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- Kwon, Sung-Yun, et al. Show all 9 Authors
- Journal of controlled release 2017 v.268 pp. 166-175
- CD8-positive T-lymphocytes; Human adenovirus C; Human immunodeficiency virus 1; female genitalia; immunization; memory; mucosa; pathogens; respiratory system; vaccine development; vaccines; viruses
- ... The generation of tissue resident memory (TRM) cells at the body surfaces to provide a front line defence against invading pathogens represents an important goal in vaccine development for a wide variety of pathogens. It has been widely assumed that local vaccine delivery to the mucosae is necessary to achieve that aim. Here we characterise a novel micro-needle array (MA) delivery system fabricate ...
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- Kwon, Sung-Yun, et al. Show all 5 Authors
- Vaccine 2015 v.33 no.37 pp. 4691-4698
- CD8-positive T-lymphocytes; Human adenovirus C; Human immunodeficiency virus 1; antigens; immune response; phenotype; vaccination; vaccines; viruses
- ... A simple dissolvable microneedle array (MA) platform has emerged as a promising technology for vaccine delivery, due to needle-free injection with a formulation that preserves the immunogenicity of live viral vectored vaccines dried in the MA matrix. While recent studies have focused largely on design parameters optimized to induce primary CD8+ T cell responses, the hallmark of a vaccine is synony ...
- Kwon, Sung-Yun, et al. Show all 16 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.8 pp. 3041-3046
- CD8-positive T-lymphocytes; Human adenovirus C; Human immunodeficiency virus; Langerhans cells; cell adhesion; cold; cytokines; dermis; epithelial cells; image analysis; immune response; immunization; nucleic acids; pathogens; protein structure; transcription (genetics); viral vaccines; viruses
- ... Stabilization of virus protein structure and nucleic acid integrity is challenging yet essential to preserve the transcriptional competence of live recombinant viral vaccine vectors in the absence of a cold chain. When coupled with needle-free skin delivery, such a platform would address an unmet need in global vaccine coverage against HIV and other global pathogens. Herein, we show that a simple ...
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