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- Author:
- Larry A. Kuehn, et al. ; Johnna L. Baller; Stephen D. Kachman; Matthew L. Spangler; Show all 4 Authors
- Source:
- Journal of animal breeding and genetics 2022 v.139 no.5 pp. 489-501
- ISSN:
- 0931-2668
- Subject:
- beef cattle; genetic correlation; genomics; genotyping; models; pedigree; phenotypic variation; prediction; progeny
- Abstract:
- ... Pooling samples to derive group genotypes can enable the economically efficient use of commercial animals within genetic evaluations. To test a multivariate framework for genetic evaluations using pooled data, simulation was used to mimic a beef cattle population including two moderately heritable traits with varying genetic correlations, genotypes and pedigree data. There were 15 generations (n = ...
- Handle:
- 10113/7858445
- DOI:
- 10.1111/jbg.12727
- https://doi.org/10.1111/jbg.12727
- Author:
- Larry A. Kuehn, et al. ; Warren M. Snelling; R. Mark Thallman; Matthew L. Spangler; Show all 4 Authors
- Source:
- Animals 2022 v.12 no.14 pp. -
- ISSN:
- 2076-2615
- Subject:
- animal health; beef; beef cows; beef production; crossbreds; genomics; heritability; heterosis; homozygosity; mating behavior; methane; occupational health and safety; quantitative traits; reproductive performance
- Abstract:
- ... Programs for sustainable beef production are established, but the specific role of beef cows in these systems is not well defined. This work characterized cows for two traits related to sustainability, cow weight (CW) and cumulative weight weaned (WtW). Cow weight indicates nutrient requirements and enteric methane emissions. Cumulative weight weaned reflects reproductive performance and avoidance ...
- Handle:
- 10113/7839460
- DOI:
- 10.3390/ani12141745
- https://doi.org/10.3390/ani12141745
- Author:
- Larry A. Kuehn, et al. ; Napoleón Vargas Jurado; Ronald M. Lewis; Show all 3 Authors
- Source:
- Journal of animal breeding and genetics 2020 v.137 no.4 pp. 365-373
- ISSN:
- 0931-2668
- Subject:
- Dorper; Romanov; adults; crossbreds; ewes; flocks; heritability; labor; models; multivariate analysis; wool
- Abstract:
- ... Interest in reducing labour costs due to shearing has led to development of breed types that shed their wool naturally. Selection at young ages can facilitate response. Reliability of predictions of adult from lamb wool shedding (WS) is thus key in the design of breeding programmes to increase shedding. Our objectives were to estimate heritabilities and genetic relationships between WS measured on ...
- DOI:
- 10.1111/jbg.12449
- https://doi.org/10.1111/jbg.12449
- Author:
- Larry A Kuehn, et al. ; Johnna L Baller; Stephen D Kachman; Matthew L Spangler; Show all 4 Authors
- Source:
- Journal of Animal Science pp. -
- ISSN:
- 1525-3163
- Subject:
- DNA; beef cattle; beef industry; cost effectiveness; genome; genomics; genotype; genotyping; models; pedigree; phenotype; phenotypic variation; prediction; progeny; quantitative traits; sires
- Abstract:
- ... Economically relevant traits are routinely collected within the commercial segments of the beef industry but are rarely included in genetic evaluations because of unknown pedigrees. Individual relationships could be resurrected with genomics, but this would be costly; therefore, pooling DNA and phenotypic data provide a cost-effective solution. Pedigree, phenotypic, and genomic data were simulated ...
- DOI:
- 10.1093/jas/skaa184
- CHORUS:
- 10.1093/jas/skaa184
- https://doi.org/10.1093/jas/skaa184
- Author:
- Larry A. Kuehn, et al. ; Warren M. Snelling; Jesse L. Hoff; Jeremiah H. Li; Brittney N. Keel; Amanda K. Lindholm-Perry; Joseph K. Pickrell; Show all 7 Authors
- Source:
- Genes 2020 v.11 no.11 pp. -
- ISSN:
- 2073-4425
- Subject:
- Bos; beef; birth weight; genomics; marbling; nucleotide sequences; prediction; single nucleotide polymorphism arrays
- Abstract:
- ... Decreasing costs are making low coverage sequencing with imputation to a comprehensive reference panel an attractive alternative to obtain functional variant genotypes that can increase the accuracy of genomic prediction. To assess the potential of low-pass sequencing, genomic sequence of 77 steers sequenced to >10X coverage was downsampled to 1X and imputed to a reference of 946 cattle representi ...
- DOI:
- 10.3390/genes11111312
- https://doi.org/10.3390/genes11111312
- Author:
- Larry A. Kuehn, et al. ; Gary L. Bennett; John W. Keele; Warren M. Snelling; Aaron M. Dickey; Darrell Light; Robert A. Cushman; Tara G. McDaneld; Show all 8 Authors
- Source:
- Agriculture (Basel) 2021 v.11 no.7 pp. -
- ISSN:
- 2077-0472
- Subject:
- DNA; agriculture; alleles; beef; beef production; cows; genomics; phenomics; retrospective studies; variance
- Abstract:
- ... Phenotypes are necessary for genomic evaluations and management. Sometimes genomics can be used to measure phenotypes when other methods are difficult or expensive. Prolificacy of bulls used in multiple-bull pastures for commercial beef production is an example. A retrospective study of 79 bulls aged 2 and older used 141 times in 4–5 pastures across 4 years was used to estimate repeatability from ...
- DOI:
- 10.3390/agriculture11070603
- https://doi.org/10.3390/agriculture11070603
- Author:
- Larry A. Kuehn, et al. ; Aspen M. Workman; Tara G. McDaneld; Michael L. Clawson; John Dustin Loy; Show all 5 Authors
- Source:
- BMC veterinary research 2019 v.15 no.1 pp. 161
- ISSN:
- 1746-6148
- Subject:
- Bovine coronavirus; Haemophilus somni; antibodies; beef cattle; blood sampling; blood serum; bovine respiratory disease; calves; control methods; crossbreds; disease outbreaks; genes; herds; humoral immunity; longitudinal studies; nose; pathogenesis; pathogens; prospective studies; respiratory tract diseases; risk factors; sequence analysis; strain differences; viral shedding; weaning
- Abstract:
- ... BACKGROUND: Bovine coronavirus (BCV) is associated with respiratory infections in cattle of all ages; however, a temporal study to evaluate the effect of BCV immunity on virus shedding and bovine respiratory disease (BRD) incidence in pre-weaned beef calves has not been reported. Thus, we report here a prospective study in three herds of crossbred beef calves (n = 817) with endemic BCV. Serial blo ...
- DOI:
- 10.1186/s12917-019-1887-8
- PubMed:
- 31118011
- PubMed Central:
- PMC6532244
- CHORUS:
- 10.1186/s12917-019-1887-8
- https://doi.org/10.1186/s12917-019-1887-8
- Author:
- Larry A Kuehn, et al. ; Jonas Oppenheimer; Benjamin D Rosen; Michael P Heaton; Ley Brian L Vander; Wade R Shafer; Fred T Schuetze; Brad Stroud; Jennifer C McClure; Jennifer P Barfield; Harvey D Blackburn; Theodore S Kalbfleisch; Derek M Bickhart; Kimberly M Davenport; Kristen L Kuhn; Richard E Green; Beth Shapiro; Timothy P L Smith; Show all 18 Authors
- Source:
- Journal of Heredity pp. -
- ISSN:
- 0022-1503
- Subject:
- Bison bison; bison; cattle; fauna; genetic variation; genome; genome assembly; haplotypes; hybrids; inheritance (genetics); introgression; males; nucleotide sequences
- Abstract:
- ... Bison are an icon of the American West and an ecologically, commercially, and culturally important species. Despite numbering in the hundreds of thousands today, conservation concerns remain for the species, including the impact on genetic diversity of a severe bottleneck around the turn of the 20th century and genetic introgression from domestic cattle. Genetic diversity and admixture are best ev ...
- DOI:
- 10.1093/jhered/esab003
- CHORUS:
- 10.1093/jhered/esab003
- https://doi.org/10.1093/jhered/esab003
- Author:
- Larry A. Kuehn, et al. ; Eduardo Casas; Guohong Cai; Karen B. Register; Tara G. McDaneld; John D. Neill; Show all 6 Authors
- Source:
- BMC veterinary research 2018 v.14 no.1 pp. 89
- ISSN:
- 1746-6148
- Subject:
- Mycoplasma bovis; alanine; antibodies; bacterial infections; beef cattle; blood serum; calves; chronic exposure; gene expression regulation; glutamic acid; glutamine; high-throughput nucleotide sequencing; histidine; lysine; non-coding RNA; pathogens; proline; proteins; selenocysteine; stop codon; threonine; transfer RNA; valine; veterinary medicine
- Abstract:
- ... BACKGROUND: High throughput sequencing allows identification of small non-coding RNAs. Transfer RNA Fragments are a class of small non-coding RNAs, and have been identified as being involved in inhibition of gene expression. Given their role, it is possible they may be involved in mediating the infection-induced defense response in the host. Therefore, the objective of this study was to identify 5 ...
- DOI:
- 10.1186/s12917-018-1418-z
- PubMed:
- 29534724
- PubMed Central:
- PMC5851088
- https://doi.org/10.1186/s12917-018-1418-z
- Author:
- Larry A. Kuehn, et al. ; Kashly R. Schweer; Stephen D. Kachman; Harvey C. Freetly; John E. Pollak; Matthew L. Spangler; Show all 6 Authors
- Source:
- Journal of animal science 2018 v.96 no.6 pp. 2086-2098
- ISSN:
- 1525-3163
- Subject:
- Bayesian theory; Markov chain; beef cattle; beef industry; bivariate analysis; breeding value; breeds; crossbreds; feed conversion; feed intake; feed prices; genetic variation; genome-wide association study; genotyping; haplotypes; heifers; models; phenotype; quantitative trait loci; single nucleotide polymorphism; sires; steers
- Abstract:
- ... Feed costs comprise the majority of variable expenses in beef cattle systems making feed efficiency an important economic consideration within the beef industry. Due to the expense of recording individual feed-intake phenotypes, a genomic-enabled approach could be advantageous toward improving this economically relevant trait complex. A genome-wide association study (GWAS) was performed using 748 ...
- Handle:
- 10113/6472295
- DOI:
- 10.1093/jas/sky119
- PubMed:
- 29617803
- PubMed Central:
- PMC6095269
- https://doi.org/10.1093/jas/sky119
- Author:
- Larry A. Kuehn, et al. ; Chitko Carol; Carol G. Chitko-McKown; Stacy L. Bierman; Gary L. Bennett; Keith D. DeDonder; Michael D. Apley; Gregory P. Harhay; Michael L. Clawson; Bradley J. White; Robert L. Larson; Sarah F. Capik; Brian V. Lubbers; Show all 13 Authors
- Source:
- Veterinary immunology and immunopathology 2021 v.237 pp. 110274
- ISSN:
- 0165-2427
- Subject:
- cattle; immunopathology; interleukin-6
- Abstract:
- ... Commercially available bovine-specific assays are limited in number, and multiplex assays for this species are rare. Our objective was to develop a multiplex assay for the bovine inflammatory cytokines IL-1β, IL-6, and TNF-α using the Meso Scale Discovery U-PLEX platform. "Do-It-Yourself" ELISA kits that contained polyclonal antibodies, both unlabeled and biotinylated, and the specific recombinant ...
- Handle:
- 10113/7391751
- DOI:
- 10.1016/j.vetimm.2021.110274
- CHORUS:
- 10.1016/j.vetimm.2021.110274
- https://doi.org/10.1016/j.vetimm.2021.110274
- Author:
- Larry A. Kuehn, et al. ; Morgan D. Hayes; Tami M. Brown-Brandl; Roger A. Eigenberg; R. Mark Thallman; Show all 5 Authors
- Source:
- Transactions of the ASABE v.60 no.4 pp. 1301-1311
- ISSN:
- 2151-0032
- Subject:
- Agricultural Research Service; air temperature; ambient temperature; animal pens; average daily gain; body weight; breathing; cattle; cell respiration; color; death; equipment design; feed intake; feedlots; genetics; heat; heat stress; meat animals; mixed breeds; relative humidity; shade; summer; wind speed; zebu; United States
- Abstract:
- ... Heat stress in cattle results in decreased feed intake, lower daily gain, and potentially death in susceptible animals under intense conditions. A study was carried out during the summer of 2013 at the USDA-ARS U.S. Meat Animal Research Center feedlot evaluating the impact of shade on environmental conditions and cattle performance. A novel two-tiered shade was used in half of the 14 pens, each ho ...
- Handle:
- 10113/5801882
- DOI:
- 10.13031/trans.12104
- https://doi.org/10.13031/trans.12104
- Author:
- Larry A. Kuehn, et al. ; Henry A. Paz; Kristin E. Hales; James E. Wells; Harvey C. Freetly; Elaine D, Berry; Michael D. Flythe; Matthew L. Spangler; Samodha C. Fernando; Show all 9 Authors
- Source:
- Journal of animal science 2018 v.96 no.3 pp. 1045-1058
- ISSN:
- 1525-3163
- Subject:
- Lachnospiraceae; Victivallaceae; bacterial communities; beef cattle; biogeochemical cycles; community structure; diet; feed conversion; heifers; microbiome; models; phenotype; regression analysis; ribosomal RNA; rumen; rumen bacteria; sequence analysis; steers
- Abstract:
- ... The importance of the rumen microbiota on nutrient cycling to the animal is well recognized; however, our understanding of the influence of the rumen microbiome composition on feed efficiency is limited. The rumen microbiomes of two large animal cohorts (125 heifers and 122 steers) were characterized to identify specific bacterial members (operational taxonomic units [OTUs]) associated with feed e ...
- Handle:
- 10113/6472203
- DOI:
- 10.1093/jas/skx081
- PubMed:
- 29617864
- PubMed Central:
- PMC6093515
- https://doi.org/10.1093/jas/skx081
- Author:
- Larry A. Kuehn, et al. ; Eduardo Casas; Guohong Cai; Karen B. Register; Tara G. McDaneld; John D. Neill; Show all 6 Authors
- Source:
- Plos One 2016 v.11 no.8 pp. 1-11
- ISSN:
- 1932-6203
- Subject:
- Mycoplasma bovis; antibiotics; antibodies; autumn; bacteria; beef cattle; blood serum; calves; dairy cattle; disease control; enzyme-linked immunosorbent assay; genome; humans; immunoglobulin G; mice; microRNA; seroprevalence; spring; summer; weaning
- Abstract:
- ... The objective of this study was to identify microRNAs associated with a serum antibody response to Mycoplasma bovis in beef cattle. Serum from sixteen beef calves was collected at three points: in summer after calves were born, in fall at weaning, and in the following spring. All sera collected in the summer were ELISA-negative for anti-M. bovis. By the fall, eight animals were seropositive for Ig ...
- Handle:
- 10113/5454527
- DOI:
- 10.1371/journal.pone.0161651
- PubMed:
- 27537842
- PubMed Central:
- PMC4990326
- CHORUS:
- 10.1371/journal.pone.0161651
- https://doi.org/10.1371/journal.pone.0161651
- Author:
- Larry A. Kuehn, et al. ; Aspen M. Workman; Tara G. McDaneld; Michael L. Clawson; Carol G. Chitko-McKown; John Dustin Loy; Show all 6 Authors
- Source:
- American journal of veterinary research 2017 v.78 no.9 pp. 1065-1076
- ISSN:
- 0002-9645
- Subject:
- Bovine coronavirus; antibodies; beef cattle; blood sampling; blood serum; bovine respiratory disease; calves; crossbreds; enzyme-linked immunosorbent assay; feedlots; herds; nose; pathogens; quantitative polymerase chain reaction; respiratory tract diseases; risk; veterinary medicine; weaning
- Abstract:
- ... OBJECTIVE To evaluate the effect of serum antibody abundance against bovine coronavirus (BCV) on BCV shedding and risk of bovine respiratory disease (BRD) in beef calves from birth through the first 5 weeks in a feedlot. ANIMALS 890 natural-service crossbred beef calves from 4 research herds. PROCEDURES Serial blood samples for measurement of serum anti-BCV antibody abundance by an ELISA and nasal ...
- Handle:
- 10113/5799654
- DOI:
- 10.2460/ajvr.78.9.1065
- https://doi.org/10.2460/ajvr.78.9.1065
- Author:
- Larry A. Kuehn, et al. ; Phillip R. Myer; James E. Wells; Timothy P.L. Smith; Harvey C. Freetly; Show all 5 Authors
- Source:
- SpringerPlus 2015 v.4 no. pp. 454
- ISSN:
- 2193-1801
- Subject:
- Butyrivibrio; Oscillospira; Prevotella; Pseudobutyrivibrio; Sphingomonadaceae; average daily gain; body weight; colon; feed conversion; feed intake; fermentation; genes; high-throughput nucleotide sequencing; intestinal microorganisms; microbial communities; nucleotide sequences; ribosomal RNA; rumen microorganisms; species diversity; steers
- Abstract:
- ... Ruminal microbial fermentation plays an essential role in host nutrition, and as a result, the rumen microbiota have been a major focus of research examining bovine feed efficiency. Microbial communities within other sections of the gastrointestinal tract may also be important with regard to feed efficiency, since it is critical to the health and nutrition of the host. The objective of this study ...
- Handle:
- 10113/61315
- DOI:
- 10.1186/s40064-015-1201-6
- PubMed:
- 26322260
- PubMed Central:
- PMC4549364
- https://doi.org/10.1186/s40064-015-1201-6
- Author:
- Larry A. Kuehn, et al. ; Phillip R. Myer; Timothy P. L. Smith; James E. Wells; Harvey C. Freetly; Show all 5 Authors
- Source:
- Plos One 2015 v.10 no.6 pp. -
- ISSN:
- 1932-6203
- Subject:
- Firmicutes; alfalfa hay; cattle feeding; corn; distillers grains; feed conversion; feed intake; feed supplements; genes; high-throughput nucleotide sequencing; humans; liveweight gain; mice; microbiome; nucleotide sequences; ribosomal RNA; rumen bacteria; rumen fluids; steers; urea
- Abstract:
- ... The cattle rumen has a diverse microbial ecosystem that is essential for the host to digest plant material. Extremes in body weight (BW) gain in mice and humans have been associated with different intestinal microbial populations. The objective of this study was to characterize the microbiome of the cattle rumen among steers differing in feed efficiency. Two contemporary groups of steers (n=148 an ...
- Handle:
- 10113/60941
- DOI:
- 10.1371/journal.pone.0129174
- PubMed:
- 26030887
- PubMed Central:
- PMC4451142
- https://doi.org/10.1371/journal.pone.0129174
- Author:
- Larry A. Kuehn, et al. ; John W. Schmidt; Dee Griffin; Dayna M. Brichta-Harhay; Show all 4 Authors
- Source:
- Applied and environmental microbiology 2013 v.79 no.7 pp. 2273-2283
- ISSN:
- 1098-5336
- Subject:
- ceftiofur; antibiotic resistance; hides and skins; herds; feedlots; cattle; humans; feces; plasmids; pulsed-field gel electrophoresis; genes; genotype; genotyping; Escherichia coli; United States
- Abstract:
- ... In the United States, the blaCMY-2 gene contained within incompatibility type A/C (IncA/C) plasmids is frequently identified in extended-spectrum-cephalosporin-resistant (ESCr) Escherichia coli strains from both human and cattle sources. Concerns have been raised that therapeutic use of ceftiofur in cattle may increase the prevalence of ESCr E. coli.We report that herd ESCr E. coli fecal and hide ...
- Handle:
- 10113/56423
- DOI:
- 10.1128/AEM.03592-12
- PubMed:
- 23354706
- PubMed Central:
- PMC3623230
- https://doi.org/10.1128/AEM.03592-12
- Author:
- Larry A. Kuehn, et al. ; K. J. Retallick; R. L. Weaber; M. D. MacNeil; H. L. Bradford; Harvey C. Freetly; Kristin E. Hales; D. W. Moser; W. M. Snelling; R. Mark Thallman; Show all 10 Authors
- Source:
- Journal of animal science 2017 v.95 no.4 pp. 1444-1450
- ISSN:
- 0021-8812
- Subject:
- additive effect; animal growth; animal models; average daily gain; breed differences; calves; covariance; equations; feed conversion; feed intake; feed prices; finishing; genetic correlation; genetic variance; heifers; heterosis; selection response; steers; weaning weight; yearlings; Nebraska
- Abstract:
- ... Feed costs are a major economic expense in finishing and developing cattle; however, collection of feed intake data is costly. Examining relationships among measures of growth and intake, including breed differences, could facilitate selection for efficient cattle. Objectives of this study were to estimate genetic parameters for growth and intake traits and compare indices for feed efficiency to a ...
- Handle:
- 10113/5700711
- DOI:
- 10.2527/jas2016.1260
- https://doi.org/10.2527/jas2016.1260
- Author:
- Larry A. Kuehn, et al. ; Amanda K. Lindholm-Perry; Rebecca J. Kern; Brittney N. Keel; Warren M. Snelling; Harvey C. Freetly; Show all 6 Authors
- Source:
- Frontiers in genetics 2016 v.7 no.127 pp. 1-9
- ISSN:
- 1664-8021
- Subject:
- aldosterone; antigens; beef cattle; coagulation; epithelial cells; feed conversion; feed intake; gene dosage; gene expression; gene expression regulation; heat shock proteins; immune response; microarray technology; multigene family; olfactory receptors; prothrombin; rumen; small intestine; spleen; stress response; transcriptome; ubiquitination; weight gain
- Abstract:
- ... We have previously identified components of the immune system contributing to feed intake and gain in both the rumen and small intestine of beef steers. In this study, we examined the spleen, a major lymphatic organ near the digestive tract, to determine whether it was also contributing to an animal’s feed efficiency status through immune responses. Animals (n=16) that were divergent for gain and ...
- Handle:
- 10113/5661749
- DOI:
- 10.3389/fgene.2016.00127
- PubMed:
- 27504120
- PubMed Central:
- PMC4958634
- https://doi.org/10.3389/fgene.2016.00127