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- Lemieux, Michèle, et al. Show all 11 Authors
- Analytical chemistry 2019 v.91 no.14 pp. 8908-8917
- hemagglutinins; immunization; influenza vaccines; neutralizing antibodies; reversed-phase high performance liquid chromatography; sialic acid
- ... Influenza vaccine potency is determined by the quantification of immunologically active hemagglutinin capable of eliciting neutralizing antibodies upon immunization. Currently, the single radial immunodiffusion (SRID) method is the standard in vitro potency assay used for lot release of seasonal inactivated influenza vaccines. Despite the proven usage of SRID, significant limitations such as the t ...
- Lemieux, Michele, et al. Show all 6 Authors
- Vaccine 2012 v.30 no.37 pp. 5506-5511
- Orthomyxoviridae; analysis of variance; hemagglutinins; immune response; immunization; influenza; morbidity; mortality; public health; thermal stability; vaccines; viruses
- ... BACKGROUND: Respiratory infections caused by influenza viruses spread rapidly, resulting in significant annual morbidity and mortality worldwide. Currently, the most effective public health measure against infection is immunisation with an influenza vaccine matching the relevant circulating influenza strains. Although a number of developments in terms of influenza vaccine production, safety and im ...