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- Lin, Caihou, et al. Show all 9 Authors
- Analytical chemistry 2018 v.90 no.17 pp. 10326-10333
- coculture; drug therapy; endothelial cells; genes; niches; spectrometers; stem cells
- ... In this work, we report the direct diagnosing chemoresistance of glioma stem cells (GSCs) during chemotherapy on a biomimetric microsystem that reconstitutes glioma perivascular niches on a chip. Glioma stem cells and endothelial cells were specially cocultured onto the biomimetric system to precisely control stem cell coculture for the proof-of-principle studies. The expression levels of 6-O-meth ...