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- Liang, Xiang-Jing, et al. Show all 24 Authors
- Cell 2019 v.178 no.6 pp. 1478-1492.e20
- RNA; angiogenesis; biomarkers; blood serum; chemoattractants; dimerization; endothelial cells; fibrosis; in vivo studies; leukocytes; ligands; liver; liver cirrhosis; mice; pathogenesis; patients; peroxisome proliferator-activated receptors; screening; therapeutics
- ... Liver fibrosis is a very common condition seen in millions of patients with various liver diseases, and yet no effective treatments are available owing to poorly characterized molecular pathogenesis. Here, we show that leukocyte cell-derived chemotaxin 2 (LECT2) is a functional ligand of Tie1, a poorly characterized endothelial cell (EC)-specific orphan receptor. Upon binding to Tie1, LECT2 interr ...