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- Lotta, Luca A., et al. Show all 19 Authors
- Cell 2019 v.177 no.3 pp. 597-607.e9
- G-protein coupled receptors; body mass index; coronary artery disease; cyclic AMP; gain-of-function mutation; humans; mitogen-activated protein kinase; noninsulin-dependent diabetes mellitus; obesity; variance; weight loss; United Kingdom
- ... The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption causes obesity. We functionally characterized 61 MC4R variants identified in 0.5 million people from UK Biobank and examined their associations with body mass index (BMI) and obesity-related cardiometabolic diseases. We found that the maximal efficacy of β-arrestin recruitment to MC4R, rather than canonical Gαₛ-med ...
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