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1. Deriving information from complex data sets: Impact of forage on fatty acids in cow milk

Author:
Matthew J. Picklo,   et al.   ; James Harnly; Kenneth F. Kalscheur; Andrew Magnuson; Michael R. Bukowski; Naomi K. Fukagawa; John W. Finley;     Show all 7 Authors
Source:
Journal of food composition and analysis 2022 v.107 pp. 104179
ISSN:
0889-1575
Subject:
cows; data collection; fatty acid composition; forage; milk; milk fatty acids; multivariate analysis; variance
Abstract:
... Machine learning and classical statistics were used to unravel the complex data set generated by the analysis of 77 fatty acids in milk from 76 cows fed 3 forages. Multivariate analysis of variance – principal components analysis (mANOVA-PCA) was used to deconvolute the data and determine the variance contributed by the main experimental factors: forage, the arbitrary cow groups, cow-to-cow variab ...
DOI:
10.1016/j.jfca.2021.104179
CHORUS:
10.1016/j.jfca.2021.104179

2. Simple, Rapid Lipidomic Analysis of Triacylglycerols in Bovine Milk by Infusion‐Electrospray Mass Spectrometry

Author:
Matthew J. Picklo,   et al.   ; Michael R. Bukowski;     Show all 2 Author
Source:
Lipids 2021 v.56 no.2 pp. 243-255
ISSN:
0024-4201
Subject:
carbon; lipidomics; mass spectrometry; milk; phospholipids; rapid methods; solid phase extraction; triacylglycerols
Abstract:
... Bovine milk is a complex mixture of lipids, proteins, carbohydrates, and other factors of which lipids comprise 3–5% of the total mass. Rapid analysis and characterization of the triacylglycerols (TAG) that comprise about 95% of the total lipid is daunting given the numerous TAG species. In the attached methods paper, we demonstrate an improved method for identifying and quantifying TAG species by ...
DOI:
10.1002/lipd.12292

3. Hepatic Fatty Acid and Transcriptome Profiles during the Transition from Vegetable‐ to Fish Oil‐Based Diets in Rainbow Trout (Oncorhynchus mykiss)

Author:
Matthew J. Picklo,   et al.   ; Beth M. Cleveland; Guangtu Gao; Lisa M. Radler;     Show all 4 Authors
Source:
Lipids 2021 v.56 no.2 pp. 189-200
ISSN:
0024-4201
Subject:
Oncorhynchus mykiss; acyl coenzyme A; cholesterol; diet; extracellular matrix; fatty acid composition; feed deprivation; finishing; fish feeding; fish feeds; fish oils; gene expression regulation; homeostasis; lipid metabolism; liver; long chain unsaturated fatty acids; omega-3 fatty acids; redox reactions; transcriptome; transcriptomics; trout; vegetable oil
Abstract:
... A finishing diet strategy is effective at increasing fillet long‐chain n‐3 fatty acid content in fish consuming sustainable plant oil‐based diets. This study investigates the outcomes of a fish oil finishing diet upon the hepatic fatty acid and transcriptome profile in rainbow trout (Oncorhynchus mykiss). Fish were placed on one of three feeding treatments: (1) FO: a fish oil (FO) diet for 20 week ...
Handle:
10113/7175943
DOI:
10.1002/lipd.12287

4. Metabolomes of Lewis lung carcinoma metastases and normal lung tissue from mice fed different diets

Author:
Matthew J. Picklo,   et al.   ; Lin Yan; Sneha Sundaram; Bret M. Rust; Michael R. Bukowski;     Show all 5 Authors
Source:
Journal of nutritional biochemistry 2022 v.107 pp. 109051
ISSN:
0955-2863
Subject:
arachidonic acid; cholesterol; dietary fat; energy metabolism; fatty acid composition; gas chromatography; glutamine; high fat diet; linoleic acid; lipid metabolism; lung neoplasms; lungs; males; mass spectrometry; metabolites; metabolome; metabolomics; metastasis; models; sorbitol
Abstract:
... Metastasis is a devastating aspect of cancer. This study tested the hypothesis that metabolome of metastases differs from that of host organs by using the spontaneous metastasis model of Lewis lung carcinoma (LLC). In a 2 × 2 design, male C57BL/6 mice with or without a subcutaneous LLC inoculation were fed the standard AIN93G diet or a high-fat diet (HFD) for 12 weeks. Lung metastases from injecte ...
Handle:
10113/7781758
DOI:
10.1016/j.jnutbio.2022.109051

5. Dietary Fat Chain Length, Saturation, and PUFA Source Acutely Affect Diet-Induced Thermogenesis but Not Satiety in Adults in a Randomized, Crossover Trial

Author:
Matthew J. Picklo,   et al.   ; Bret M. Rust; Susan K. Raatz; Shanon L. Casperson; Sara E. Duke;     Show all 5 Authors
Source:
Nutrients 2021 v.13 no.8 pp. -
ISSN:
2072-6643
Subject:
adults; blood serum; cream; cross-over studies; dietary fat; fish oils; ghrelin; glucose; insulin; linseed oil; lipid metabolism; liquids; obesity; olive oil; oxidation; satiety; sunflower oil; thermic effect of food; triacylglycerols
Abstract:
... Structural differences in dietary fatty acids modify their rate of oxidation and effect on satiety, endpoints that may influence the development of obesity. This study tests the hypothesis that meals containing fat sources with elevated unsaturated fats will result in greater postprandial energy expenditure, fat oxidation, and satiety than meals containing fats with greater saturation. In a random ...
DOI:
10.3390/nu13082615

6. Increasing Dietary Fish Oil Reduces Adiposity and Mitigates Bone Deterioration in Growing C57BL/6 Mice Fed a High-Fat Diet

Author:
Matthew J. Picklo,   et al.   ; Jay J. Cao; Brian R. Gregoire; Kim G. Michelsen;     Show all 4 Authors
Source:
Journal of Nutrition 2020 v.150 no.1 pp. 99-107
ISSN:
0022-3166
Subject:
acid phosphatase; adipose tissue; adiposity; alkaline phosphatase; blood serum; bone density; bone resorption; energy; femur; fish oils; high fat diet; inflammation; leptin; males; obesity; omega-3 fatty acids; omega-6 fatty acids; osteocalcin
Abstract:
... Background: Intake of total fat is linked to obesity and inversely associated with bone density in humans. Epidemiologic and animal studies show that long-chain n-3 (ω-3) PUFAs supplied as fish oil (FO) are beneficial to skeletal health. Objective: This study tested the hypothesis that increasing dietary FO would decrease adiposity and improve bone-related outcomes in growing obese mice. Methods: ...
Handle:
10113/7368049
DOI:
10.1093/jn/nxz215
CHORUS:
10.1093/jn/nxz215

7. Simplified Mass Spectrometric Analysis of Ceramides using a Common Collision Energy

Author:
Matthew J. Picklo,   et al.   ; Benjamin K. Hanson; Michael R. Bukowski;     Show all 3 Authors
Source:
Lipids 2019 v.54 no.8 pp. 471-477
ISSN:
0024-4201
Subject:
ceramides; energy; fatty acids; information processing; insulin resistance; ionization; mass spectrometry; neoplasms; neurodegenerative diseases
Abstract:
... Ceramides (CER) are biologically active sphingolipid precursors that are mechanistically linked to several pathogenic states including cancer, insulin resistance, and neurodegeneration. CER are commonly quantified through mass spectrometry‐based methods founded upon a product ion scan (PIS) in positive mode to produce a characteristic m/z 264 ion. The ionization efficiency (IE) of CER species decr ...
Handle:
10113/6606399
DOI:
10.1002/lipd.12179
CHORUS:
10.1002/lipd.12179

8. Impact of beef consumption on saturated fat intake in the United States adult population: Insights from modeling the influences of bovine genetics and nutrition

Author:
Matthew J. Picklo,   et al.   ; Shanon L. Casperson; Zach Conrad; Susan K. Raatz; Justin Derner; James N. Roemmich; Lisa Jahns;     Show all 7 Authors
Source:
Meat science 2020 v.169 pp. 108225
ISSN:
0309-1740
Subject:
Angus; Wagyu; adults; beef; beef consumption; cattle; fat intake; fatty acid composition; genetics; linseed; meat science; models; pastures; saturated fats; tallow
Abstract:
... We sought to determine the impact of breed and finishing ration that reduces the saturated fat (SFA) content of beef on SFA intake (%E) in adults. Using National Health and Nutrition Examination Surveys (2001–2016), we replaced the current fatty acid profile of beef with that from two breeds (Angus, Wagyu) and three finishing rations (pasture, 15% flaxseed supplementation, 35% wet distiller's grai ...
DOI:
10.1016/j.meatsci.2020.108225
CHORUS:
10.1016/j.meatsci.2020.108225

9. Time-restricted feeding mice a high-fat diet induces a unique lipidomic profile

Author:
Matthew J. Picklo,   et al.   ; Aaron A. Mehus; Bret Rust; Joseph P. Idso; Benjamin Hanson; Huawei Zeng; Lin Yan; Michael R. Bukowski;     Show all 8 Authors
Source:
Journal of nutritional biochemistry 2021 v.88 pp. 108531
ISSN:
0955-2863
Subject:
adipose tissue; adiposity; adults; fatty acid composition; fatty liver; genes; high fat diet; insulin resistance; lipid metabolism; lipidomics; liver; males; obesity; phosphatidylcholines; phosphatidylethanolamines; protein synthesis; saturated fatty acids; triacylglycerols
Abstract:
... Time-restricted feeding (TRF) can reduce adiposity and lessen the co-morbidities of obesity. Mice consuming obesogenic high-fat (HF) diets develop insulin resistance and hepatic steatosis, but have elevated indices of long-chain polyunsaturated fatty acids (LCPUFA) that may be beneficial. While TRF impacts lipid metabolism, scant data exist regarding the impact of TRF upon lipidomic composition of ...
DOI:
10.1016/j.jnutbio.2020.108531
CHORUS:
10.1016/j.jnutbio.2020.108531

10. Supplementing rainbow trout (Oncorhynchus mykiss) broodstock diets with choline and methionine improves growth in offspring

Author:
Matthew J. Picklo,   et al.   ; Beth M. Cleveland; Timothy D. Leeds; Carley Brentesen; Jason Frost; Peggy R. Biga;     Show all 6 Authors
Source:
Journal of the World Aquaculture Society 2020 v.51 no.1 pp. 266-281
ISSN:
0893-8849
Subject:
Oncorhynchus mykiss; body condition; body weight; breeding stock; choline; eggs; experimental diets; feeding methods; growth performance; methionine; progeny; spawning
Abstract:
... Nutritional programming represents the mechanism through which broodstock feeding strategies have lifelong effects on the offspring generation. The objective of this study was to determine whether supplementing rainbow trout, Oncorhynchus mykiss broodstock diets with choline and methionine affects offspring growth performance. Experimental diets were produced by top‐dressing a commercial broodstoc ...
DOI:
10.1111/jwas.12634

11. Deposition and mobilization of lipids varies across the rainbow trout fillet during feed deprivation and transition from plant to fish oil-based diets

Author:
Matthew J. Picklo,   et al.   ; Beth M. Cleveland; Susan Raatz; Benjamin K. Hanson; Angelie Wickramaratne;     Show all 5 Authors
Source:
Aquaculture 2018 v.491 pp. 39-49
ISSN:
0044-8486
Subject:
Oncorhynchus mykiss; aquaculture feeds; biochemical pathways; economics; fatty acid composition; feed deprivation; finishing; fish; fish consumption; fish fillets; fish oils; gene expression; lipid metabolism; muscles; muscular atrophy; omega-3 fatty acids; triploidy; vegetable oil
Abstract:
... Identifying aquaculture feeding strategies that reduce the consumption of fish oil without sacrificing the cardioprotective lipid profile of the salmonid fillet will improve aquafeed economics and sustainability. Transitioning fish from a plant oil-based diet to a finishing diet rich in fish oil and long chain n-3 fatty acids (LCn3) for several weeks prior to harvest is effective at boosting the f ...
DOI:
10.1016/j.aquaculture.2018.03.012

12. A High-Fat, High-Oleic Diet, But Not a High-Fat, Saturated Diet, Reduces Hepatic α-Linolenic Acid and Eicosapentaenoic Acid Content in Mice

Author:
Matthew J. Picklo,   et al.   ; Eric J. Murphy;     Show all 2 Author
Source:
Lipids 2016 v.51 no.5 pp. 537-547
ISSN:
0024-4201
Subject:
alpha-linolenic acid; diet; docosahexaenoic acid; docosapentaenoic acid; eicosapentaenoic acid; energy; esterification; linoleic acid; metabolism; mice; oleic acid; omega-3 fatty acids; phospholipids; saturated fatty acids
Abstract:
... Considerable research has focused upon the role of linoleic acid (LNA; 18:2n-6) as a competitive inhibitor of α-linolenic (ALA; 18:3n-3) metabolism; however, little data exist as to the impact of saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) on ALA metabolism. We tested the hypothesis that a high SFA diet, compared to a high MUFA (oleic acid 18:1n-9) diet, reduces ALA conversi ...
DOI:
10.1007/s11745-015-4106-9
CHORUS:
10.1007/s11745-015-4106-9
Chorus Open Access:
10.1007/s11745-015-4106-9

13. Brain and Hepatic Mt mRNA Is Reduced in Response to Mild Energy Restriction and n-3 Polyunsaturated Fatty Acid Deficiency in Juvenile Rats

Author:
Matthew J. Picklo Sr,   et al.   ; Aaron A. Mehus;     Show all 2 Author
Source:
Nutrients 2017 v.9 no.10 pp. -
ISSN:
2072-6643
Subject:
alpha-linolenic acid; cerebellum; cerebral cortex; corn oil; corticosterone; glucocorticoid receptors; juveniles; liver; low calorie diet; malnutrition; messenger RNA; nutrient deficiencies; omega-3 fatty acids; rats; soybean oil; tissues; triiodothyronine
Abstract:
... Metallothioneins (MTs) perform important regulatory and cytoprotective functions in tissues including the brain. While it is known that energy restriction (ER) and dietary n-3 polyunsaturated fatty acid (PUFA) deficiency impact postnatal brain growth and development, little data exist regarding the impact of undernutrition upon MT expression in growing animals. We tested the hypothesis that ER wit ...
Handle:
10113/6472331
DOI:
10.3390/nu9101145
PubMed:
29048374
PubMed Central:
PMC5691761

14. Next-Generation Sequencing Identifies Polyunsaturated Fatty Acid Responsive Genes in the Juvenile Rat Cerebellum

Author:
Matthew J. Picklo,   et al.   ; Aaron A. Mehus; Aaron M. Dickey; Timothy P. L. Smith; Kathleen M. Yeater;     Show all 5 Authors
Source:
Nutrients 2019 v.11 no.2 pp. -
ISSN:
2072-6643
Subject:
alpha-linolenic acid; arachidonic acid; cerebellum; children; corn oil; diet; docosahexaenoic acid; docosapentaenoic acid; energy; gene expression regulation; genes; high-throughput nucleotide sequencing; juveniles; learning; males; messenger RNA; neuroprotective effect; omega-3 fatty acids; rats; soybean oil; transactivators; transcriptome; weaning
Abstract:
... Dietary n-3 polyunsaturated fatty acids (PUFA) influence postnatal brain growth and development. However, little data exist regarding the impacts of dietary n-3 PUFA in juvenile animals post weaning, which is a time of rapid growth. We tested the hypothesis that depleting dietary n-3 PUFA would result in modifications to the cerebellar transcriptome of juvenile rats. To test this hypothesis, three ...
DOI:
10.3390/nu11020407
PubMed:
30769946
PubMed Central:
PMC6412889

15. Relationship of the Reported Intakes of Fat and Fatty Acids to Body Weight in US Adults

Author:
Matthew J Picklo,   et al.   ; Susan K Raatz; Zach Conrad; LuAnn K Johnson; Lisa Jahns;     Show all 5 Authors
Source:
Nutrients 2017 v.9 no.5 pp. -
ISSN:
2072-6643
Subject:
Blacks; Mexican Americans; National Health and Nutrition Examination Survey; adults; body mass index; body weight; carbohydrate intake; dietary fat; dodecanoic acid; educational status; energy expenditure; energy intake; fat intake; fatty acid composition; food intake; linoleic acid; long chain saturated fatty acids; monounsaturated fatty acids; polyunsaturated fatty acids; protein intake; saturated fats; secondary education; sociodemographic characteristics; United States
Abstract:
... Dietary fat composition may modulate energy expenditure and body weight. Little is known about the relationship between fatty acid intake and body weight at a population level. The purposes of this study were to compare intakes of energy, macronutrients, and individual fatty acids across BMI categories (1) for the US adult population and, (2) by sociodemographic groups. Reported dietary intake dat ...
Handle:
10113/5695446
DOI:
10.3390/nu9050438
PubMed:
28452961
PubMed Central:
PMC5452168
CHORUS:
10.3390/nu9050438

16. Modeled replacement of traditional soybean and canola oil with high-oleic varieties increases monounsaturated fatty acid and reduces both saturated fatty acid and polyunsaturated fatty acid intake in the US adult population

Author:
Matthew J Picklo,   et al.   ; Susan K Raatz; Zach Conrad; Lisa Jahns; Martha A Belury;     Show all 5 Authors
Source:
American journal of clinical nutrition 2018 v.108 no.3 pp. 594-602
ISSN:
1938-3207
Subject:
Adequate Intakes; Dietary Reference Intakes; GRAS substances; National Health and Nutrition Examination Survey; adults; alpha-linolenic acid; at-risk population; canola oil; food production; health effects assessments; linoleic acid; oleic acid; saturated fatty acids; soybean oil; soybeans; trans fatty acids; United States
Abstract:
... High-oleic (HO) seed oils are being introduced as replacements for trans fatty acid (TFA)–containing fats and oils. Negative health effects associated with TFAs led to their removal from the US Generally Recognized As Safe list. HO oils formulated for use in food production may result in changes in fatty acid intake at population levels. The purposes of this study were to 1) identify major food so ...
Handle:
10113/6725497
DOI:
10.1093/ajcn/nqy127
CHORUS:
10.1093/ajcn/nqy127

17. Quantitation of protein-S-glutathionylation by LC-MS/MS: Correction for contaminating glutathione and glutathione disulfide

Author:
Matthew J. Picklo,   et al.   ; Michael R. Bukowski; Christopher Bucklin;     Show all 3 Authors
Source:
Analytical Biochemistry 2015 v.469 pp. 54-64
ISSN:
0003-2697
Subject:
chemical reduction; glutathione; ions; liquid chromatography; liver; mass spectrometry; post-translational modification; proteins; rats
Abstract:
... Protein S-glutathionylation is a posttranslational modification that links oxidative stimuli to reversible changes in cellular function. Protein–glutathione mixed disulfide (PSSG) is commonly quantified by reduction of the disulfide and detection of the resultant glutathione species. This methodology is susceptible to contamination by free unreacted cellular glutathione (GSH) species, which are pr ...
Handle:
10113/59914
DOI:
10.1016/j.ab.2014.10.002

18. Fatty acid partitioning varies across fillet regions during sexual maturation in female rainbow trout (Oncorhynchus mykiss)

Author:
Matthew J. Picklo,   et al.   ; Beth M. Cleveland; Gregory M. Weber; Susan K. Raatz; Caird E. Rexroad;     Show all 5 Authors
Source:
Aquaculture 2017 v.475 no. pp. 52-60
ISSN:
0044-8486
Subject:
Oncorhynchus mykiss; chromosomes; diploidy; energy; fatty acids; females; fillet quality; fish; fish fillets; gonads; muscles; nutrient retention; rearing; sexual maturity; triploidy
Abstract:
... Rainbow trout (Oncorhynchus mykiss) are commonly reared as diploids (2N, two sets of chromosomes) or triploids (3N, three sets of chromosomes). Sexual maturation in 2N has negative effects on production efficiency, nutrient retention, and fillet quality. On the other hand, 3N female rainbow trout fail to develop gonads, thus enabling an efficient extended growth period when production of larger fi ...
DOI:
10.1016/j.aquaculture.2017.03.012
CHORUS:
10.1016/j.aquaculture.2017.03.012
Chorus Open Access:
10.1016/j.aquaculture.2017.03.012

19. Consumption of honey, sucrose, and high fructose corn syrup produces similar metabolic effects in glucose-tolerant and -intolerant individuals

Author:
Matthew J. Picklo,   et al.   ; Susan K. Raatz; LuAnn K. Johnson;     Show all 3 Authors
Source:
journal of nutrition 2015 v.145 no.10 pp. 2265-2272
ISSN:
0022-3166
Subject:
C-reactive protein; blood glucose; blood pressure; blood serum; body mass index; body weight; cross-over studies; fasting; fructose; glucose; glucose tolerance; high density lipoprotein cholesterol; high fructose corn syrup; homeostasis; honey; inflammation; insulin; insulin resistance; interleukin-6; lipid metabolism; long term effects; low density lipoprotein cholesterol; sucrose; sweeteners; triacylglycerols
Abstract:
... Background: Public health recommendations call for a reduction in added sugars; however, controversy exists over whether all nutritive sweeteners produce similar metabolic effects. Objective: The objective was to compare the effects of the chronic consumption of 3 nutritive sweeteners [honey, sucrose, and high-fructose corn syrup containing 55% fructose (HFCS55)] on circulating glucose, insulin, l ...
Handle:
10113/61623
DOI:
10.3945/jn.115.218016
CHORUS:
10.3945/jn.115.218016

20. Twice weekly intake of farmed Atlantic salmon (Salmo salar) positively influences lipoprotein concentration and particle size in overweight men and women

Author:
Matthew J. Picklo,   et al.   ; Susan K. Raatz; LuAnn K. Johnson; Thad A. Rosenberger;     Show all 4 Authors
Source:
Nutrition research 2016 pp. -
ISSN:
0271-5317
Subject:
Dietary Guidelines; Salmo salar; adults; blood lipids; blood serum; clinical trials; dose response; fish consumption; lipid content; low density lipoprotein; men; nuclear magnetic resonance spectroscopy; omega-3 fatty acids; overweight; particle size; risk reduction; salmon; women; United States
Abstract:
... The U.S. Dietary Guidelines for Americans recommend twice weekly fish intake. Farmed Atlantic salmon is a good source of omega-3 (n-3) fatty acids which have positive lipid modifying effects; however, it is unknown whether these responses are dose-dependent. Our primary research objective was to determine the effect of dose- dependent intake of farmed Atlantic salmon on lipoprotein particle (P) si ...
DOI:
10.1016/j.nutres.2016.06.011
CHORUS:
10.1016/j.nutres.2016.06.011