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- Lourenço Vanzolini, Kenia, et al. Show all 8 Authors
- Talanta 2013 v.116 pp. 647-652
- Alzheimer disease; acetylcholinesterase; bioreactors; central nervous system; chromatography; insecticides; ligands; plant extracts; screening
- ... The use of immobilized capillary enzyme reactors (ICERs) and enzymes coated to magnetic beads ((NT or CT)-MB) for ligand screening has been adopted as a new technique of high throughput screening (HTS). In this work the selected target was the enzyme acetylcholinesterase (AChE), which acts on the central nervous system and is a validated target for the treatment of Alzheimer’s disease, as well as ...
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