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- Maciag, Filip, et al. Show all 4 Authors
- Biochemical and biophysical research communications 2017 v.483 pp. 1194-1205
- calcium; endoplasmic reticulum; extracellular space; genes; genetically modified organisms; homeostasis; membrane potential; mice; mitochondrial membrane; models; neurodegenerative diseases; neurons
- ... Huntington's disease (HD) is a hereditary neurodegenerative disease caused by a polyglutamine expansion within the huntingtin (HTT) gene. One of the cellular functions that is dysregulated in HD is store-operated calcium entry (SOCE), a process in which the depletion of Ca2+ from the endoplasmic reticulum (ER) induces Ca2+ influx from the extracellular space. We detected an enhanced activity of SO ...