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1. Differences in chemical composition predictive of in vitro biological activity among commercially important cultivars of genus Camellia

Author:
McGinley, John N.,   et al.   ; Wang, Yijun; Kan, Zhipeng; Wan, Xiaochun; Thompson, Henry J.;     Show all 5 Authors
Source:
Food chemistry 2019
ISSN:
0308-8146
Subject:
Camellia; bioactive compounds; bioactive properties; catechin; cell growth; cultivars; epigallocatechin gallate; high performance liquid chromatography; leaves; metabolome; tandem mass spectrometry; tea
Abstract:
... Leaves of plants from the genus Camellia (CAM) are used to make tea; however, there are limited data that compares chemical composition and biological activity of CAM cultivars used to make six tea types. Fourteen CAM cultivars were analyzed by HPLC and UPLC-Q-TOF-MS/MS and biological activity was assessed in a cell growth assay. Tea bioactives and cell growth inhibition varied 2-4 fold. EGCG was ...
DOI:
10.1016/j.foodchem.2019.06.017

2. Differences in Chemical Composition among Commercially Important Cultivars of Genus Camellia

Author:
McGinley, John N.,   et al.   ; Wang, Yijun; Kan, Zhipeng; Wang, Dongxu; Zhang, Liang; Wan, Xiaochun; Thompson, Henry J.;     Show all 7 Authors
Source:
Journal of agricultural and food chemistry 2018 v.67 no.19 pp. 5457-5464
ISSN:
1520-5118
Subject:
Camellia; alkaloids; amino acids; beverages; biochemical pathways; biomarkers; chemical composition; cultivars; flavanols; flavones; functional foods; glycosides; leaves; phenolic acids; plasticity; prebiotics; processing technology; tandem mass spectrometry; tea; ultra-performance liquid chromatography
Abstract:
... Leaves from plants of the genus Camellia are used to make beverages and food products; however, there is limited data that compares the chemical composition of the unprocessed leaves of cultivars traditionally used to make these products. Plucked, fresh leaves from 14 commercially important cultivars were analyzed by ultra-performance liquid chromatography–quadrupole time-of-flight tandem mass spe ...
DOI:
10.1021/acs.jafc.8b06164

3. Beneficial Effects of Common Bean on Adiposity and Lipid Metabolism

Author:
McGinley, John N.,   et al.   ; Thompson, Henry J.; Neil, Elizabeth S.; Brick, Mark A.;     Show all 4 Authors
Source:
Nutrients 2017 v.9 no.9
ISSN:
2072-6643
Subject:
Phaseolus vulgaris; adipocytes; adiposity; beans; beta oxidation; bioactive properties; carnitine palmitoyltransferase; developed countries; genetic models; liver; long chain fatty acids; meta-analysis; morphometry; obesity; oxidation; pandemic; powders; protein synthesis; randomized clinical trials; rats; systematic review; triacylglycerols; weight control
Abstract:
... In developed countries which are at the epicenter of the obesity pandemic, pulse crop consumption is well below recommended levels. In a recent systematic review and meta-analysis of 21 randomized controlled clinical trials, pulse consumption was associated with improved weight control and reduced adiposity, although the underlying mechanisms were a matter of speculation. Common bean (Phaseolus vu ...
DOI:
10.3390/nu9090998

4. Premenopausal Obesity and Breast Cancer Growth Rates in a Rodent Model

Author:
McGinley, John N.,   et al.   ; Matthews, Shawna B.; Neil, Elizabeth S.; Thompson, Henry J.;     Show all 4 Authors
Source:
Nutrients 2016 v.8 no.4
ISSN:
2072-6643
Subject:
animal models; apoptosis; breast neoplasms; carcinoma; cell cycle; lifestyle; neoplasm cells; obesity; premenopause; prognosis; protein synthesis; rats; women
Abstract:
... Obese premenopausal women with breast cancer have poorer prognosis for long term survival, in part because their tumors are larger at the time of diagnosis than are found in normal weight women. Whether larger tumor mass is due to obesity-related barriers to detection or to effects on tumor biology is not known. This study used polygenic models for obesity and breast cancer to deconstruct this que ...
DOI:
10.3390/nu8040214

5. Effect of low or high glycemic load diets on experimentally induced mammary carcinogenesis in rats

Author:
McGinley, John N.,   et al.   ; Thompson, Henry J.; Neuhouser, Marian L.; Lampe, Johanna W.; Neil, Elizabeth S.; Schwartz, Yvonne; McTiernan, Anne;     Show all 7 Authors
Source:
Molecular nutrition & food research 2016 v.60 no.6 pp. 1416-1426
ISSN:
1613-4125
Subject:
animal models; breast neoplasms; carcinogenesis; cell growth; dietary carbohydrate; eating habits; glycemic effect; glycemic index; humans; protective effect; rats; resistant starch; risk
Abstract:
... SCOPE: High glycemic load diets have been associated with increased breast cancer risk in population‐based studies, but the evidence is mixed. This investigation determined whether diets differing in glycemic load affected the carcinogenic process using a preclinical model. METHODS AND RESULTS: Human diets, formulated to differ 2‐fold in glycemic load, were evaluated in the 1‐methyl‐nitrosourea‐in ...
DOI:
10.1002/mnfr.201500864
PubMed:
26778091
PubMed Central:
PMC4955396

6. Metabolomic analysis of the effects of edible dry beans (Phaseolus vulgaris L.) on tissue lipid metabolism and carcinogenesis in rats

Author:
McGinley, John N.,   et al.   ; Mensack, Meghan M.; Thompson, Henry J.;     Show all 3 Authors
Source:
The British journal of nutrition 2012 v.108 no.S1 pp. S155
ISSN:
1475-2662
Subject:
Phaseolus vulgaris; bioactive food compounds; biochemical pathways; biosynthesis; breast neoplasms; carcinogenesis; carcinoma; computer software; diacylglycerols; dry beans; fatty acids; genes; lipid metabolism; liquid chromatography; mammary glands; metabolites; metabolomics; nutrition risk assessment; principal component analysis; protein kinase C; rats; spectral analysis; steroid metabolism
Abstract:
... Metabolite profiling using liquid chromatography–time-of-flight MS was undertaken to identify candidate metabolic processes that account for dry bean effects on disease risk with a specific focus on the development of breast cancer. Normal mammary gland and mammary carcinomas from previously reported experiments were evaluated. Principal component analysis (PCA) of mass spectral data revealed that ...
DOI:
10.1017/S0007114512000827
PubMed:
22916811

7. In Vitro Measures Used to Predict Anticancer Activity of Apple Cultivars and Their Comparison to Outcomes From a Rat Model of Experimentally Induced Breast Cancer

Author:
McGinley, John N.,   et al.   ; Thompson, Matthew D.; Stushnoff, Cecil; Thompson, Henry J.;     Show all 4 Authors
Source:
Nutrition and cancer 2009 v.61 no.4 pp. 510-517
ISSN:
0163-5581
Subject:
breast neoplasms; cultivars; human cell lines; apples; chemical constituents of plants; histology; phenolic acids; flavonoids; carcinoma; free radical scavengers; in vitro studies; rats; antioxidant activity; apoptosis; animal disease models; anticarcinogenic activity
Abstract:
... Experiments reported herein tested the hypothesis that cultivars of apple (Malus domestica Borkh.) would demonstrate anticancer activity in vivo as predicted by in vitro measures. Freeze dried powders of Red Delicious (RD), Fuji (FJ), Golden Delicious (GD), and Granny Smith (GS) apple cultivars were evaluated. Significant differences were noted among cultivars in total phenolics (P < 0.0001), flav ...
DOI:
10.1080/01635580902825563
PubMed:
19838923

8. Chemical Composition and Mammary Cancer Inhibitory Activity of Dry Bean

Author:
McGinley, John N.,   et al.   ; Thompson, Matthew D.; Brick, Mark A.; Thompson, Henry J.;     Show all 4 Authors
Source:
Crop science 2009 v.49 no.1 pp. 179-186
ISSN:
1435-0653
Subject:
beans; food composition; breast neoplasms; anticarcinogenic activity; phenolic compounds; flavonoids; antioxidant activity; free radical scavengers; rats; animal models; disease incidence; disease severity; testa; color; nutrient content; provenance
Abstract:
... The global economic burden caused by chronic diseases such as diabetes, heart disease, and cancer is enormous. Little information exists about the role that specific crops in the diet play to reduce these diseases. To address this question, the phenolic and flavonoid contents, oxygen radical absorbance capacity (ORAC), and anticancer activity of six market classes of dry bean (Phaseolus vulgaris L ...
DOI:
10.2135/cropsci2008.04.0218

9. Functional food characteristics of potato cultivars (Solanum tuberosum L.): Phytochemical composition and inhibition of 1-methyl-1-nitrosourea induced breast cancer in rats

Author:
McGinley, John N.,   et al.   ; Thompson, Matthew D.; Thompson, Henry J.; Neil, Elizabeth S.; Rush, Denise K.; Holm, David G.; Stushnoff, Cecil;     Show all 7 Authors
Source:
Subtropical plant science 2009 v.22 no.6 pp. 571-576
ISSN:
0889-1575
Subject:
Solanum tuberosum; cultivars; chemical composition; phytochemicals; antinutritional factors; anticarcinogenic activity; health foods; nutritional intervention; freeze drying; baking; powdered foods; rats; animal models; cooked foods; breast neoplasms
Abstract:
... Effects of freeze-dried potato powder, prepared from baked potato with skin and incorporated into a purified diet, on the post-initiation phase of chemically induced breast carcinogenesis in rats, were evaluated for both dose dependence and variation in anticancer activity among cultivars. Associations among anticancer activity, select phytochemicals, and antioxidant capacity were investigated. No ...
DOI:
10.1016/j.jfca.2008.09.002

10. Mechanisms Associated with Dose-Dependent Inhibition of Rat Mammary Carcinogenesis by Dry Bean (Phaseolus vulgaris, L.)

Author:
McGinley, John N.,   et al.   ; Thompson, Matthew D.; Thompson, Henry J.; Brick, Mark A.; Jiang, Weiqin; Zhu, Zongjian; Wolfe, Pamela;     Show all 7 Authors
Source:
Journal of nutrition 2008 v.138 no.11 pp. 2091-2097
ISSN:
0022-3166
Subject:
carcinogenesis; functional foods; breast neoplasms; dose response; experimental diets; mammary neoplasms (animal); Phaseolus vulgaris; animal models; rats; risk reduction; apoptosis; dry beans
Abstract:
... The purpose of this study was to determine whether a dry bean (Phaseolus vulgaris, L.) containing diet exerts an inhibitory effect on mammary carcinogenesis in a well-characterized rodent model for breast cancer. Twenty-one-d-old female Sprague Dawley rats were given an intraperitoneal injection of 1-methyl-1-nitrosourea and 7 d after carcinogen injection were randomized to 1 of 5 groups fed a mod ...
DOI:
10.3945/jn.108.094557