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- Mellott, Tiffany J., et al. Show all 3 Authors
- Nutrients 2017 v.9 no.8
- Alzheimer disease; DNA methylation; S-adenosylmethionine; acetylcholine; adulthood; adults; animal models; betaine; brain; choline; cognition; cognitive disorders; docosahexaenoic acid; eicosapentaenoic acid; epilepsy; fetal alcohol syndrome; gene expression; histones; mechanism of action; memory; memory disorders; moieties; neuroprotective effect; neurotransmitters; patients; phosphatidylcholines; postnatal development; pregnancy; rats
- ... Choline is an essential nutrient for humans. It is a precursor of membrane phospholipids (e.g., phosphatidylcholine (PC)), the neurotransmitter acetylcholine, and via betaine, the methyl group donor S-adenosylmethionine. High choline intake during gestation and early postnatal development in rat and mouse models improves cognitive function in adulthood, prevents age-related memory decline, and pro ...
- Mellott, Tiffany J., et al. Show all 7 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.48 pp. 19567-19572
- Alzheimer disease; Hippocampus hippocampus; amyloid; amyloidosis; animal models; bone morphogenetic proteins; cerebral cortex; choline acetyltransferase; genetically modified organisms; genotype; green fluorescent protein; hippocampus; insulin-like growth factor I; memory; mice; nerve growth factor; neurons; patients; phenotype; receptor protein-tyrosine kinase; receptors
- ... Bone morphogenetic protein 9 (BMP9) promotes the acquisition of the cholinergic phenotype in basal forebrain cholinergic neurons (BFCN) during development and protects these neurons from cholinergic dedifferentiation following axotomy when administered in vivo. A decline in BFCN function occurs in patients with Alzheimer’s disease (AD) and contributes to the AD-associated memory deficits. We infus ...
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