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- McCollum, Isabelle, et al. Show all 6 Authors
- Toxicon 2015 v.108 pp. 11-14
- Cicuta; gamma-aminobutyric acid receptors; plant extracts; poisonous plants; polyacetylenes; toxicity; tubers
- ... Water hemlocks (Cicuta spp.) are acutely toxic members of the Umbellierae family; the toxicity is due to the presence of C17-polyacetylenes such as cicutoxin. There is only limited evidence of noncompetitive antagonism by C17-polyacetylenes at GABAA receptors. In this work with WSS-1 cells, we documented the noncompetitive blockade of GABAA receptors by an aqueous extract of water hemlock (Cicuta ...