authors
- Biochemical and biophysical research communications 2017 v.483 pp. 183-190
- B-lymphocytes; bacteriophages; cytokinesis; drugs; guanosinetriphosphatase; immigration; immunosuppression; inhibitory concentration 50; lymphocyte proliferation; peptides; protein-protein interactions
- ... Dedicator of cytokinesis 2 (DOCK2) is a key molecule for lymphocyte activation and migration. DOCK2 interacts with Ras-related C3 botulinus toxin substrate 1 (Rac1, GTPase) and mediates the GDP-GTP exchange reaction, indicating that inhibitors against protein-protein interaction (PPI) between DOCK2 and Rac1 would be good drug candidates for treating immune-related disorders. Here, we report DOCK2- ...