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1. The risk of dysphagia is associated with malnutrition and poor functional outcomes in a large population of outpatient older individuals

Author:
Maggio, Marcello,   et al.   ; Tagliaferri, Sara; Lauretani, Fulvio; Pelá, Giovanna; Meschi, Tiziana;     Show all 5 Authors
Source:
Clinical nutrition 2019 v.38 no.6 pp. 2684-2689
ISSN:
0261-5614
Subject:
dysphagia; elderly; exercise test; females; malnutrition; models; nutrition assessment; physical activity; pneumonia; regression analysis; risk factors; screening
Abstract:
... Oropharyngeal dysphagia (OD) is a widespread clinical condition among older adults. Although it represents a risk factor for malnutrition, dehydration and aspiration pneumonia, its assessment and contribution to functional decline is often ignored. The aim of the present study was to estimate the prevalence of OD in a large population of non-institutionalized older people and to evaluate its relat ...
DOI:
10.1016/j.clnu.2018.11.022

2. Impact of Nutritional Status on Caregiver Burden of Elderly Outpatients. A Cross-Sectional Study

Author:
Maggio, Marcello,   et al.   ; Tana, Claudio; Lauretani, Fulvio; Ticinesi, Andrea; Gionti, Luciano; Nouvenne, Antonio; Prati, Beatrice; Meschi, Tiziana;     Show all 8 Authors
Source:
Nutrients 2019 v.11 no.2
ISSN:
2072-6643
Subject:
body mass index; caregivers; cognition; cross-sectional studies; dementia; elderly; exercise test; inventories; multivariate analysis; nutrition assessment; nutritional status; patients; quality of life; walking
Abstract:
... The assistance to older community-dwellers provided by family caregivers is crucial for the maintenance of an acceptable quality of life, especially when dementia is present. The caregiver burden may be extremely high, but few data are available on what patient domains mainly affect the caregiver. The aim of this cross-sectional study, performed in older outpatients, was to examine the impact of c ...
DOI:
10.3390/nu11020281

3. Uric acid within the “normal” range predict 9-year cardiovascular mortality in older individuals. The InCHIANTI study

Author:
Maggio, Marcello,   et al.   ; Brombo, Gloria; Bonetti, Francesco; Volpato, Stefano; Morieri, Mario L.; Napoli, Ettore; Bandinelli, Stefania; Cherubini, Antonio; Guralnik, Jack; Ferrucci, Luigi; Zuliani, Giovanni;     Show all 11 Authors
Source:
Nutrition, metabolism, and cardiovascular diseases 2019 v.29 no.10 pp. 1061-1067
ISSN:
0939-4753
Subject:
acid value; cardiovascular diseases; cohort studies; data analysis; elderly; mortality; multivariate analysis; uric acid
Abstract:
... Increased uric acid levels correlate with cardiovascular disease and cardiovascular/overall mortality. To identify a uric acid threshold above which cardiovascular mortality rises, we studied the relationship between uric acid concentration and overall/cardiovascular mortality.We analyzed data from the InCHIANTI study, a cohort study of Italian community-dwelling people with 9 years of follow-up. ...
DOI:
10.1016/j.numecd.2019.06.018

4. ESPEN guideline on clinical nutrition and hydration in geriatrics

Author:
Maggio, Marcello,   et al.   ; Volkert, Dorothee; Beck, Anne Marie; Cederholm, Tommy; Cruz-Jentoft, Alfonso; Goisser, Sabine; Hooper, Lee; Kiesswetter, Eva; Raynaud-Simon, Agathe; Sieber, Cornel C.; Sobotka, Lubos; van Asselt, Dieneke; Wirth, Rainer; Bischoff, Stephan C.;     Show all 14 Authors
Source:
Clinical nutrition 2019 v.38 no.1 pp. 10-47
ISSN:
0261-5614
Subject:
at-risk population; beverages; clinical nutrition; diet counseling; dietary restriction; dietary supplements; disease course; education; elderly; enteral feeding; exercise; guidelines; malnutrition; nutritional status; obesity; patients; prognosis; quality of life; systematic review; weight loss
Abstract:
... Malnutrition and dehydration are widespread in older people, and obesity is an increasing problem. In clinical practice, it is often unclear which strategies are suitable and effective in counteracting these key health threats.To provide evidence-based recommendations for clinical nutrition and hydration in older persons in order to prevent and/or treat malnutrition and dehydration. Further, to ad ...
DOI:
10.1016/j.clnu.2018.05.024

5. Aging Gut Microbiota at the Cross-Road between Nutrition, Physical Frailty, and Sarcopenia: Is There a Gut–Muscle Axis?

Author:
Maggio, Marcello,   et al.   ; Ticinesi, Andrea; Lauretani, Fulvio; Milani, Christian; Nouvenne, Antonio; Tana, Claudio; Del Rio, Daniele; Ventura, Marco; Meschi, Tiziana;     Show all 9 Authors
Source:
Nutrients 2017 v.9 no.12
ISSN:
2072-6643
Subject:
energy; exercise; inflammation; insulin resistance; intestinal microorganisms; metabolism; muscles; myocytes; nutrients; pathophysiology; patients; prebiotics; probiotics; sarcopenia; skeletal muscle
Abstract:
... Inadequate nutrition and physical inactivity are the mainstays of primary sarcopenia–physiopathology in older individuals. Gut microbiota composition is strongly dependent on both of these elements, and conversely, can also influence the host physiology by modulating systemic inflammation, anabolism, insulin sensitivity, and energy production. The bacterial metabolism of nutrients theoretically in ...
DOI:
10.3390/nu9121303

6. Survival in older adults with dementia and eating problems: To PEG or not to PEG?

Author:
Maggio, Marcello,   et al.   ; Ticinesi, Andrea; Nouvenne, Antonio; Lauretani, Fulvio; Prati, Beatrice; Cerundolo, Nicoletta; Meschi, Tiziana;     Show all 7 Authors
Source:
Clinical nutrition 2016 v.35 pp. 1512-1516
ISSN:
0261-5614
Subject:
caregivers; comorbidity; death; dementia; dysphagia; eating disorders; elderly; enteral feeding; guidelines; hospitals; malnutrition; mortality; nursing homes; patients; regression analysis; risk; Italy
Abstract:
... Despite guidelines, long-term enteral nutrition (EN) through percutaneous endoscopic gastrostomy (PEG) is often prescribed to older individuals with dementia and eating problems (refusal to eat or dysphagia). The aim of this prospective observational non-randomized un-blinded study was to assess the role of this procedure on risk of mortality.184 demented malnourished patients (58 M, age 82.2 ± 7. ...
DOI:
10.1016/j.clnu.2016.04.001

7. Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults – The PROVIDE study

Author:
Maggio, Marcello,   et al.   ; Verlaan, Sjors; Maier, Andrea B.; Bauer, Jürgen M.; Bautmans, Ivan; Brandt, Kirsten; Donini, Lorenzo M.; McMurdo, Marion ET.; Mets, Tony; Seal, Chris; Wijers, Sander LJ.; Sieber, Cornel; Boirie, Yves; Cederholm, Tommy;     Show all 14 Authors
Source:
Clinical nutrition 2017
ISSN:
0261-5614
Subject:
blood serum; elderly; muscles; nutrients; nutritional intervention; protein intake; protein supplements; sarcopenia; skeletal muscle; vitamin D; whey protein
Abstract:
... Inadequate nutritional intake and altered response of aging muscles to anabolic stimuli from nutrients contribute to the development of sarcopenia. Nutritional interventions show inconsistent results in sarcopenic older adults, which might be influenced by their basal nutritional status.To test if baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations and dietary protein intake influenced cha ...
DOI:
10.1016/j.clnu.2017.01.005

8. The association between delirium and sarcopenia in older adult patients admitted to acute geriatrics units: Results from the GLISTEN multicenter observational study

Author:
Maggio, Marcello,   et al.   ; Bellelli, Giuseppe; Zambon, Antonella; Volpato, Stefano; Abete, Pasquale; Bianchi, Lara; Bo, Mario; Cherubini, Antonio; Corica, Francesco; Di Bari, Mauro; Manca, Giovanna Maria; Rizzo, Maria Rosaria; Rossi, Andrea; Landi, Francesco;     Show all 14 Authors
Source:
Clinical nutrition 2017
ISSN:
0261-5614
Subject:
bioelectrical impedance; body mass index; bone density; cognition; confidence interval; demographic statistics; elderly; females; health status; heart failure; observational studies; patients; questionnaires; regression analysis; risk; sarcopenia; skeletal muscle; stroke; variance; walking
Abstract:
... To date, studies assessing the relationship between sarcopenia and delirium, two of the most common geriatric syndromes, are lacking. We sought to explore this association by investigating the co-occurrence of these two conditions and the independent association between them in a population of hospitalized older adults.Cross-sectional multicenter analysis of older adults consecutively admitted to ...
DOI:
10.1016/j.clnu.2017.08.027

9. Nutrition and Inflammation in Older Individuals: Focus on Vitamin D, <em>n</em>-3 Polyunsaturated Fatty Acids and Whey Proteins

Author:
Maggio, Marcello,   et al.   ; Ticinesi, Andrea; Meschi, Tiziana; Lauretani, Fulvio; Felis, Giovanna; Franchi, Fabrizio; Pedrolli, Carlo; Barichella, Michela; Benati, Giuseppe; Di Nuzzo, Sergio; Ceda, Gian Paolo;     Show all 11 Authors
Source:
Nutrients 2016 v.8 no.4
ISSN:
2072-6643
Subject:
C-reactive protein; acute course; anti-inflammatory activity; inflammation; interleukin-1; interleukin-6; nutrients; nutritional intervention; omega-3 fatty acids; polyunsaturated fatty acids; sarcopenia; tumor necrosis factor-alpha; vitamin D; whey; whey protein
Abstract:
... Chronic activation of the inflammatory response, defined as inflammaging, is the key physio-pathological substrate for anabolic resistance, sarcopenia and frailty in older individuals. Nutrients can theoretically modulate this phenomenon. The underlying molecular mechanisms reducing the synthesis of pro-inflammatory mediators have been elucidated, particularly for vitamin D, n-3 polyunsaturated fa ...
DOI:
10.3390/nu8040186

10. Relationship between Carotenoids, Retinol, and Estradiol Levels in Older Women

Author:
Maggio, Marcello,   et al.   ; de Vita, Francesca; Lauretani, Fulvio; Bandinelli, Stefania; Semba, Richard D.; Bartali, Benedetta; Cherubini, Antonio; Cappola, Anne R.; Ceda, Gian Paolo; Ferrucci, Luigi;     Show all 10 Authors
Source:
Nutrients 2015 v.7 no.8 pp. 6506-6519
ISSN:
2072-6643
Subject:
C-reactive protein; alpha-carotene; aromatase; beta-carotene; body mass index; cholesterol; energy; enzyme activity; estradiol; high performance liquid chromatography; insulin; linear models; liver function; lutein; lycopene; neoplasms; postmenopause; radioimmunoassays; testosterone; vitamin A; women; zeaxanthin
Abstract:
... Background. In vitro evidence suggests anti-estrogenic properties for retinol and carotenoids, supporting a chemo-preventive role of these phytochemicals in estrogen-dependent cancers. During aging there are significant reductions in retinol and carotenoid concentrations, whereas estradiol levels decline during menopause and progressively increase from the age of 65. We aimed to investigate the hy ...
DOI:
10.3390/nu7085296

11. IGF-1, the Cross Road of the Nutritional, Inflammatory and Hormonal Pathways to Frailty

Author:
Maggio, Marcello,   et al.   ; De Vita, Francesca; Lauretani, Fulvio; Buttò, Valeria; Bondi, Giuliana; Cattabiani, Chiara; Nouvenne, Antonio; Meschi, Tiziana; Dall'Aglio, Elisabetta; Ceda, Gian Paolo;     Show all 10 Authors
Source:
Nutrients 2013 v.5 no.10 pp. 4184-4205
ISSN:
2072-6643
Subject:
bioactive properties; elderly; inflammation; insulin-like growth factor I; magnesium; minerals; nutrients; nutritional status; oxidative stress; selenium; therapeutics; zinc
Abstract:
... The decline in functional capacity is a heterogeneous phenomenon in the elderly. An accelerated ageing determines a frail status. It results in an increased vulnerability to stressors for decreased physiological reserves. The early identification of a frail status is essential for preventing loss of functional capacity, and its clinical consequences. Frailty and mobility limitation result from an ...
DOI:
10.3390/nu5104184

12. Relationship between use of proton pump inhibitors and IGF system in older subjects

Author:
Maggio, Marcello,   et al.   ; Lauretani, F.; De Vita, F.; Butto, V.; Cattabiani, C.; Masoni, S.; Sutti, E.; Bondi, G.; Dall’Aglio, E.; Bandinelli, S.; Corsonello, A.; Abbatecola, A. M.; Lattanzio, F.; Ferrucci, L.; Ceda, G. P.;     Show all 15 Authors
Source:
The journal of nutrition, health & aging 2014 v.18 no.4 pp. 420-423
ISSN:
1279-7707
Subject:
C-reactive protein; albumins; blood glucose; body mass index; elderly; energy intake; food intake; insulin-like growth factor I; interleukin-6; liver function; men; physical activity; protein intake; proton pump; women
Abstract:
... OBJECTIVES: to investigate the effects of proton pump inhibitors (PPIs) on the insulin-like-growth factor 1(IGF-1) system in the elderly. DESIGN: cross-sectional. SETTING: InCHIANTI study. PARTICIPANTS: 938 older subjects (536 women, 402 men, mean age 75.7±7.4 years). MEASUREMENTS: complete data on age, sex, BMI, liver function, medications, dietary intake, IGF-1, IGF-binding protein-1 and -3 (IGF ...
DOI:
10.1007/s12603-013-0430-z
PubMed:
24676324
PubMed Central:
PMC5077149

13. Glucose and Insulin Measurements from the Oral Glucose Tolerance Test and Mortality Prediction

Author:
Maggio, Marcello,   et al.   ; Metter, E. Jeffrey; Windham, B. Gwen; Simonsick, Eleanor M.; Ling, Shari M.; Egan, Josephine M.; Ferrucci, Luigi;     Show all 7 Authors
Source:
Diabetes care 2008 v.31 no.5 pp. 1026-1030
ISSN:
0149-5992
Subject:
fasting; glucose; glucose tolerance; insulin; longitudinal studies; mortality; prediction; risk factors
Abstract:
... OBJECTIVE:--To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality. RESEARCH DESIGN AND METHODS--A total of 1,401 initially nondiabetic participants from the Baltimore Longitudinal Study of Aging aged 17-95 years underwent one or more OGTTs (median 2, range 1-8), with insulin and glucose measurements taken every 20 min over the course of 2 h included ...
DOI:
10.2337/dc07-2102
PubMed:
18268070
PubMed Central:
PMC2430037