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- Kramer, Lance R., et al. Show all 7 Authors
- Toxicology 2016
- DNA; Hepatitis B virus; Kupffer cells; alanine transaminase; anti-inflammatory activity; apoptosis; blood serum; carcinogenesis; cell proliferation; cyclins; gene expression; hepatitis B; hepatocytes; inflammation; lipopolysaccharides; liver; liver neoplasms; messenger RNA; mice; mutants; risk factors; transgenic animals; tumor necrosis factor-alpha
- ... Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) inhibits steatosis and inflammation, known risk factors for liver cancer. In this study, the effect of ligand activation of PPARβ/δ in modulating liver tumorigenesis in transgenic hepatitis B virus (HBV) mice was examined. Activation of PPARβ/δ in HBV mice reduced steatosis, the average number of liver foci, and tumor multiplicity. Reduced e ...
- PubMed Central: