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- Laurenzi, Tommaso, et al. Show all 7 Authors
- Journal of proteomics 2019 v.199 pp. 102-122
- DNA; animal models; animal tissues; gene silencing; gene targeting; genes; ligands; mice; molecular weight; nucleotide sequences; proteins; proteome; proteomics
- ... The complex interactions among proteins and of proteins with small molecular weight protein ligands are overturned every time one of the components of the network is missing. For study purposes, animal models lacking one protein are obtained by experimental manipulation of the genome: in the knocking out approach, a gene is altered through the insertion of an artificial DNA sequence, which halts t ...