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1. Development of monoclonal antibodies specific to Marek disease virus-EcoRI-Q (Meq) for the immunohistochemical diagnosis of Marek disease using formalin-fixed, paraffin-embedded samples

Author:
Aoi Kurokawa; Yu Yamamoto
Source:
Journal of veterinary diagnostic investigation 2022 v.34 no.3 pp. 458-464
ISSN:
1943-4936
Subject:
Marek disease,   etc   ; antigens; immune response; immunohistochemistry; lymphoma; pH;     Show all 6 Subjects
Abstract:
... Marek disease (MD) is a viral disease characterized by the development of lymphoma in poultry. Although morphologic confirmation of lymphoma is used to diagnose MD, immunohistochemical detection of MD virus-EcoRI-Q (Meq), which is a viral protein that is expressed exclusively in MD tumor cells, would further improve the accuracy of diagnosis. We developed monoclonal antibodies (mAbs) that specific ...
DOI:
10.1177/10406387221080444

2. Phenotypic characterization of gamma delta (γδ) T cells in chickens infected with or vaccinated against Marek's disease virus

Author:
Ayumi Matsuyama-Kato; Hiroshi Iseki; Nitish Boodhoo; Jegarubee Bavananthasivam; Nadiyah Alqazlan; Mohamed Faizal Abdul-Careem; Brandon L. Plattner; Shahriar Behboudi; Shayan Sharif
Source:
Virology 2022 v.568 pp. 115-125
ISSN:
0042-6822
Subject:
Marek disease,   etc   ; Mardivirus; cytotoxicity; interferons; monitoring; neoplasms; phenotype; vaccination; virology; viruses;     Show all 10 Subjects
Abstract:
... Marek's disease (MD) vaccines reduce the incidence of MD but cannot control virus shedding. To develop new vaccines, it is essential to elucidate mechanisms of immunity to Marek's disease virus (MDV) infection. In this regard, gamma delta (γδ) T cells may play a significant role in prevention of viral spread and tumor surveillance. Here we demonstrated that MDV vaccination induced interferon (IFN) ...
DOI:
10.1016/j.virol.2022.01.012

3. Early Challenge with Oncogenic Marek's Disease Virus Does Not Interfere with Load of Marek's Disease Vaccines DNA in the Feather Pulp at 7 Days of Age

Author:
T. Boyett; R. Thiemann; M. Correa; A. L. Cortes; I. M. Gimeno
Source:
Avian diseases 2022 v.66 no.1 pp. 106-111
ISSN:
0005-2086
Subject:
Marek disease,   etc   ; DNA; Meleagrid alphaherpesvirus 1; feathers; flocks; mixed infection; quantitative polymerase chain reaction; retrospective studies; vaccination; vaccines; viral load; viruses;     Show all 12 Subjects
Abstract:
... In the last decade, monitoring Marek's disease (MD) vaccination by real-time PCR has become a common practice. Evaluating in vivo replication of MD vaccines in the feather pulp (FP) at 7 days of age provides information on how well a flock has been vaccinated. Factors such as vaccine dose, combination with other vaccines, age and route of vaccination, and the origin of the vaccine can influence th ...
DOI:
10.1637/21-00112

4. Molecular detection and phylogenetic analysis of Marek's disease virus virulence‐associated genes from vaccinated flocks in southern India reveals circulation of virulent MDV genotype

Author:
T. R. Kannaki; E. Priyanka; Y. Nishitha; S. Vamshi Krishna; Santosh Haunshi; Madhuri Subbiah
Source:
Transboundary and emerging diseases 2022 v.69 no.4 pp. e244
ISSN:
1865-1674
Subject:
Marek disease,   etc   ; Mardivirus; biosecurity; flocks; histopathology; monitoring; mutation; necropsy; oncogenes; pathotypes; phylogeny; poultry industry; proline; transcriptional activation; vaccination; virulence; Hungary; India;     Show all 18 Subjects
Abstract:
... Marek's disease (MD) is a re‐emerging viral disease of chickens and a serious economic threat to the poultry industry worldwide. Continuous surveillance with molecular investigation is essential to monitor the emergence of virulent Marek's disease virus (MDV) strains and to devise any appropriate vaccination strategy and implement bio‐security programmes. In the present study, we investigated the ...
DOI:
10.1111/tbed.14289

5. Vaccinal Efficacy of recombinant Marek's disease vaccine 301B/1 expressing chicken interleukin-15

Author:
Kim Taejoong Nmn; Hearn Cari J.
Source:
Avian diseases 2022 v.66 no.1 pp. 79-84
ISSN:
0005-2086
Subject:
Marek disease,   etc   ; Meleagrid alphaherpesvirus 1; T-lymphocytes; atrophy; cell proliferation; cell-mediated immunity; chickens; interleukin-15; serotypes; vaccines; virulence; virus replication; viruses;     Show all 13 Subjects
Abstract:
... Marek's disease (MD) vaccine does not provide sterilizing immunity that prevents subsequent MDV replication and shedding in vaccinated birds. It is hypothesized that cell-mediated immunity is critical to control the virus replication in chicken because MDV exists in cell-associated forms in the host. To improve the MD vaccine efficacy, particularly cell-mediated immunity, we constructed recombinan ...
Handle:
10113/7800856
DOI:
10.1637/21-00089

6. MDV-induced differential microRNA expression in the primary lymphoid organ of thymus

Author:
Mohammad Heidari; Huanmin Zhang; Lakshmi Sunkara
Source:
Microbial pathogenesis 2022 v.170 pp. 105688
ISSN:
0882-4010
Subject:
Marek disease,   etc   ; Mardivirus; T-cell lymphoma; apoptosis; atrophy; carcinogenesis; chickens; etiological agents; gene expression; genome; microRNA; paralysis; pathogenicity; sequence homology; transcription (genetics); viruses;     Show all 16 Subjects
Abstract:
... Marek's disease virus (MDV), a highly contagious cell associated virus, is the etiological agent of Marek's disease (MD), a lymphoproliferative and neuropathic disease of domestic chickens. Clinical signs of MD include transient paralysis, bursal/thymic atrophy, and T cell lymphomas. MicroRNAs (miRNAs) are short single-stranded non-coding RNAs that regulate gene expression by transcriptional suppr ...
Handle:
10113/7861848
DOI:
10.1016/j.micpath.2022.105688
CHORUS:
10.1016/j.micpath.2022.105688

7. Effects of early-life cecal microbiota transplantation from divergently selected inbred chicken lines on growth, gut serotonin, and immune parameters in recipient chickens

Author:
Cheng Heng Wei; Yuechi Fu; Jiaying Hu; Marisa A. Erasmus; Timothy A. Johnson; Heng-wei Cheng
Source:
Poultry science 2022 v.101 no.7 pp. 101925
ISSN:
0032-5791
Subject:
Marek disease,   etc   ; antibody formation; body weight; chickens; corticosterone; health status; heterophils; ileum; inflammation; interleukin-10; interleukin-6; intestinal microorganisms; males; oviposition; serotonin; testosterone; villi;     Show all 17 Subjects
Abstract:
... Recent studies have revealed that fecal microbiota transplantation exerts beneficial effects on modulating stress-related inflammation and gastrointestinal health of the host. The aim of this study was to examine if cecal microbiota transplantation (CMT) presents similar efficiency in improving the health status of egg-laying strain chickens. Chicken lines 6₃ and 7₂ divergently selected for resist ...
Handle:
10113/7752384
DOI:
10.1016/j.psj.2022.101925
CHORUS:
10.1016/j.psj.2022.101925

8. Emerging natural recombinant Marek's disease virus between vaccine and virulence strains and their pathogenicity

Author:
Yanping Zhang; Xingge Lan; Yanan Wang; Yumeng Lin; Zhenghao Yu; Rongrong Guo; Kai Li; Hongyu Cui; Xiaole Qi; Yongqiang Wang; Li Gao; Qing Pan; Aijing Liu; Yulong Gao; Xiaomei Wang; Changjun Liu
Source:
Transboundary and emerging diseases 2022 v.69 no.5 pp. e1702
ISSN:
1865-1674
Subject:
Marek disease,   etc   ; Mardivirus; atrophy; chickens; disease diagnosis; genetic variation; genomics; light harvesting complex; mortality; oncogenic viruses; reproduction; risk; skeleton; spleen; vaccines; viral genome; virulence; China;     Show all 18 Subjects
Abstract:
... Marek's disease virus (MDV), an oncogenic virus belonging to the subfamily Alphaherpesvirinae, causes Marek's disease (MD). Vaccines can control MD but cannot block the viral infection; they are considered imperfect vaccines, which carry the risk of recombination. In this study, six natural recombinant MDV strains were isolated from infected chickens in commercial flocks in China. We sequenced and ...
DOI:
10.1111/tbed.14506

9. Research Note: Characterization of S-Meq containing the deletion in Meq protein's transactivation domain in a Marek's disease virus strain in Japan

Author:
Shiro Murata; Eiji Yamamoto; Natsumi Sakashita; Naoya Maekawa; Tomohiro Okagawa; Satoru Konnai; Kazuhiko Ohashi
Source:
Poultry science 2021 v.100 no.11 pp. 101461
ISSN:
0032-5791
Subject:
Marek disease,   etc   ; Japan; Mardivirus; carcinogenesis; lymphoma; oncogene proteins; poultry industry; transcription factors; transcriptional activation; vaccination; virulence;     Show all 11 Subjects
Abstract:
... Marek's disease virus (MDV) causes malignant lymphomas in chickens (Marek's disease; MD). Although MD has caused significant economic losses to the poultry industry, currently, its occurrence in the field is effectively controlled by vaccination. However, the genetic characteristics of MDV strains have changed, and the poultry industry has experienced MD outbreaks in vaccinated chickens because of ...
DOI:
10.1016/j.psj.2021.101461

10. Effects of the In Ovo Vaccination of the ts-11 Strain of Mycoplasma gallisepticum in Layer Embryos and Posthatch Chicks

Author:
Alqhtani Abdulmohsen H.; Fatemi Seyed A.; Elliott Katie Elaine; Branton Scott L.; Evans Jeffrey Dwayne; Leigh Spencer A.; Gerard Patrick D.; Peebles Edgar D.
Source:
Animals 2022 v.12 no. pp. -
ISSN:
2076-2615
Subject:
Marek disease,   etc   ; DNA; Mycoplasma gallisepticum; amnion; body weight; egg weight; eggs; females; males; vaccination; vaccines; weight loss;     Show all 12 Subjects
Abstract:
... The transmission of the ts-11 strain of Mycoplasma gallisepticum (MG) vaccine (ts-11MGV) between incubated eggs and between hatchlings that was administrated via in ovo injection, and its subsequent effects on their posthatch performance were evaluated. Marek's disease diluent alone (sham-injected) or containing either 3.63 × 10(1), 10(2), 10(3), or 10(4) cfu of ts-11MGV was manually in ovo-inject ...
Handle:
10113/7758975
DOI:
10.3390/ani12091120

11. Genetic diversity of MHC-BF/BL region in 21 chicken populations

Author:
Yuan Yiming; Zhang Huanmin; Yi Guoqiang; You Zhen; Zhao Chunfang; Yuan Haixu; Wang Kejun; Li Junying; Yang Ning; Lian Ling
Source:
Frontiers in genetics 2021 v.12 no. pp. 710770
ISSN:
1664-8021
Subject:
Marek disease,   etc   ; Gallus gallus; White Leghorn; chickens; chromosome mapping; chromosomes; databases; disease resistance; genetic variation; immune response; introns; major histocompatibility complex; pseudogenes;     Show all 13 Subjects
Abstract:
... The chicken major histocompatibility complex (MHC) on chromosome 16 is the most polymorphic region across the whole genome, which is also an ideal model system for genetic diversity investigation. The MHC BF/BL region is 92 kb in length with high GC content consisting of 18 genes and 1 pseudogene (Blec4), which plays important roles in immune response. To evaluate polymorphism of the Chinese indig ...
Handle:
10113/7709582
DOI:
10.3389/fgene.2021.710770

12. Virus-encoded miR-155 ortholog in Marek’s disease virus promotes cell proliferation via suppressing apoptosis by targeting tumor suppressor WWOX

Author:
Zhi-Jian Zhu; Man Teng; Hui-Zhen Li; Lu-Ping Zheng; Jin-Ling Liu; Yongxiu Yao; Venugopal Nair; Gai-Ping Zhang; Jun Luo
Source:
Veterinary microbiology 2021 v.252 pp. 108919
ISSN:
0378-1135
Subject:
Marek disease,   etc   ; Human gammaherpesvirus 8; T-cell lymphoma; T-lymphocytes; apoptosis; carcinogenesis; cell proliferation; chick embryos; fibroblasts; immunosuppression; microRNA; poultry; virus replication;     Show all 13 Subjects
Abstract:
... Marek’s disease virus serotype 1 (MDV-1) is an important oncogenic α-herpesvirus that induces immunosuppressive and rapid-onset T-cell lymphomatous disease in poultry commonly referred to as Marek's disease (MD). As an excellent biomodel for the study of virally-induced cancers in natural hosts, MDV-1 encoded microRNAs (miRNAs) have been previously demonstrated with the potential roles to act as c ...
DOI:
10.1016/j.vetmic.2020.108919

13. Comparative Molecular Characterization of Three Gallid alphaherpesvirus Type 3 Strains 301B/1, HPRS24, and SB-1

Author:
Taejoong Kim; Jeremy D. Volkening; Stephen J. Spatz
Source:
Avian diseases 2020 v.64 no.2 pp. 174-182
ISSN:
0005-2086
Subject:
Marek disease,   etc   ; Meleagrid alphaherpesvirus 1; lymphatic diseases; terminal repeat sequences; vaccines; viral genome; virulence;     Show all 7 Subjects
Abstract:
... Marek's disease (MD) is a highly contagious lymphoproliferative disease of chickens caused by Gallid alphaherpesvirus type 2. Gallid alphaherpesvirus type 3 (GaHV-3) strain 301B/1 was previously shown to be an effective MD vaccine with synergistic efficacy when used as a bivalent vaccine with turkey herpesvirus. Since the nucleotide sequences of only two GaHV-3 strains have been determined, we sou ...
DOI:
10.1637/0005-2086-64.2.174

14. Analysis of the evolution and transmission dynamics of the field MDV in China during the years 1995–2020, indicating the emergence of a unique cluster with the molecular characteristics of vv+ MDV that has become endemic in southern China

Author:
Qiaomu Deng; Mengya Shi; Qiuhong Li; Peikun Wang; Min Li; Weiwei Wang; Yanli Gao; Haijuan Li; Lulu Lin; Teng Huang; Ping Wei
Source:
Transboundary and emerging diseases 2021 v.68 no.6 pp. 3574-3587
ISSN:
1865-1674
Subject:
Marek disease,   etc   ; amino acids; chickens; genes; genetic variation; phylogeny; phylogeography; poultry industry; vaccines; virulence; China;     Show all 11 Subjects
Abstract:
... Marek's disease (MD) continues to threaten the sustainability of the world poultry industry. In this study, the sequences of the meq gene of 220 MDV strains isolated during the years 1964–2020 were analysed, including 50 from our group plus 170 isolates from the GenBank. Analyses, using phylogenetic trees, amino acid (aa)‐mutation screening, evolutionary studies and transmission dynamics were all ...
DOI:
10.1111/tbed.13965

15. Pervasive Differential Splicing in Marek’s Disease Virus Can Discriminate CVI-988 Vaccine Strain from RB-1B Very Virulent Strain in Chicken Embryonic Fibroblasts

Author:
Yashar Sadigh; Abdessamad Tahiri-Alaoui; Stephen Spatz; Venugopal Nair; Paolo Ribeca
Source:
Viruses 2020 v.12 no.3 pp. -
ISSN:
1999-4915
Subject:
Marek disease,   etc   ; Mardivirus; RNA; chickens; fibroblasts; pathogenesis; poultry health; sequence homology; transcriptome; vaccines; virulence; virulent strains;     Show all 12 Subjects
Abstract:
... Marek’s disease is a major scourge challenging poultry health worldwide. It is caused by the highly contagious Marek’s disease virus (MDV), an alphaherpesvirus. Here, we showed that, similar to other members of its Herpesviridae family, MDV also presents a complex landscape of splicing events, most of which are uncharacterised and/or not annotated. Quite strikingly, and although the biological rel ...
DOI:
10.3390/v12030329

16. Codon Deoptimization of UL54 in meq-Deleted Marek's Disease Vaccine Candidate Eliminates Lymphoid Atrophy but Reduces Vaccinal Protection

Author:
Steven J. Conrad; Cari J. Hearn; Robert F. Silva; John R. Dunn
Source:
Avian diseases 2020 v.64 no.3 pp. 243-246
ISSN:
0005-2086
Subject:
Marek disease,   etc   ; Gallid alphaherpesvirus 2; atrophy; economic impact; etiological agents; genes; mutants; poultry industry; vaccines; viral genome; viruses;     Show all 11 Subjects
Abstract:
... Marek's disease (MD) is an oncogenic, lymphoproliferative, and highly contagious disease of chickens. Its etiologic agent is the alphaherpesvirus Marek's disease virus (MDV, Gallid alphaherpesvirus 2), and it is a chronic and ubiquitous problem for the poultry industry with significant economic impact in the United States and worldwide. We have previously demonstrated that MDV attenuated by dicodo ...
DOI:
10.1637/aviandiseases-D-19-00166

17. Analysis of DNA methylation of CD79B in MDV-infected chicken spleen

Author:
Lu-lu WANG; Chun-fang ZHAO; Chang-jun LIU; Hao ZHANG; Ling LIAN
Source:
Journal of integrative agriculture 2021 v.20 no.11 pp. 2995-3002
ISSN:
2095-3119
Subject:
Marek disease,   etc   ; B-lymphocytes; DNA methylation; Mardivirus; agriculture; antigens; carcinogenicity; chickens; gene expression; immunosuppression; introns; models; spleen; viruses;     Show all 14 Subjects
Abstract:
... Marek's disease (MD), an immunosuppressive disease induced by Marek's disease virus (MDV), provides an ideal model for studying diseases caused by a carcinogenic virus. CD79B is a B-cell antigen receptor complex-associated protein β-chain precursor which is involved in the activation, proliferation, differentiation of B-cell and the transmission of downstream signals. This study analyzed CD79B gen ...
DOI:
10.1016/S2095-3119(20)63564-X

18. Natural co-infection with two virulent wild strains of Marek’s disease virus in a commercial layer flock

Author:
Zhenghao Yu; Yanping Zhang; Xingge Lan; Yanan Wang; Feng Zhang; Yulong Gao; Kai Li; Li Gao; Qing Pan; Xiaole Qi; Hongyu Cui; Linyi Zhou; Guorong Sun; Xiaomei Wang; Changjun Liu
Source:
Veterinary microbiology 2020 v.240 pp. 108501
ISSN:
0378-1135
Subject:
Marek disease,   etc   ; Mardivirus; chickens; flocks; genes; mixed infection; mutation; phylogeny; polymerase chain reaction; sequence alignment; viral load; virulence; virulent strains;     Show all 13 Subjects
Abstract:
... Marek’s disease (MD) is a highly contagious lymphoproliferative poultry disease caused by the oncogenic herpesvirus, Marek’s disease virus (MDV). MDV strains have shown a continued evolution of virulence leading to immune failure, and MD cases continue to occur. Co-infection of virulent MDV strains is an important factor leading to viral evolution and host immune failure. This study conducted a la ...
DOI:
10.1016/j.vetmic.2019.108501

19. A comparison of exosome purification methods using serum of Marek's disease virus (MDV)-vaccinated and -tumor-bearing chickens

Author:
Sabari Nath Neerukonda; Nicholas A. Egan; Joseph Patria; Imane Assakhi; Phaedra Tavlarides-Hontz; Shannon Modla; Eric R. Muñoz; Matthew B. Hudson; Mark S. Parcells
Source:
Heliyon 2020 v.6 no.12 pp. e05669
ISSN:
2405-8440
Subject:
Marek disease,   etc   ; Mardivirus; T-cell lymphoma; biomarkers; blood serum; chickens; exosomes; immunosuppression; live vaccines; microRNA; paralysis; polyethylene glycol; poultry production;     Show all 13 Subjects
Abstract:
... Marek's disease (MD) is an alphaherpesvirus (Marek's disease virus, MDV)-induced pathology of chickens associated with paralysis, immunosuppression, neurological signs, and T-cell lymphomas. MD is controlled in poultry production via live attenuated vaccines. The purpose of the current study was to compare methods for precipitating exosomes from vaccinated and protected chicken sera (VEX) and tumo ...
DOI:
10.1016/j.heliyon.2020.e05669

20. Reemergence of reticuloendotheliosis virus and Marek's disease virus co-infection in Yellow-Chickens in Southern China

Author:
Min Li; Peikun Wang; Qiuhong Li; Qiaomu Deng; Mengya Shi; Meilan Mo; Tianchao Wei; Teng Huang; Ping Wei
Source:
Poultry science 2021 v.100 no.8 pp. 101099
ISSN:
0032-5791
Subject:
Marek disease,   etc   ; Mardivirus; Reticuloendotheliosis virus; amino acids; genes; histopathology; mixed infection; morbidity; mortality; poultry; poultry industry; reticuloendotheliosis; sequence homology; China;     Show all 14 Subjects
Abstract:
... The reticuloendotheliosis virus (REV) and the Marek's disease virus (MDV) cause reticuloendotheliosis (RE) and Marek's disease (MD) in poultry, respectively. According to epidemiological results obtained in our laboratory from 2010 to 2017, the positive rates of REV and MDV co-infection remained at low levels. In the present study, during the period of October 2018 to July 2020, 4 clinical cases w ...
DOI:
10.1016/j.psj.2021.101099