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- Author:
- Pan Wang; Peiyang Ding; Qiang Wei; Hongliang Liu; Yunchao Liu; Qingmei Li; Yunrui Xing; Ge Li; Enmin Zhou; Gaiping Zhang
- Source:
- International journal of biological macromolecules 2022 v.195 pp. 609-619
- ISSN:
- 0141-8130
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; Coronavirus infections; alanine; epitopes; humans; mortality; mutagenesis; nucleic acid hybridization; peptides; sequence alignment; Show all 10 Subjects
- Abstract:
- ... Middle East respiratory syndrome coronavirus (MERS-CoV) is a coronavirus which can cause severe human respiratory diseases with a fatality rate of almost 36%.In this study, we report the generation, characterization and epitope mapping of several monoclonal antibodies against the spike receptor-binding domain (RBD) of MERS-CoV. Two monoclonal antibodies (4C7 and 6E8) that can react with linearized ...
- DOI:
- 10.1016/j.ijbiomac.2021.11.192
- https://doi.org/10.1016/j.ijbiomac.2021.11.192
- Author:
- Bo-Kyoung Jung; YongHee An; Jung-Eun Park; Kyung-Soo Chang; Hyun Jang
- Source:
- Journal of virological methods 2022 v.299 pp. 114347
- ISSN:
- 0166-0934
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; Coronavirus infections; Cricetulus griseus; humans; humoral immunity; immunogenicity; immunoglobulin G; recombinant vaccines; secretion; therapeutics; virulent strains; Show all 11 Subjects
- Abstract:
- ... The Middle East respiratory syndrome coronavirus (MERS-CoV), belonging to the family Coronaviridae and genus Betacoronavirus, has been recognized as a highly pathogenic virus. Due to the lack of therapeutic or preventive agents against MERS-CoV, developing an effective vaccine is essential for preventing a viral outbreak. To address this, we developed a recombinant S1 subunit of MERS-CoV spike pro ...
- DOI:
- 10.1016/j.jviromet.2021.114347
- https://doi.org/10.1016/j.jviromet.2021.114347
- Author:
- Avinash Premraj; Abi George Aleyas; Binita Nautiyal; Thaha Jamal Rasool
- Source:
- Developmental and comparative immunology 2022 v.133 pp. 104443
- ISSN:
- 0145-305X
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; COVID-19 infection; Camelpox virus; Camelus dromedarius; RNA; antiviral agents; camels; genes; immune response; kidneys; pandemic; pathogens; Show all 12 Subjects
- Abstract:
- ... The COVID-19 pandemic is a wake-up call on the zoonotic viral spillover events and the need to be prepared for future outbreaks. Zoonotic RNA viruses like the Middle East respiratory syndrome coronavirus (MERS-CoV) are potential pathogens that could trigger the next pandemic. Dromedary camels are the only known animal source of MERS-CoV zoonotic infections, but little is known about the molecular ...
- DOI:
- 10.1016/j.dci.2022.104443
- https://doi.org/10.1016/j.dci.2022.104443
- Author:
- Mahmoud Kandeel
- Source:
- One health 2022 v.15 pp. 100436
- ISSN:
- 2352-7714
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; Camelus dromedarius; Coronavirus infections; blood serum; camels; confidence interval; meta-analysis; seroprevalence; viruses; zoonoses; Middle East; Sub-Saharan Africa; Show all 12 Subjects
- Abstract:
- ... The zoonotic Middle East respiratory syndrome (MERS) is caused by an emerging beta-coronavirus (CoV). The majority of MERS studies have included scattered data from sub-Saharan Africa and the Middle East, and these data have not been analyzed collectively. In this work, a meta-analysis of these studies was conducted to coalesce these results, determine the prevalence and seroprevalence of MERS-CoV ...
- DOI:
- 10.1016/j.onehlt.2022.100436
- https://doi.org/10.1016/j.onehlt.2022.100436
- Author:
- Rudragouda Channappanavar; Muneeswaran Selvaraj; Sunil More; Stanley Perlman
- Source:
- Veterinary pathology 2022 v.59 no.4 pp. 627-638
- ISSN:
- 1544-2217
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; CD4-positive T-lymphocytes; COVID-19 infection; animal pathology; disease severity; humans; inflammation; lungs; macrophages; mice; morbidity; mortality; neutrophils; pathogenesis; pneumonia; Show all 15 Subjects
- Abstract:
- ... Emerging and re-emerging human coronaviruses (hCoVs) cause severe respiratory illness in humans, but the basis for lethal pneumonia in these diseases is not well understood. Alveolar macrophages (AMs) are key orchestrators of host antiviral defense and tissue tolerance during a variety of respiratory infections, and AM dysfunction is associated with severe COVID-19. In this study, using a mouse mo ...
- DOI:
- 10.1177/03009858221095270
- https://doi.org/10.1177/03009858221095270
- Author:
- Jung-ah Choi; Jae-Ouk Kim
- Source:
- journal of microbiology 2022 v.60 no.3 pp. 238-246
- ISSN:
- 1225-8873
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; COVID-19 infection; DNA; World Health Organization; genes; glycoproteins; health services; immunogenicity; mortality; pathogens; protein subunits; respiratory tract diseases; vaccine development; viruses; Show all 14 Subjects
- Abstract:
- ... Middle East Respiratory Syndrome coronavirus (MERS-CoV), a contagious zoonotic virus, causes severe respiratory infection with a case fatality rate of approximately 35% in humans. Intermittent sporadic cases in communities and healthcare facility outbreaks have continued to occur since its first identification in 2012. The World Health Organization has declared MERS-CoV a priority pathogen for wor ...
- DOI:
- 10.1007/s12275-022-1547-8
- https://doi.org/10.1007/s12275-022-1547-8
- Author:
- Rongfeng Tang; Longjun Guo; Qianjin Fan; Liaoyuan Zhang; Yiming Wang; Xin Zhang; Da Shi; Yang Wu; Hongyan Shi; Jianbo Liu; Jianfei Chen; Li Feng
- Source:
- Veterinary microbiology 2022 v.264 pp. 109299
- ISSN:
- 0378-1135
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; Coronavirus infections; Porcine deltacoronaviruses; Porcine epidemic diarrhea virus; Severe acute respiratory syndrome coronavirus; adsorption; antiviral properties; cell culture; diarrhea; lectins; oligosaccharides; viruses; Show all 12 Subjects
- Abstract:
- ... Porcine deltacoronavirus (PDCoV) is an emerging porcine enteric coronavirus that causes severe diarrhea in piglets and results in serious economic losses. There are no effective vaccines and antiviral drugs to prevent and treat PDCoV infection currently. Griffithsin (GRFT) is a lectin with potent antiviral activity against enveloped viruses because of its ability to specifically bind N-linked high ...
- DOI:
- 10.1016/j.vetmic.2021.109299
- https://doi.org/10.1016/j.vetmic.2021.109299
- Author:
- An‐Ran Zhang; Xin‐Lou Li; Tao Wang; Kun Liu; Ming‐Jin Liu; Wen‐Hui Zhang; Guo‐Ping Zhao; Jin‐Jin Chen; Xiao‐Ai Zhang; Dong Miao; Wei Ma; Li‐Qun Fang; Yang Yang; Wei Liu
- Source:
- Transboundary and emerging diseases 2022 v.69 no.5 pp. e2122
- ISSN:
- 1865-1674
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; Coronavirus infections; Severe acute respiratory syndrome coronavirus 2; camels; enzootic diseases; models; monitoring; pandemic; population density; temperature; Middle East; Northern Africa; South Asia; Show all 13 Subjects
- Abstract:
- ... The ongoing enzootic circulation of the Middle East respiratory syndrome coronavirus (MERS‐CoV) in the Middle East and North Africa is increasingly raising the concern about the possibility of its recombination with other human‐adapted coronaviruses, particularly the pandemic SARS‐CoV‐2. We aim to provide an updated picture about ecological niches of MERS‐CoV and associated socio‐environmental dri ...
- DOI:
- 10.1111/tbed.14548
- https://doi.org/10.1111/tbed.14548
- Author:
- Nigeer Te; Malgorzata Ciurkiewicz; Judith M. A. van den Brand; Jordi Rodon; Ann-Kathrin Haverkamp; Júlia Vergara-Alert; Albert Bensaid; Bart L. Haagmans; Wolfgang Baumgartner; Joaquim Segalés
- Source:
- Veterinary pathology 2022 v.59 no.4 pp. 546-555
- ISSN:
- 1544-2217
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; Camelus dromedarius; Coronavirus infections; World Health Organization; animal pathology; epidemiology; epithelium; hyperplasia; macrophages; mortality; neutrophils; pathogenesis; respiratory system; respiratory tract diseases; vaccination; vaccines; viral antigens; viruses; zoonoses; Show all 19 Subjects
- Abstract:
- ... Middle East respiratory syndrome coronavirus (MERS-CoV) is the cause of a severe respiratory disease with a high case fatality rate in humans. Since its emergence in mid-2012, 2578 laboratory-confirmed cases in 27 countries have been reported by the World Health Organization, leading to 888 known deaths due to the disease and related complications. Dromedary camels are considered the major reservo ...
- DOI:
- 10.1177/03009858211069120
- https://doi.org/10.1177/03009858211069120
- Author:
- Sook‐Young Lee; Chul‐Un Chung; Jun Soo Park; Yoon Ji Kim; Young‐Sik Kim; Eun‐Jee Na; YongKwan Kim; Jae‐Ku Oem
- Source:
- Transboundary and emerging diseases 2022 v.69 no.4 pp. e463
- ISSN:
- 1865-1674
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; Ebolavirus; Hendra henipavirus; Lyssavirus; Marburg marburgvirus; Nipah henipavirus; Rhinolophidae; autumn; epidemiological studies; feces; genes; genetic analysis; genetic variation; glycoproteins; hosts; humans; monitoring; mutants; phylogeny; spring; urine; South Korea; Show all 22 Subjects
- Abstract:
- ... Bats have been identified as a natural reservoir of several potentially zoonotic viruses, including Lyssavirus, Ebola virus, Marburg virus, Hendra virus, Nipah virus, as well as severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus (CoV). Here, we performed a molecular epidemiological investigation of South Korean bat viruses. Genetic comparative analysis was performed ...
- DOI:
- 10.1111/tbed.14324
- https://doi.org/10.1111/tbed.14324
- Author:
- Chad S. Clancy; Carl Shaia; Vincent Munster; Emmie de Wit; David Hawman; Atsushi Okumura; Heinz Feldmann; Greg Saturday; Dana Scott
- Source:
- Veterinary pathology 2022 v.59 no.4 pp. 673-680
- ISSN:
- 1544-2217
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; COVID-19 infection; Cercopithecus aethiops; Macaca mulatta; Saimiri; Severe acute respiratory syndrome coronavirus 2; animal pathology; edema; fibrin; histopathology; humans; hyperplasia; immunohistochemistry; pandemic; pneumocytes; pneumonia; squirrels; viral antigens; Show all 18 Subjects
- Abstract:
- ... Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an emergent, amphixenotic infection that resulted in a pandemic declaration in March 2020. A rapid search for appropriate animal models of this newly emergent viral respiratory disease focused initially on traditional nonhuman primate research species. Nonhuman primate models have pr ...
- DOI:
- 10.1177/03009858211067468
- https://doi.org/10.1177/03009858211067468
- Author:
- Gen Li; Shao‐Lun Zhai; Xia Zhou; Tian‐bao Chen; Jia‐wei Niu; Yong‐sheng Xie; Guang‐bin Si; Feng Cong; Rui‐ai Chen; Dong‐sheng He
- Source:
- Transboundary and emerging diseases 2022 v.69 no.5 pp. e1670
- ISSN:
- 1865-1674
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; Coronavirus infections; Porcine deltacoronaviruses; Severe acute respiratory syndrome coronavirus; Severe acute respiratory syndrome coronavirus 2; amino acids; biosecurity; disease transmission; genetic analysis; genetic variation; membrane fusion; monitoring; mutation; phylogeny; phylogeography; swine; zoonoses; Asia; Show all 18 Subjects
- Abstract:
- ... From 2003 onwards, three pandemics have been caused by coronaviruses: severe acute respiratory syndrome coronavirus (SARS‐CoV); middle east respiratory syndrome coronavirus (MERS‐CoV); and, most recently, SARS‐CoV‐2. Notably, all three were transmitted from animals to humans. This would suggest that animals are potential sources of epidemics for humans. The emerging porcine delta‐coronavirus was r ...
- DOI:
- 10.1111/tbed.14503
- https://doi.org/10.1111/tbed.14503
- Author:
- Jung-Eun Park; Ji-Hee Kim; Jae-Yeon Park; Sung-Hoon Jun; Hyun-Jin Shin
- Source:
- Virology journal 2022 v.19 no.1 pp. 112
- ISSN:
- 1743-422X
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; Coronavirus infections; Murine hepatitis virus; Western blotting; antiviral agents; cryo-electron microscopy; glycosylation; humans; immunization; immunogenicity; lungs; mice; mortality; neutralization tests; nucleocapsid; public health; respiratory tract diseases; virology; virus-like particle vaccines; viruses; Show all 20 Subjects
- Abstract:
- ... BACKGROUND: Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease in humans, with a case fatality rate of approximately 35%, thus posing a considerable threat to public health. The lack of approved vaccines or antivirals currently constitutes a barrier in controlling disease outbreaks and spread. METHODS: In this study, using a mammalian expression system, which ...
- DOI:
- 10.1186/s12985-022-01844-9
- https://doi.org/10.1186/s12985-022-01844-9
- Author:
- Sen Zeng; Yuwan Li; Wenhui Zhu; Zipeng Luo; Keke Wu; Xiaowen Li; Yiqi Fang; Yuwei Qin; Wenxian Chen; Zhaoyao Li; Linke Zou; Xiaodi Liu; Lin Yi; Shuangqi Fan
- Source:
- Microorganisms 2022 v.10 no.7 pp. -
- ISSN:
- 2076-2607
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; Betacoronavirus 1; Infectious bronchitis virus; Murine hepatitis virus; Porcine epidemic diarrhea virus; Severe acute respiratory syndrome coronavirus 2; antiviral agents; chickens; diarrhea; drug therapy; gastroenteritis; humans; immunization; morbidity; mortality; public health; swine; vaccines; viruses; Show all 19 Subjects
- Abstract:
- ... Coronaviruses, mainly including severe acute respiratory syndrome virus, severe acute respiratory syndrome coronavirus 2, Middle East respiratory syndrome virus, human coronavirus OC43, chicken infectious bronchitis virus, porcine infectious gastroenteritis virus, porcine epidemic diarrhea virus, and murine hepatitis virus, can cause severe diseases in humans and livestock. The severe acute respir ...
- DOI:
- 10.3390/microorganisms10071294
- https://doi.org/10.3390/microorganisms10071294
- Author:
- Isaac Ngere; Elizabeth A. Hunsperger; Suxiang Tong; Julius Oyugi; Walter Jaoko; Jennifer L. Harcourt; Natalie J. Thornburg; Harry Oyas; Mathew Muturi; Eric M. Osoro; John Gachohi; Cynthia Ombok; Jeanette Dawa; Ying Tao; Jing Zhang; Lydia Mwasi; Caroline Ochieng; Athman Mwatondo; Boku Bodha; Daniel Langat; Amy Herman-Roloff; M. Kariuki Njenga; Marc-Alain Widdowson; Peninah M. Munyua
- Source:
- Viruses 2022 v.14 no.8 pp. -
- ISSN:
- 1999-4915
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; Coronavirus infections; RNA; camels; genome; human diseases; humans; nose; viruses; Kenya; Show all 10 Subjects
- Abstract:
- ... The majority of Kenya’s > 3 million camels have antibodies against Middle East respiratory syndrome coronavirus (MERS-CoV), although human infection in Africa is rare. We enrolled 243 camels aged 0–24 months from 33 homesteads in Northern Kenya and followed them between April 2018 to March 2020. We collected and tested camel nasal swabs for MERS-CoV RNA by RT-PCR followed by virus isolation and wh ...
- DOI:
- 10.3390/v14081743
- https://doi.org/10.3390/v14081743
16. Hydrophobic Alpha-Helical Short Peptides in Overlapping Reading Frames of the Coronavirus Genome
- Author:
- Takashi Okura; Kazuya Shirato; Masatoshi Kakizaki; Satoko Sugimoto; Shutoku Matsuyama; Tomohisa Tanaka; Yohei Kume; Mina Chishiki; Takashi Ono; Kohji Moriishi; Masashi Sonoyama; Mitsuaki Hosoya; Koichi Hashimoto; Katsumi Maenaka; Makoto Takeda
- Source:
- Pathogens 2022 v.11 no.8 pp. -
- ISSN:
- 2076-0817
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; Coronavirus infections; RNA; Severe acute respiratory syndrome coronavirus 2; genes; hydrophobicity; membrane fusion; peptides; viral genome; Show all 9 Subjects
- Abstract:
- ... In this study, we show that the coronavirus (CoV) genome may encode many functional hydrophobic alpha-helical peptides (HAHPs) in overlapping reading frames of major coronaviral proteins throughout the entire viral genome. These HAHPs can theoretically be expressed from non-canonical sub-genomic (sg)RNAs that are synthesized in substantial amounts in infected cells. We selected and analyzed five a ...
- DOI:
- 10.3390/pathogens11080877
- https://doi.org/10.3390/pathogens11080877
- Author:
- Tariq A. Madani; El-Tayb M.E. Abuelzein; Hashem S. Hussien; Mohammad A. Bashri; Ahmed M. Hassan; Esam I. Azhar
- Source:
- Vector borne and zoonotic diseases 2021 v.21 no.12 pp. 994-1002
- ISSN:
- 1557-7759
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; Coronavirus infections; RNA; anorexia; body temperature; epidemiology; females; herds; neonates; nose; parturition; rhinitis; standard deviation; viruses; Show all 14 Subjects
- Abstract:
- ... Background: Camel-to-human transmission of the Middle East Respiratory Syndrome coronavirus (MERS-CoV) was confirmed as a cause of primary infection in humans. There is a dearth of information regarding the behavior of the virus in camels and the mode of spread among them under natural conditions. The aim of this study was to monitor exposure of camels to the MERS-CoV under field conditions. Metho ...
- DOI:
- 10.1089/vbz.2021.0020
- https://doi.org/10.1089/vbz.2021.0020
18. The roles of signaling pathways in SARS-CoV-2 infection; lessons learned from SARS-CoV and MERS-CoV
- Author:
- Nima Hemmat; Zahra Asadzadeh; Noora Karim Ahangar; Hajar Alemohammad; Basira Najafzadeh; Afshin Derakhshani; Amir Baghbanzadeh; Hossein Bannazadeh Baghi; Darya Javadrashid; Souzan Najafi; Meriadeg Ar Gouilh; Behzad Baradaran
- Source:
- Archives of virology 2021 v.166 no.3 pp. 675-696
- ISSN:
- 0304-8608
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; human population; humans; inflammation; pathogenesis; therapeutics; virology; Show all 9 Subjects
- Abstract:
- ... The number of descriptions of emerging viruses has grown at an unprecedented rate since the beginning of the 21ˢᵗ century. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), is the third highly pathogenic coronavirus that has introduced itself into the human population in the current era, after SARS-CoV and Middle East respiratory syndro ...
- DOI:
- 10.1007/s00705-021-04958-7
- https://doi.org/10.1007/s00705-021-04958-7
- Author:
- Duncan R. Smith
- Source:
- Journal of virological methods 2021 v.289 pp. 114034
- ISSN:
- 0166-0934
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; Severe acute respiratory syndrome coronavirus; Severe acute respiratory syndrome coronavirus 2; common cold; humans; livestock; Thailand; Show all 7 Subjects
- Abstract:
- ... As with many countries around the world, Thailand is currently experiencing restrictions to daily life as a consequence of the worldwide transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is the third respiratory syndrome coronavirus to be introduced into Thailand, following previous importation of cases of the severe acute respiratory syndrome coronavirus ...
- DOI:
- 10.1016/j.jviromet.2020.114034
- https://doi.org/10.1016/j.jviromet.2020.114034
- Author:
- Nigeer Te; Jordi Rodon; Rhea Creve; Mónica Pérez; Joaquim Segalés; Júlia Vergara-Alert; Albert Bensaid
- Source:
- BMC veterinary research 2022 v.53 no.1 pp. 67
- ISSN:
- 1297-9716
- Subject:
- Middle East respiratory syndrome coronavirus, etc ; Camelidae; Coronavirus infections; alpacas; ex vivo studies; liquid-air interface; models; nasal mucosa; public health; veterinary medicine; Show all 10 Subjects
- Abstract:
- ... Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to public health. Here, we established an ex vivo alpaca tracheal explant (ATE) model using an air-liquid interface culture system to gain insights into MERS-CoV infection in the camelid lower respiratory tract. ATE can be infected by MERS-CoV, being 10³ TCID₅₀/mL the minimum viral dosage required to establish a product ...
- DOI:
- 10.1186/s13567-022-01084-3
- https://doi.org/10.1186/s13567-022-01084-3