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- Li, Chang-e, et al. Show all 4 Authors
- Biomaterials 2019 v.192 pp. 579-589
- adsorption; adverse effects; antineoplastic agents; drug delivery systems; emissions; image analysis; ligands; luminescence; patients; ruthenium; staining; toxicity; uterine cervical neoplasms
- ... The effective design of a targeted drug delivery system could improve the therapeutic efficacy of anticancer drugs by reducing their undesirable adsorption and toxic side effects. Here, an RGD-peptide functionalized and bioresponsive ruthenium prodrug (Ru-RGD) was designed for both cancer therapy and clinical diagnosis. This prodrug can be selectively delivered to cervical tumor sites to enhance t ...
- Li, Chang-e, et al. Show all 5 Authors
- Journal of agricultural and food chemistry 2017 v.65 no.22 pp. 4405-4413
- antioxidant activity; apoptosis; caspase-3; cell cycle; chronic diseases; humans; islets of Langerhans; mitochondria; nanoparticles; oxidative stress; palmitic acid; particle size; phycocyanin; protective effect; rats; reactive oxygen species; selenium; signal transduction
- ... Accumulation of palmitic acid (PA) in human bodies could cause damage to pancreatic β cells and lead to chronic diseases by generation of reactive oxygen species (ROS). Therefore, it is of great significance to search for nutrition-available agents with antioxidant activity to protect pancreatic islet cells against PA-induced damage. Phycocyanin (PC) and selenium (Se) have been reported to have ex ...