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- Long, Jianlin, et al. Show all 11 Authors
- ACS applied materials & interfaces 2017 v.9 no.45 pp. 39152-39164
- Vesiculovirus; angiogenesis; antineoplastic activity; apoptosis; cell proliferation; encapsulation; gene therapy; genes; intraperitoneal injection; metastasis; nanoparticles; neoplasm cells; ovarian neoplasms; paclitaxel; polyethylene glycol; sulfates; transfection
- ... Nanoparticles have great promise for gene delivery. However, the transfection efficiency of nanoparticle-based gene delivery systems is always unsatisfied to meet the requirement of effective gene therapy. Herein, we used low-dosage paclitaxel to enhance a nanoscaled gene delivery system that was self-assembled from N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammoniummethyl sulfate and monomethox ...
- Long, Jianlin, et al. Show all 12 Authors
- RSC advances 2017 v.7 no.52 pp. 32613-32623
- Vesiculovirus; adverse effects; antineoplastic activity; apoptosis; biodegradability; colorectal neoplasms; electrostatic interactions; gene therapy; genes; immune response; interleukin-12; intraperitoneal injection; metastasis; nanoparticles; neoplasm cells; plasmids
- ... Nanoparticles delivering therapeutic genes have promising applications in cancer treatments. Here, we used biodegradable heparin–polyethyleneimine (HPEI) nanoparticles to co-deliver two genes (vesicular stomatitis virus matrix protein, VSVMP; interleukin-12, IL12) for cancer therapy. These HPEI nanoparticles can bind the plasmid expressing VSVMP (pVSVMP) and the plasmid expressing IL12 (pIL12) thr ...