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- Lin, Chin-Sheng, et al. Show all 4 Authors
- Nutrients 2018 v.10 no.11
- atherosclerosis; cinnamon; clinical trials; death; diet; eating habits; epidemiological studies; fruits; garlic; ginger; inflammation; lipids; nutrients; onions; pepper; protective effect
- ... Cardiovascular disease is one of the leading causes of death and disability in the world. Atherosclerosis, characterized by lipid accumulation and chronic inflammation in the vessel wall, is the main feature of cardiovascular disease. Although the amounts of fruits and vegetables present in the diets vary by country, diets, worldwide, contain large amounts of spices; this may have positive or nega ...
- Lin, Chin-Sheng, et al. Show all 11 Authors
- Journal of agricultural and food chemistry 2017 v.65 no.15 pp. 3141-3150
- cholesterol; epigallocatechin gallate; foam cells; humans; low density lipoprotein; receptors; transcription factor NF-kappa B; transporters
- ... Foam cells are formed when macrophages imbibe low-density lipoprotein (LDL) through scavenger receptors. Here we examined how epigallocatechin-3-gallate (EGCG) influences foam cell formation. We found that EGCG dose-dependently reduced oxidized LDL (oxLDL) uptake in THP-1 (10 μM, 20.0 ± 0.50, p < 0.05) and primary macrophages (134.6 ± 15.6, p < 0.05) and reduced intracellular cholesterol content i ...