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- Maimon, Roy, et al. Show all 11 Authors
- Cell 2019 v.177 no.2 pp. 272-285.e16
- brain; crystal structure; dimerization; humans; ligands; mice; models; neurons; receptors
- ... Proper brain function requires high-precision neuronal expansion and wiring, processes controlled by the transmembrane Roundabout (Robo) receptor family and their Slit ligands. Despite their great importance, the molecular mechanism by which Robos’ switch from “off” to “on” states remains unclear. Here, we report a 3.6 Å crystal structure of the intact human Robo2 ectodomain (domains D1–8). We dem ...