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1. Effect of 5-O-Methylhirsutanonol on Nuclear Factor-κB-Dependent Production of NO and Expression of iNOS in Lipopolysaccharide-Induced RAW264.7 Cells

Author:
Kwon, O.H.,   et al.   ; Han, J.M.; Lee, W.S.; Kim, J.R.; Son, J.; Lee, H.J.; Lee, J.J.; Jeona, T.S.;     Show all 8 Authors
Source:
Journal of agricultural and food chemistry 2008 v.56 no.1 pp. 92-98
ISSN:
0021-8561
Subject:
transcription factors; messenger RNA; nitric oxide synthase; aromatic compounds; nitric oxide; reactive oxygen species; macrophages; inflammation; medicinal plants; transcription (genetics); gene expression; low density lipoprotein; Alnus japonica; medicinal properties; antioxidant activity; leaves; nitrous oxide
Abstract:
... Diarylheptanoids are known to have anti-inflammatory and anti-atherosclerotic activities in various cell types, including macrophages. 5-O-Methylhirsutanonol (5-MH) isolated from the leaves of Alnus japonica Steud exhibited the antioxidant activities on Cu2+- and AAPH-mediated low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substances (TBARS) assay as well as the macrop ...
DOI:
10.1021/jf0721085