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- Ktistakis, Nicholas T.
- Biochimica et biophysica acta 2019
- autophagy; biogenesis; endoplasmic reticulum; proteins
- ... The origin of the autophagosomal membrane started to be debated by scientists working in the field within one year of the modern definition of autophagy in 1963. There is now converging evidence from older and newer studies that the endoplasmic reticulum is involved in formation of autophagosomes. Thus, it is possible to trace from early morphological work - done without the benefit of molecular d ...
- Ktistakis, Nicholas T., et al. Show all 2 Author
- Methods 2015 v.75 pp. 54-60
- autophagy; electron microscopy; fluorescent proteins; image analysis; mammals; space and time
- ... Autophagy is a cytosolic degradative pathway, which through a series of complicated membrane rearrangements leads to the formation of a unique double membrane vesicle, the autophagosome. The use of fluorescent proteins has allowed visualizing the autophagosome formation in live cells and in real time, almost 40years after electron microscopy studies observed these structures for the first time. In ...