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- Martins, Nathan Dias, et al. Show all 6 Authors
- Ecotoxicology and environmental safety 2019 v.173 pp. 436-443
- Hoplias malabaricus; antioxidant activity; biomarkers; cardiorespiratory fitness; catalase; enzyme activity; freshwater fish; gills; glutathione; glutathione peroxidase; glutathione transferase; heart rate; intraperitoneal injection; lipid peroxidation; liver; microcystin-LR; oxidation; oxidative stress; oxygen; protein content; proteins; superoxide dismutase; tidal volume; toxicity
- ... This study investigated the effect of microcystin-LR (MC-LR) on in vivo cardiorespiratory function and on tissue biomarkers of oxidative stress in gills and liver of the trahira, a neotropical freshwater fish. Trahira were treated with an intraperitoneal injection of 100 µg MC-LR.kg−1 body mass or a saline, with the toxic effects of MC-LR then evaluated after 48 h. Rates of oxygen uptake (V̇O2) di ...
- Martins, Nathan Dias, et al. Show all 5 Authors
- Toxicon 2017
- Brycon amazonicus; Cyanobacteria; antioxidant activity; antioxidants; cell death; cytoskeleton; fish; gills; humans; liver; microcystin-LR; oxidation; oxidative stress; superoxide dismutase; surface water; toxicity
- ... Microcystin's (MCs) are toxins produced by several groups of cyanobacteria, in water bodies throughout the world, in a process which is being intensified by human action. Among the variants of MCs, MC-LR stands out for its distribution and toxicity. MCs are potent inhibitors of protein phosphatases 1 and 2 A, which causes disruption of the cytoskeleton and consequent cell death. They can also alte ...
- Martins, Nathan Dias, et al. Show all 4 Authors
- Chemosphere 2011 v.84 no.1 pp. 154-159
- Oreochromis niloticus; fish; gills; heart rate; hypoxia; intraperitoneal injection; microcystin-LR; tidal volume
- ... The effects of microcystin on the cardio-respiratory function of Nile tilapia were analyzed 48h after intraperitoneal injection of microcystin-LR (MC-LR – 100μgkg⁻¹body weight). Exposure to MC-LR induced significant reduction in metabolic rate (V˙O₂) and increase in the critical O₂ tension (PCO₂) in relation to the control group. Gill ventilation (V˙G) and ventilatory tidal volume (VT) were consid ...