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1. A novel sensitive colorimetric sensor for Cu2+ based on in situ formation of fluorescent quantum dots with photocatalytic activity

Author:
Li, Guangwen,   et al.   ; Tang, Shurong; Wang, Meili; Li, Zhijun; Tong, Ping; Chen, Qiang; Chen, Jinghua; Zhang, Lan;     Show all 8 Authors
Source:
Biosensors & bioelectronics 2017 v.89 pp. 866-870
ISSN:
0956-5663
Subject:
absorbance; biosensors; colorimetry; copper; fluorescence; glutathione; irradiation; monitoring; oxidation; photocatalysis; quantum dots; sulfhydryl groups; thiols
Abstract:
... This work demonstrates the use of quantum dots (QDs) with photocatalytic activity as a sensitive, inexpensive and rapid colorimetric platform for Cu²⁺ sensing. Based on the simple thiol compound mediated QDs growing method, CdS QDs can be quickly formed in situ, which possess excellent photocatalytic ability for the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to produce a colored product und ...
DOI:
10.1016/j.bios.2016.09.105

2. A  novel label-free and sensitive electrochemical biosensor for Hg2+ based on ligase-mediated formation of DNAzyme

Author:
Li, Guangwen,   et al.   ; Li, Zhijun; You, Xiuhua; Chen, Jinghua; Tang, Shurong;     Show all 5 Authors
Source:
Talanta 2016 v.161 pp. 138-142
ISSN:
0039-9140
Subject:
DNA; biosensors; electrochemistry; electrodes; gold; mercury; oxidation
Abstract:
... A novel label-free electrochemical biosensor for the detection of Hg2+ based on ligase mediated creation of G-quadruplex-hemin DNAzyme has been developed. Firstly, Cp probe was immobilized on the gold electrode surface through Au–SH bond. In the presence of Hg2+, Cp and Ap probes were partly hybridized with the LJ probe respectively through the specific T–Hg2+–T interaction. Then, the adjacent 3′- ...
DOI:
10.1016/j.talanta.2016.08.042

3. A new supramolecular gel via host–guest complexation with cucurbit[8]uril and N-(4-diethylaminobenzyl)chitosan

Author:
Li, Guangwen,   et al.   ; Lin, Youwen; Li, Lifan;     Show all 3 Authors
Source:
Carbohydrate polymers 2013 v.92 no.1 pp. 429-434
ISSN:
0144-8617
Subject:
Cucurbitaceae; benzene; chitosan; drugs; gels; hydrophobicity; nuclear magnetic resonance spectroscopy; physical properties; scanning electron microscopy
Abstract:
... A novel supramolecular gel has been prepared via host–guest interaction between cucurbit[8]uril (Q[8]) and N-(4-diethylaminobenzyl)chitosan (EBCS). The structure of supramolecular gel has been characterized. The spectrum of 1H NMR demonstrated the benzene ring of EBCS is reside inside the hydrophobic cavity of Q[8] and the host–guest interaction between Q[8] and EBCS was the main driving force for ...
DOI:
10.1016/j.carbpol.2012.09.027

4. A signal-on fluorescent aptasensor based on single-stranded DNA-sensitized luminescence of terbium (III) for label-free detection of breast cancer cells

Author:
Li, Guangwen,   et al.   ; Cai, Shuxian; Zhang, Xi; Xia, Yaokun; Chen, Mei; Wu, Dongzhi; Chen, Qiuxiang; Zhang, Jing; Chen, Jinghua;     Show all 9 Authors
Source:
Talanta 2015 v.138 pp. 225-230
ISSN:
0039-9140
Subject:
aptasensors; biocompatibility; breast neoplasms; detection limit; dyes; early diagnosis; fluorescence; neoplasm cells; oligonucleotides; screening; single-stranded DNA; terbium; women
Abstract:
... Breast cancer is the most common type of malignant tumor in women. Recently, it has been shown that detection of breast cancer tumor cells outside the primitive tumor is an effective early diagnosis with great prognostic and clinical utility. For this purpose, we developed a signal-on fluorescence aptasensor for label-free, facile and sensitive detection of MCF-7 breast cancer cells. Due to target ...
DOI:
10.1016/j.talanta.2015.02.056

5. Chromatographic Fingerprint and Quantitative Analysis of Seven Bioactive Compounds of Scutellaria barbata

Author:
Li, Guangwen,   et al.   ; Yao, Hong; Li, Shaoguang; Hu, Juan; Chen, Yan; Huang, Liying; Lin, Jianhua; Lin, Xinhua;     Show all 8 Authors
Source:
Planta medica 2011 v.77 no.4 pp. 388-393
ISSN:
0032-0943
Subject:
Scutellaria; anti-inflammatory agents; apigenin; bioactive properties; high performance liquid chromatography; humans; luteolin; p-coumaric acid; quality control; quantitative analysis; Asia
Abstract:
... Scutellaria barbata D. Don is widely used as a folk antitumor and anti-inflammatory agent in Asia. However, a simple and global quality control method for S. barbata was lacking. In this study, six phenolic compounds, including p-coumaric acid, scutellarin, apigenin 5-O-β-glucopyranoside, luteolin, apigenin and 4′-hydroxywogonin were obtained from S. barbata by phytochemical investigations. The si ...
DOI:
10.1055/s-0030-1250353
PubMed:
20862635

6. Activation of P2X7 receptors in glial satellite cells reduces pain through downregulation of P2X3 receptors in nociceptive neurons

Author:
Li, GuangWen,   et al.   ; Chen, Yong; Zhang, Xiaofei; Wang, Congying; Gu, Yanping; Huang, Li-Yen Mae;     Show all 6 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.43 pp. 16773-16778
ISSN:
0027-8424
Subject:
adenosine triphosphate; agonists; animal injuries; antagonists; cytotoxicity; ganglia; gene expression regulation; nociception; pain; rats; receptors; sensory neurons; small interfering RNA; spinal cord
Abstract:
... Purinergic ionotropic P2X7 receptors (P2X7Rs) are closely associated with excitotoxicity and nociception. Inhibition of P2X7R activation has been considered as a potentially useful strategy to improve recovery from spinal cord injury and reduce inflammatory damage to trauma. The physiological functions of P2X7Rs, however, are poorly understood, even though such information is essential for making ...
DOI:
10.1073/pnas.0801793105
PubMed:
18946042
PubMed Central:
PMC2575495

7. On-Line Screening and Identification of Radical Scavenging Compounds Extracted from Flos Lonicerae by LC-DAD-TOF-MS

Author:
Li, Guangwen,   et al.   ; Chen, Yan; Li, Shaoguang; Lin, Xinhua; Luo, Hongbin; Yao, Hong;     Show all 6 Authors
Source:
Chromatographia 2008 v.68 no.5-6 pp. 327-332
ISSN:
0009-5893
Subject:
Oriental traditional medicine; bioactive properties; chlorogenic acid; chromatography; detectors; free radical scavengers; isomers; rutin; screening; spectrometers
Abstract:
... Flos Lonicerae is commonly used in traditional Chinese medicine. The ethanolic extracts prepared from Flos Lonicerae were used for the rapid evaluation of free radical scavenging activity by using the extracts to clear on-line 2,2'-diphenyl-1-picrylhydrazyl (DPPH·) free radical with LC serving as the separating tool of bioactive compounds, two diode array detectors (DAD) and a time-of-flight mass ...
DOI:
10.1365/s10337-008-0695-2