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- MAIANTE, A.A., et al. Show all 5 Authors
- Journal of veterinary pharmacology and therapeutics 2009 v.32 no.4 pp. 317-328
- dogs; anesthesia; analgesia; veterinary drugs; general anesthetics; analgesics; methadone; morphine; drug evaluation; megadose; intravenous injection; dose response; pharmacokinetics; cardiovascular system; respiratory system; respiratory physiology; heart rate; cardiac output; respiratory gases
- ... The effects of methadone and morphine were compared in conscious dogs. Six animals received morphine sulfate (1 mg/kg) or methadone hydrochloride (0.5 mg/kg [MET0.5] or 1.0 mg/kg [MET1.0]) intravenously (i.v.) in a randomized complete block design. Cardiopulmonary variables were recorded before (baseline), and for 120 min after drug administration. One outlier was not included in the statistical a ...